Entity Details

Primary name MLH3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UHC1
EntryNameMLH3_HUMAN
FullNameDNA mismatch repair protein Mlh3
TaxID9606
Evidenceevidence at protein level
Length1453
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesMLH3

GO terms

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GOName
GO:0000795 synaptonemal complex
GO:0001673 male germ cell nucleus
GO:0003682 chromatin binding
GO:0003696 satellite DNA binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005712 chiasma
GO:0006298 mismatch repair
GO:0007130 synaptonemal complex assembly
GO:0007131 reciprocal meiotic recombination
GO:0007140 male meiotic nuclear division
GO:0007144 female meiosis I
GO:0008104 protein localization
GO:0016887 ATP hydrolysis activity
GO:0019237 centromeric DNA binding
GO:0030983 mismatched DNA binding
GO:0032300 mismatch repair complex

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR013507 DNA mismatch repair protein, S5 domain 2-likeDomainDomain
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroupFamilyHomologous superfamily
IPR014762 DNA mismatch repair, conserved siteSiteConserved site
IPR014790 MutL, C-terminal, dimerisationDomainDomain
IPR020568 Ribosomal protein S5 domain 2-type foldFamilyHomologous superfamily
IPR028830 DNA mismatch repair protein Mlh3FamilyFamily
IPR036890 Histidine kinase/HSP90-like ATPase superfamilyFamilyHomologous superfamily
IPR037198 MutL, C-terminal domain superfamilyFamilyHomologous superfamily
IPR038973 DNA mismatch repair protein MutL/Mlh/PmsFamilyFamily
IPR042120 MutL, C-terminal domain, dimerisation subdomainFamilyHomologous superfamily
IPR042121 MutL, C-terminal domain, regulatory subdomainFamilyHomologous superfamily

Diseases

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Interactions

51 interactions

InteractorPartnerSourcesPublicationsLink
MLH3_HUMANAKT1_HUMANBioGRID, MINT24412244 details
MLH3_HUMANALDOB_HUMANBioGRID, MINT24412244 details
MLH3_HUMANAN32B_HUMANBioGRID, MINT24412244 details
MLH3_HUMANBAAT_HUMANBioGRID, MINT24412244 details
MLH3_HUMANAMPO_HUMANBioGRID, MINT24412244 details
MLH3_HUMANMSD3_HUMANBioGRID, MINT24412244 details
MLH3_HUMANTSTD2_HUMANBioGRID, MINT24412244 details
MLH3_HUMANCC14B_HUMANBioGRID, MINT24412244 details
MLH3_HUMANCDK8_HUMANBioGRID, MINT24412244 details
MLH3_HUMANCATL2_HUMANBioGRID, MINT24412244 details
MLH3_HUMANCYLC2_HUMANBioGRID, MINT24412244 details
MLH3_HUMANDVL1_HUMANBioGRID, MINT24412244 details
MLH3_HUMANFANCC_HUMANBioGRID, MINT24412244 details
MLH3_HUMANF16P1_HUMANBioGRID, MINT24412244 details
MLH3_HUMANF16P2_HUMANBioGRID, MINT24412244 details
MLH3_HUMANFRAT2_HUMANBioGRID, MINT24412244 details
MLH3_HUMANGLT12_HUMANBioGRID, MINT24412244 details
MLH3_HUMANRASH_HUMANBioGRID, MINT24412244 details
MLH3_HUMANHEMGN_HUMANBioGRID, MINT24412244 details
MLH3_HUMANDHB3_HUMANBioGRID, MINT24412244 details
MLH3_HUMANIBP3_HUMANBioGRID, MINT24412244 details
MLH3_HUMANCC180_HUMANBioGRID, MINT24412244 details
MLH3_HUMANLEF1_HUMANBioGRID, MINT24412244 details
MLH3_HUMANMP2K1_HUMANBioGRID, MINT24412244 details
MLH3_HUMANSIAS_HUMANBioGRID, MINT24412244 details
MLH3_HUMANPP2AB_HUMANBioGRID, MINT24412244 details
MLH3_HUMANCANB2_HUMANBioGRID, MINT24412244 details
MLH3_HUMANRASA1_HUMANBioGRID, MINT24412244 details
MLH3_HUMANSC61B_HUMANBioGRID, MINT24412244 details
MLH3_HUMANSFRP2_HUMANBioGRID, MINT24412244 details
MLH3_HUMANSMAD1_HUMANBioGRID, MINT24412244 details
MLH3_HUMANSTX17_HUMANBioGRID, MINT24412244 details
MLH3_HUMANTBD2A_HUMANBioGRID, MINT24412244 details
MLH3_HUMANTDRD7_HUMANBioGRID, MINT24412244 details
MLH3_HUMANTEFF1_HUMANBioGRID, MINT24412244 details
MLH3_HUMANTGFB1_HUMANBioGRID, MINT24412244 details
MLH3_HUMANTMOD1_HUMANBioGRID, MINT24412244 details
MLH3_HUMANXPA_HUMANBioGRID, MINT24412244 details
MLH3_HUMANZN510_HUMANBioGRID, MINT24412244 details
MLH3_HUMANZDH17_HUMANBioGRID, IntAct24705354 details
MLH3_HUMANTRI63_HUMANBioGRID, IntAct31391242 details
MLH3_HUMANTRI55_HUMANBioGRID, IntAct31391242 details
MLH3_HUMANMLH1_HUMANBioGRID, HPRD, IntAct10615123 11292842 24443562 27229929 32814343 details
MLH3_HUMANSPRE1_HUMANIntAct32814053 details
MLH3_HUMANMSH4_HUMANBioGRID, HPRD12095912 32814904 details
MLH3_HUMANANDR_HUMANBioGRID19762545 details
MLH3_HUMANMSH5_HUMANBioGRID32814904 details
MLH3_HUMANEXO1_HUMANBioGRID32814904 details
MLH3_HUMANPCNA_HUMANBioGRID32814904 details
MLH3_HUMANFAN1_HUMANBioGRID20603073 details
MLH3_HUMANMLH3_HUMANHPRD12095912 details