Entity Details

Primary name MYO15_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UKN7
EntryNameMYO15_HUMAN
FullNameUnconventional myosin-XV
TaxID9606
Evidenceevidence at protein level
Length3530
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesMYO15A

GO terms

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GOName
GO:0000146 microfilament motor activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0007015 actin filament organization
GO:0007605 sensory perception of sound
GO:0015629 actin cytoskeleton
GO:0016459 myosin complex
GO:0030050 vesicle transport along actin filament
GO:0031982 vesicle
GO:0032420 stereocilium
GO:0051015 actin filament binding
GO:0070062 extracellular exosome
GO:0098858 actin-based cell projection

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR000048 IQ motif, EF-hand binding siteSiteBinding site
IPR000299 FERM domainDomainDomain
IPR000857 MyTH4 domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR001609 Myosin head, motor domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR019748 FERM central domainDomainDomain
IPR019749 Band 4.1 domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR035487 Unconventional myosin-XVFamilyFamily
IPR035963 FERM superfamily, second domainFamilyHomologous superfamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036057 Class XV myosin, motor domainDomainDomain
IPR036961 Kinesin motor domain superfamilyFamilyHomologous superfamily
IPR038185 MyTH4 domain superfamilyFamilyHomologous superfamily
IPR041795 Myosin-XV, FERM domain C-lobeDomainDomain

Diseases

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Disease IDSourceNameDescription
600316 OMIMDeafness, autosomal recessive, 3 (DFNB3)A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. The disease is caused by variants affecting the gene represented in this entry.

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
MYO15_HUMANEPS8_HUMANBioGRID, HPRD, IntAct16169070 details
MYO15_HUMANUBP13_HUMANBioGRID, HPRD, IntAct16169070 details
MYO15_HUMANTNFL6_HUMANBioGRID, IntAct19807924 details
MYO15_HUMANWHRN_HUMANHPRD15590698 details