Entity Details

Primary name P4HA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP13674
EntryNameP4HA1_HUMAN
FullNameProlyl 4-hydroxylase subunit alpha-1
TaxID9606
Evidenceevidence at protein level
Length534
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesP4HA1

GO terms

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GOName
GO:0004656 procollagen-proline 4-dioxygenase activity
GO:0005506 iron ion binding
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0016020 membrane
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0030199 collagen fibril organization
GO:0031418 L-ascorbic acid binding
GO:0042802 identical protein binding
GO:0043231 intracellular membrane-bounded organelle

Subcellular Location

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Subcellular Location
Endoplasmic reticulum lumen

Domains

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DomainNameCategoryType
IPR005123 Oxoglutarate/iron-dependent dioxygenaseDomainDomain
IPR006620 Prolyl 4-hydroxylase, alpha subunitDomainDomain
IPR011990 Tetratricopeptide-like helical domain superfamilyFamilyHomologous superfamily
IPR013547 Prolyl 4-hydroxylase alpha-subunit, N-terminalDomainDomain
IPR019734 Tetratricopeptide repeatRepeatRepeat

Diseases

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Drugs

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DrugNameSourceType
DB00126 Ascorbic acidDrugbanksmall molecule
DB00139 Succinic acidDrugbanksmall molecule
DB00172 ProlineDrugbanksmall molecule
DB01275 HydralazineDrugbanksmall molecule