Entity Details

Primary name 3HIDH_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP31937
EntryName3HIDH_HUMAN
FullName3-hydroxyisobutyrate dehydrogenase, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length336
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesHIBADH

GO terms

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GOName
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0006574 valine catabolic process
GO:0008442 3-hydroxyisobutyrate dehydrogenase activity
GO:0009083 branched-chain amino acid catabolic process
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0050661 NADP binding
GO:0051287 NAD binding

Subcellular Location

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Subcellular Location
Mitochondrion

Domains

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DomainNameCategoryType
IPR002204 3-hydroxyisobutyrate dehydrogenase-related, conserved siteSiteConserved site
IPR006115 6-phosphogluconate dehydrogenase, NADP-bindingDomainDomain
IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamilyFamilyHomologous superfamily
IPR011548 3-hydroxyisobutyrate dehydrogenaseFamilyFamily
IPR013328 6-phosphogluconate dehydrogenase, domain 2FamilyHomologous superfamily
IPR015815 3-hydroxyisobutyrate dehydrogenase-relatedFamilyFamily
IPR029154 3-hydroxyisobutyrate dehydrogenase, NAD-binding domainDomainDomain
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule

Interactions

40 interactions

InteractorPartnerSourcesPublicationsLink
3HIDH_HUMANEFNA5_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANTM14B_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANTM86B_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANC2C2L_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANTM6S2_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANSC22B_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANAMELY_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANPAEP_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANATRAP_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANCDS2_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANCNIH2_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANERMP1_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANCLC2A_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANAQP3_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANPPLA_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANAIG1_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANGOSR2_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANSCRB2_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANASGR1_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANZFPL1_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANCKLF7_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANMAL_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANRTP2_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANTFR1_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANSNORC_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANVAMP5_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANCOMT_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANNDUBB_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANPRAF2_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANSFT2B_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANTM222_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANUBIA1_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANPTC1_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANADA33_HUMANBioGRID32296183 details
3HIDH_HUMANVAMP2_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANTRI63_HUMANBioGRID15967462 details
3HIDH_HUMANBRCA1_HUMANBioGRID22990118 details
3HIDH_HUMANTMM60_HUMANBioGRID, IntAct32296183 details
3HIDH_HUMANPPGB_HUMANBioGRID32296183 details
3HIDH_HUMAN3HIDH_HUMANBioGRID, HPRD3335502 details