Entity Details

Primary name VATA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP38606
EntryNameVATA_HUMAN
FullNameV-type proton ATPase catalytic subunit A
TaxID9606
Evidenceevidence at protein level
Length617
SequenceStatuscomplete
DateCreated1994-10-01
DateModified2021-06-02

Ontological Relatives

GenesATP6V1A

GO terms

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GOName
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0006879 cellular iron ion homeostasis
GO:0008286 insulin receptor signaling pathway
GO:0016241 regulation of macroautophagy
GO:0016324 apical plasma membrane
GO:0016469 proton-transporting two-sector ATPase complex
GO:0016887 ATP hydrolysis activity
GO:0033180 proton-transporting V-type ATPase, V1 domain
GO:0033572 transferrin transport
GO:0034198 cellular response to amino acid starvation
GO:0034220 ion transmembrane transport
GO:0036295 cellular response to increased oxygen levels
GO:0043231 intracellular membrane-bounded organelle
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
GO:0046961 proton-transporting ATPase activity, rotational mechanism
GO:0070062 extracellular exosome
GO:0090383 phagosome acidification
GO:1902600 proton transmembrane transport

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic vesicle

Domains

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DomainNameCategoryType
IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domainDomainDomain
IPR004100 ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domainDomainDomain
IPR005725 ATPase, V1 complex, subunit AFamilyFamily
IPR020003 ATPase, alpha/beta subunit, nucleotide-binding domain, active siteSiteActive site
IPR022878 V-type ATP synthase catalytic alpha chainFamilyFamily
IPR023366 ATP synthase subunit alpha, N-terminal domain-like superfamilyFamilyHomologous superfamily
IPR024034 ATPase, F1/V1 complex, beta/alpha subunit, C-terminalFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR031686 ATPsynthase alpha/beta subunit, N-terminal extensionDomainDomain
IPR036121 ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00630 Alendronic acidDrugbanksmall molecule
DB01077 Etidronic acidDrugbanksmall molecule
DB01133 Tiludronic acidDrugbanksmall molecule
DB06733 Bafilomycin A1Drugbanksmall molecule
DB06734 Bafilomycin B1Drugbanksmall molecule