Entity Details

Primary name MK10_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP53779
EntryNameMK10_HUMAN
FullNameMitogen-activated protein kinase 10
TaxID9606
Evidenceevidence at protein level
Length464
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesMAPK10

GO terms

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GOName
GO:0004674 protein serine/threonine kinase activity
GO:0004705 JUN kinase activity
GO:0004707 MAP kinase activity
GO:0004708 MAP kinase kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007254 JNK cascade
GO:0009416 response to light stimulus
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042752 regulation of circadian rhythm
GO:0048511 rhythmic process
GO:0051090 regulation of DNA-binding transcription factor activity
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR003527 Mitogen-activated protein (MAP) kinase, conserved siteSiteConserved site
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR008351 Mitogen-activated protein (MAP) kinase, JNKFamilyFamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01017 MinocyclineDrugbanksmall molecule
DB01782 PyrazolanthroneDrugbanksmall molecule
DB02388 Cyclohexyl-{4-[5-(3,4-Dichlorophenyl)-2-Piperidin-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}AmineDrugbanksmall molecule
DB03084 Cyclopropyl-{4-[5-(3,4-Dichlorophenyl)-2-[(1-Methyl)-Piperidin]-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}AmineDrugbanksmall molecule
DB03623 9-(4-Hydroxyphenyl)-2,7-PhenanthrolineDrugbanksmall molecule
DB04395 Phosphoaminophosphonic Acid-Adenylate EsterDrugbanksmall molecule
DB06933 N-(tert-butyl)-4-[5-(pyridin-2-ylamino)quinolin-3-yl]benzenesulfonamideDrugbanksmall molecule
DB07010 N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDEDrugbanksmall molecule
DB07217 N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamideDrugbanksmall molecule
DB08005 4-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-N-ethylpiperidine-1-carboxamideDrugbanksmall molecule
DB08010 (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-[(E)-2-phenylethenyl]-1H-indole-2,3-dione 3-oximeDrugbanksmall molecule
DB08011 (3E)-5-fluoro-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-1H-indole-2,3-dione 3-oximeDrugbanksmall molecule
DB08015 (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-phenyl-1H-indole-2,3-dione 3-oximeDrugbanksmall molecule
DB08021 5-bromo-N-(3-chloro-2-(4-(prop-2-ynyl)piperazin-1-yl)phenyl)furan-2-carboxamideDrugbanksmall molecule
DB08023 N-cyclohexyl-4-imidazo[1,2-a]pyridin-3-yl-N-methylpyrimidin-2-amineDrugbanksmall molecule
DB08025 N-{2'-[(4-FLUOROPHENYL)AMINO]-4,4'-BIPYRIDIN-2-YL}-4-METHOXYCYCLOHEXANECARBOXAMIDEDrugbanksmall molecule
DB08026 2-{4-[(4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]piperidin-1-yl}-N-methylacetamideDrugbanksmall molecule
DB08555 1-(3-bromophenyl)-7-chloro-6-methoxy-3,4-dihydroisoquinolineDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB15624 HalicinDrugbanksmall molecule

Interactions

46 interactions

InteractorPartnerSourcesPublicationsLink
MK10_HUMANU119A_HUMANBioGRID, HPRD, IntAct16169070 details
MK10_HUMANTF3C1_HUMANBioGRID, HPRD, IntAct16169070 details
MK10_HUMANPLIN2_HUMANBioGRID, IntAct18624398 details
MK10_HUMANJUN_HUMANBioGRID, DIP, HPRD, IntAct, MINT10101227 12167088 16007099 16824735 1922387 19527717 21988832 22327296 8654373 9596579 details
MK10_HUMANARRB1_HUMANBioGRID, IntAct, MINT11356842 19782076 19879840 details
MK10_HUMANARRB2_HUMANBioGRID, HPRD, MINT11090355 11356842 19782076 details
MK10_HUMANCBP_HUMANBioGRID, IntAct20936779 details
MK10_HUMANKI26A_HUMANBioGRID, IntAct20936779 details
MK10_HUMANCE290_HUMANBioGRID, IntAct20936779 details
MK10_HUMANTF65_HUMANBioGRID, IntAct21988832 details
MK10_HUMANTNIP1_HUMANBioGRID, IntAct21988832 details
MK10_HUMANHAX1_HUMANBioGRID, IntAct21988832 23602568 details
MK10_HUMANJUND_HUMANDIP22327296 details
MK10_HUMANLDHA_HUMANBioGRID, IntAct25416956 31515488 32296183 details
MK10_HUMANJIP3_HUMANBioGRID, HPRD10523642 10629060 12189133 details
MK10_HUMAN3BP5_HUMANBioGRID, HPRD12167088 details
MK10_HUMANJIP2_HUMANBioGRID10756100 details
MK10_HUMANMCL1_HUMANBioGRID17670986 details
MK10_HUMANHDAC9_HUMANBioGRID16611996 details
MK10_HUMANMP2K4_HUMANBioGRID, HPRD10715136 12788955 15299005 details
MK10_HUMANCDN1B_HUMANBioGRID12963725 details
MK10_HUMANA4_HUMANBioGRID21832049 details
MK10_HUMANATF2_HUMANBioGRID11865055 8654373 details
MK10_HUMANELK1_HUMANBioGRID8654373 details
MK10_HUMANPMYT1_HUMANBioGRID19204086 details
MK10_HUMANMK10_HUMANBioGRID19204086 23602568 details
MK10_HUMANCDN2A_HUMANBioGRID16007099 details
MK10_HUMANARF_HUMANBioGRID16007099 details
MK10_HUMANCDN2C_HUMANBioGRID16007099 details
MK10_HUMANDUS9_HUMANBioGRID9596579 details
MK10_HUMANFBX7_HUMANBioGRID27503909 details
MK10_HUMANTAU_HUMANBioGRID15228592 details
MK10_HUMANRASH_HUMANBioGRID30655611 details
MK10_HUMANKIF5A_HUMANBioGRID19525941 details
MK10_HUMANMABP1_HUMANHPRD10471813 details
MK10_HUMANUBE3A_HUMANMINT21653829 details
MK10_HUMANDUS1_HUMANBioGRID11359773 details
MK10_HUMANDUS10_HUMANBioGRID, HPRD11359773 details
MK10_HUMANDUS16_HUMANBioGRID, HPRD11359773 details
MK10_HUMANP53_HUMANBioGRID, HPRD9393873 details
MK10_HUMANHDAC1_HUMANBioGRID16611996 details
MK10_HUMANGCH1_HUMANBioGRID19294699 details
MK10_HUMANHNRPK_HUMANHPRD11231586 11259409 details
MK10_HUMANB2L11_HUMANHPRD12818176 details
MK10_HUMANSTMN2_HUMANHPRD11718727 details
MK10_HUMANCDK5_HUMANHPRD11823425 details