Entity Details

Primary name VAMP2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP63027
EntryNameVAMP2_HUMAN
FullNameVesicle-associated membrane protein 2
TaxID9606
Evidenceevidence at protein level
Length116
SequenceStatuscomplete
DateCreated2004-08-31
DateModified2021-06-02

Ontological Relatives

GenesVAMP2

GO terms

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GOName
GO:0000149 SNARE binding
GO:0005484 SNAP receptor activity
GO:0005516 calmodulin binding
GO:0005543 phospholipid binding
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006836 neurotransmitter transport
GO:0006887 exocytosis
GO:0006892 post-Golgi vesicle-mediated transport
GO:0006906 vesicle fusion
GO:0007269 neurotransmitter secretion
GO:0008021 synaptic vesicle
GO:0009749 response to glucose
GO:0015031 protein transport
GO:0016020 membrane
GO:0016079 synaptic vesicle exocytosis
GO:0016192 vesicle-mediated transport
GO:0017075 syntaxin-1 binding
GO:0017156 calcium-ion regulated exocytosis
GO:0017157 regulation of exocytosis
GO:0019905 syntaxin binding
GO:0030136 clathrin-coated vesicle
GO:0030141 secretory granule
GO:0030667 secretory granule membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0030672 synaptic vesicle membrane
GO:0031201 SNARE complex
GO:0031410 cytoplasmic vesicle
GO:0031982 vesicle
GO:0032869 cellular response to insulin stimulus
GO:0035493 SNARE complex assembly
GO:0042589 zymogen granule membrane
GO:0043001 Golgi to plasma membrane protein transport
GO:0043005 neuron projection
GO:0043231 intracellular membrane-bounded organelle
GO:0043308 eosinophil degranulation
GO:0043621 protein self-association
GO:0044306 neuron projection terminus
GO:0045048 protein insertion into ER membrane
GO:0045202 synapse
GO:0048306 calcium-dependent protein binding
GO:0048471 perinuclear region of cytoplasm
GO:0048488 synaptic vesicle endocytosis
GO:0060203 clathrin-sculpted glutamate transport vesicle membrane
GO:0060291 long-term synaptic potentiation
GO:0060627 regulation of vesicle-mediated transport
GO:0061024 membrane organization
GO:0061025 membrane fusion
GO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
GO:0065003 protein-containing complex assembly
GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex
GO:0070083 clathrin-sculpted monoamine transport vesicle membrane
GO:0090316 positive regulation of intracellular protein transport
GO:1902259 regulation of delayed rectifier potassium channel activity

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasmic vesicle

Domains

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DomainNameCategoryType
IPR001388 SynaptobrevinFamilyFamily
IPR016444 Synaptobrevin/Vesicle-associated membrane proteinFamilyFamily
IPR028717 Vesicle-associated membrane protein 2FamilyFamily
IPR042855 v-SNARE, coiled-coil homology domainDomainDomain

Diseases

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Disease IDSourceNameDescription
618760 OMIMNeurodevelopmental disorder with hypotonia and autistic features with or without hyperkinetic movements (NEDHAHM)An autosomal dominant disorder characterized by axial hypotonia apparent at birth, global developmental delay, intellectual disability, seizures, and autistic features. Involuntary hyperkinetic movements are present in some patients. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00042 Botulinum Toxin Type BDrugbankbiotech

Interactions

56 interactions

InteractorPartnerSourcesPublicationsLink
VAMP2_HUMANAT132_HUMANBioGRID, IntAct22645275 details
VAMP2_HUMANKPCD3_HUMANHPRD, IntAct17196367 details
VAMP2_HUMANSNP29_HUMANBioGRID, IntAct25416956 details
VAMP2_HUMANSTX4_HUMANBioGRID, HPRD, IntAct10194441 10820264 12417022 12517971 25416956 29360461 30217970 32296183 34079125 8760387 8770861 details
VAMP2_HUMANSTX2_HUMANBioGRID, IntAct12828989 29360461 32296183 details
VAMP2_HUMANKASH5_HUMANBioGRID, IntAct32296183 details
VAMP2_HUMANVMA21_HUMANBioGRID, IntAct32296183 details
VAMP2_HUMANDHB13_HUMANBioGRID, IntAct32296183 details
VAMP2_HUMANSTX1B_HUMANBioGRID, HPRD, IntAct12093152 32296183 details
VAMP2_HUMANSTX1A_HUMANBioGRID, HPRD, IntAct, UniProt10100611 10449403 11832227 12093152 20798282 32296183 7553862 9030619 details
VAMP2_HUMANCR3L1_HUMANBioGRID, IntAct32296183 details
VAMP2_HUMANZNT8_HUMANBioGRID, IntAct32296183 details
VAMP2_HUMANAQP6_HUMANBioGRID, IntAct32296183 details
VAMP2_HUMANCERS4_HUMANBioGRID, IntAct32296183 details
VAMP2_HUMANAR13B_HUMANBioGRID, IntAct32296183 details
VAMP2_HUMANS7A14_HUMANBioGRID, IntAct32296183 details
VAMP2_HUMANJAGN1_HUMANBioGRID, IntAct32296183 details
VAMP2_HUMANTM86B_HUMANBioGRID, IntAct32296183 details
VAMP2_HUMAN3HIDH_HUMANBioGRID, IntAct32296183 details
VAMP2_HUMANSCN3B_HUMANBioGRID, IntAct32296183 details
VAMP2_HUMANSTX3_HUMANBioGRID, IntAct12828989 26186194 28514442 29360461 details
VAMP2_HUMANDNJC5_HUMANBioGRID, IntAct29997244 details
VAMP2_HUMANEBP_HUMANBioGRID, IntAct32296183 details
VAMP2_HUMANSTX11_HUMANBioGRID, HPRD, IntAct10036234 28514442 details
VAMP2_HUMANSNP23_HUMANBioGRID, HPRD10713150 10820264 12828989 details
VAMP2_HUMANSNP25_HUMANBioGRID, DIP, HPRD, MINT, UniProt11524423 11832227 20798282 21785412 21785414 22890573 30610939 7961655 9030619 details
VAMP2_HUMANTM101_HUMANBioGRID, IntAct32296183 details
VAMP2_HUMANVAPA_HUMANBioGRID, HPRD22939629 9657962 details
VAMP2_HUMANMARH8_HUMANBioGRID, IntAct32296183 details
VAMP2_HUMANTERA_HUMANBioGRID, IntAct27762274 32814053 details
VAMP2_HUMANERGI3_HUMANBioGRID, IntAct32296183 details
VAMP2_HUMANVAMP3_HUMANBioGRID12130530 details
VAMP2_HUMANGET3_HUMANBioGRID20676083 details
VAMP2_HUMANVAPB_HUMANBioGRID, HPRD9920726 details
VAMP2_HUMANPRAF1_HUMANBioGRID, HPRD9341137 details
VAMP2_HUMANSNAA_HUMANBioGRID22939629 7622514 details
VAMP2_HUMANVAMP8_HUMANBioGRID, HPRD10336434 12130530 details
VAMP2_HUMANSYUA_HUMANUniProt20798282 details
VAMP2_HUMANBAG6_HUMANBioGRID20676083 details
VAMP2_HUMANLMNA_HUMANBioGRID24623722 details
VAMP2_HUMANTRPC3_HUMANHPRD15327778 details
VAMP2_HUMANEXOC3_HUMANBioGRID23897890 details
VAMP2_HUMANSTXB3_HUMANBioGRID12832401 details
VAMP2_HUMANBAP31_HUMANBioGRID9396746 details
VAMP2_HUMANFKBP2_HUMANBioGRID22956769 details
VAMP2_HUMANSC6A4_HUMANBioGRID24878716 details
VAMP2_HUMANTMM31_HUMANBioGRID32296183 details
VAMP2_HUMANSYPL1_HUMANBioGRID, HPRD, IntAct10370136 28514442 details
VAMP2_HUMANCPLX1_HUMANBioGRID, DIP, HPRD11832227 21785412 21785414 details
VAMP2_HUMANUN13B_HUMANBioGRID8999968 details
VAMP2_HUMANMLP3B_HUMANBioGRID27791468 details
VAMP2_HUMANSTXB2_HUMANHPRD12773094 details
VAMP2_HUMANHGS_HUMANBioGRID12847087 details
VAMP2_HUMANSYT1_HUMANBioGRID22890573 details
VAMP2_HUMANATP4A_HUMANBioGRID17255364 details
VAMP2_HUMANSYPH_HUMANHPRD12181340 12485399 details