Entity Details

Primary name SMOC2
Entity type gene
Source Source Link

Details

PrimaryID64094
RefseqGeneNG_032781
SymbolSMOC2
NameSPARC related modular calcium binding 2
Chromosome6
Location6q27
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-12-02
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsSMOC2_HUMAN

GO terms

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GOName
GO:0005509 calcium ion binding
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0008201 heparin binding
GO:0010595 positive regulation of endothelial cell migration
GO:0030198 extracellular matrix organization
GO:0035470 positive regulation of vascular wound healing
GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway
GO:0045766 positive regulation of angiogenesis
GO:0045931 positive regulation of mitotic cell cycle
GO:0050840 extracellular matrix binding
GO:0071944 cell periphery
GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway
GO:2000573 positive regulation of DNA biosynthetic process
GO:2001028 positive regulation of endothelial cell chemotaxis

Diseases

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Disease IDSourceNameDescription
125400 OMIMDentin dysplasia 1 (DTDP1)A dental defect in which both primary and secondary dentitions are affected. The clinical crowns of both permanent and deciduous teeth are of normal shape, form and color in most cases, although they may be slightly opalescent and blue or brown. Teeth may be very mobile and exfoliate spontaneously because of inadequate root formation. On radiographs, the roots are short and may be more pointed than normal. Pulp chambers are usually absent except for a chevron-shaped remnant in the crown. Root canals are usually absent. The disease is caused by variants affecting the gene represented in this entry.

Interactions

6 interactions

InteractorPartnerSourcesPublicationsLink
SMOC2KRTAP5-1BioGRID, IntAct32296183 details
SMOC2FBXO7BioGRID27503909 details
SMOC2TNCBioGRID21349332 details
SMOC2BANF1BioGRID19759913 details
SMOC2NR3C1BioGRID31182584 details
SMOC2HNRNPLBioGRID28611215 details