Entity Details

Primary name BCKD_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14874
EntryNameBCKD_HUMAN
FullName[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length412
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesBCKDK

GO terms

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GOName
GO:0004674 protein serine/threonine kinase activity
GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005524 ATP binding
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex
GO:0006468 protein phosphorylation
GO:0006550 isoleucine catabolic process
GO:0006552 leucine catabolic process
GO:0006574 valine catabolic process
GO:0007283 spermatogenesis
GO:0009063 cellular amino acid catabolic process
GO:0009083 branched-chain amino acid catabolic process
GO:0010906 regulation of glucose metabolic process
GO:0016301 kinase activity
GO:0016310 phosphorylation
GO:0045763 negative regulation of cellular amino acid metabolic process
GO:0047323 [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity

Subcellular Location

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Subcellular Location
Mitochondrion
Mitochondrion matrix

Domains

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DomainNameCategoryType
IPR003594 Histidine kinase/HSP90-like ATPaseDomainDomain
IPR004358 Signal transduction histidine kinase-related protein, C-terminalDomainDomain
IPR005467 Histidine kinase domainDomainDomain
IPR018955 Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminalDomainDomain
IPR036784 Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamilyFamilyHomologous superfamily
IPR036890 Histidine kinase/HSP90-like ATPase superfamilyFamilyHomologous superfamily
IPR039028 PDK/BCKDK protein kinaseFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB02930 Adenosine 5'-[gamma-thio]triphosphateDrugbanksmall molecule