Entity Details

Primary name PUR4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15067
EntryNamePUR4_HUMAN
FullNamePhosphoribosylformylglycinamidine synthase
TaxID9606
Evidenceevidence at protein level
Length1338
SequenceStatuscomplete
DateCreated2001-01-11
DateModified2021-06-02

Ontological Relatives

GenesPFAS

GO terms

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GOName
GO:0004642 phosphoribosylformylglycinamidine synthase activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0006189 'de novo' IMP biosynthetic process
GO:0006541 glutamine metabolic process
GO:0009168 purine ribonucleoside monophosphate biosynthetic process
GO:0042493 response to drug
GO:0046872 metal ion binding
GO:0070062 extracellular exosome
GO:0097065 anterior head development

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR010073 Phosphoribosylformylglycinamidine synthase PurLFamilyFamily
IPR010918 PurM-like, C-terminal domainDomainDomain
IPR017926 Glutamine amidotransferaseDomainDomain
IPR029062 Class I glutamine amidotransferase-likeFamilyHomologous superfamily
IPR036604 Phosphoribosylformylglycinamidine synthase subunit PurS-like superfamilyFamilyHomologous superfamily
IPR036676 PurM-like, C-terminal domain superfamilyFamilyHomologous superfamily
IPR036921 PurM-like, N-terminal domain superfamilyFamilyHomologous superfamily
IPR040707 Phosphoribosylformylglycinamidine synthase, N-terminalDomainDomain
IPR041609 Phosphoribosylformylglycinamidine synthase, linker domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00130 L-GlutamineDrugbanksmall molecule
DB00142 Glutamic acidDrugbanksmall molecule