Entity Details

Primary name SP16H_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y5B9
EntryNameSP16H_HUMAN
FullNameFACT complex subunit SPT16
TaxID9606
Evidenceevidence at protein level
Length1047
SequenceStatuscomplete
DateCreated2006-07-11
DateModified2021-06-02

Ontological Relatives

GenesSUPT16H

GO terms

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GOName
GO:0003723 RNA binding
GO:0005654 nucleoplasm
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006337 nucleosome disassembly
GO:0006366 transcription by RNA polymerase II
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0016032 viral process
GO:0031491 nucleosome binding
GO:0032786 positive regulation of DNA-templated transcription, elongation
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter
GO:0034724 DNA replication-independent nucleosome organization
GO:0035101 FACT complex
GO:1901796 regulation of signal transduction by p53 class mediator

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR000994 Peptidase M24DomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR013719 Domain of unknown function DUF1747DomainDomain
IPR013953 FACT complex subunit Spt16 domainDomainDomain
IPR029148 FACT complex subunit Spt16, N-terminal lobe domainDomainDomain
IPR029149 Creatinase/Aminopeptidase P/Spt16, N-terminalFamilyHomologous superfamily
IPR033825 FACT complex subunit Spt16, peptidase M24-like domainDomainDomain
IPR036005 Creatinase/aminopeptidase-likeFamilyHomologous superfamily
IPR040258 FACT complex subunit Spt16FamilyFamily

Diseases

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Interactions

45 interactions

InteractorPartnerSourcesPublicationsLink
SP16H_HUMANSSRP1_HUMANBioGRID, IntAct, MINT12393879 16682447 16713563 16902406 19214185 21055985 22863883 22939629 24981860 26344197 27173435 28514442 30021884 unassigned1312 details
SP16H_HUMANMCM4_HUMANBioGRID, HPRD, MINT16902406 details
SP16H_HUMANTCPZ_HUMANBioGRID, IntAct23414517 details
SP16H_HUMANSRPK2_HUMANBioGRID, IntAct23602568 details
SP16H_HUMANH2AX_HUMANBioGRID, IntAct, MINT16522924 18406329 24981860 28242625 28514442 details
SP16H_HUMANA4_HUMANIntAct32814053 details
SP16H_HUMANPARP1_HUMANBioGRID16682447 34079125 details
SP16H_HUMANSREK1_HUMANBioGRID, HPRD14559993 details
SP16H_HUMANSUMO2_HUMANBioGRID19394292 details
SP16H_HUMANOTUD5_HUMANBioGRID30508113 details
SP16H_HUMANT2EB_HUMANHPRD10792464 details
SP16H_HUMANVHL_HUMANIntAct17353931 details
SP16H_HUMANCRCM_HUMANIntAct17353931 details
SP16H_HUMANHLAB_HUMANIntAct17353931 details
SP16H_HUMANRPA49_HUMANBioGRID, MINT19214185 34079125 details
SP16H_HUMANRPA34_HUMANBioGRID, MINT19214185 34079125 details
SP16H_HUMANCDC5L_HUMANIntAct, MINT20467437 31413325 details
SP16H_HUMANTONSL_HUMANBioGRID, MINT21055985 21113133 25184681 details
SP16H_HUMANDPOLL_HUMANBioGRID, IntAct27173435 unassigned1312 details
SP16H_HUMANRFA3_HUMANBioGRID, IntAct27173435 unassigned1312 details
SP16H_HUMANWRN_HUMANBioGRID, IntAct27173435 unassigned1312 details
SP16H_HUMANCENPA_HUMANBioGRID, IntAct16622419 28514442 34079125 details
SP16H_HUMANH2A1_HUMANDIP, HPRD18206970 24463511 details
SP16H_HUMANPAF1_HUMANBioGRID16713563 22939629 24357716 26344197 details
SP16H_HUMANMRTFA_HUMANBioGRID18036521 details
SP16H_HUMANH33_HUMANBioGRID, HPRD15616580 17403666 details
SP16H_HUMANSP16H_HUMANBioGRID20603019 details
SP16H_HUMANMMS22_HUMANBioGRID21055985 details
SP16H_HUMANSMRCD_HUMANBioGRID21549307 26344197 details
SP16H_HUMANSOX2_HUMANBioGRID21280222 21532573 details
SP16H_HUMANUIF_HUMANBioGRID19836239 details
SP16H_HUMANPNKP_HUMANBioGRID15385968 details
SP16H_HUMANBRE1A_HUMANBioGRID24357716 details
SP16H_HUMANH2A1B_HUMANBioGRID18206970 27248496 details
SP16H_HUMANBRCA1_HUMANBioGRID25184681 26831064 details
SP16H_HUMANABCE1_HUMANBioGRID25659154 details
SP16H_HUMANUBR5_HUMANBioGRID27647897 30508113 details
SP16H_HUMANEZH2_HUMANBioGRID27634302 888800000289 details
SP16H_HUMANCSK22_HUMANBioGRID12393879 details
SP16H_HUMANBRD4_HUMANBioGRID32416067 888800000289 details
SP16H_HUMANDTX2_HUMANBioGRID32937373 details
SP16H_HUMANHDAC1_HUMANBioGRID888800000289 details
SP16H_HUMANISG15_HUMANBioGRID33024031 details
SP16H_HUMANNEK9_HUMANHPRD14660563 details
SP16H_HUMANMCM3_HUMANHPRD16902406 details