Entity Details

Primary name PNPH_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00491
EntryNamePNPH_HUMAN
FullNamePurine nucleoside phosphorylase
TaxID9606
Evidenceevidence at protein level
Length289
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesPNP

GO terms

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GOName
GO:0001882 nucleoside binding
GO:0002060 purine nucleobase binding
GO:0004731 purine-nucleoside phosphorylase activity
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006139 nucleobase-containing compound metabolic process
GO:0006148 inosine catabolic process
GO:0006166 purine ribonucleoside salvage
GO:0006195 purine nucleotide catabolic process
GO:0006204 IMP catabolic process
GO:0006738 nicotinamide riboside catabolic process
GO:0006955 immune response
GO:0009165 nucleotide biosynthetic process
GO:0032743 positive regulation of interleukin-2 production
GO:0034418 urate biosynthetic process
GO:0034774 secretory granule lumen
GO:0042102 positive regulation of T cell proliferation
GO:0042301 phosphate ion binding
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0043101 purine-containing compound salvage
GO:0043312 neutrophil degranulation
GO:0046059 dAMP catabolic process
GO:0046638 positive regulation of alpha-beta T cell differentiation
GO:0047975 guanosine phosphorylase activity
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000845 Nucleoside phosphorylase domainDomainDomain
IPR011268 Purine nucleoside phosphorylaseFamilyFamily
IPR011270 Purine nucleoside phosphorylase I, inosine/guanosine-specificFamilyFamily
IPR018099 Purine phosphorylase, family 2, conserved siteSiteConserved site
IPR035994 Nucleoside phosphorylase superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00242 CladribineDrugbanksmall molecule
DB00900 DidanosineDrugbanksmall molecule
DB01667 8-azaguanineDrugbanksmall molecule
DB02222 2,6-Diamino-(S)-9-[2-(Phosphonomethoxy)Propyl]PurineDrugbanksmall molecule
DB02230 Immucillin-GDrugbanksmall molecule
DB02377 GuanineDrugbanksmall molecule
DB02391 2-Amino-7-[2-(2-Hydroxy-1-Hydroxymethyl-Ethylamino)-Ethyl]-1,7-Dihydro-Purin-6-OneDrugbanksmall molecule
DB02568 PeldesineDrugbanksmall molecule
DB02796 9-deazainosineDrugbanksmall molecule
DB02857 GuanosineDrugbanksmall molecule
DB03101 Ribose-1-PhosphateDrugbanksmall molecule
DB03551 (3R,4R)-3-Hydroxy-4-(hydroxymethyl)-1-[(4-oxo-4,4a,5,7a-tetrahydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]pyrrolidiniumDrugbanksmall molecule
DB03609 3'-deoxyguanosineDrugbanksmall molecule
DB03881 (2S,3R,4S,5S)-3,4-Dihydroxy-2-[(methylsulfanyl)methyl]-5-(4-oxo-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)pyrrolidiniumDrugbanksmall molecule
DB04076 HypoxanthineDrugbanksmall molecule
DB04260 9-(5,5-Difluoro-5-Phosphonopentyl)GuanineDrugbanksmall molecule
DB04335 InosineDrugbanksmall molecule
DB04753 9-DEAZAINOSINE-2',3'-O-ETHYLIDENEPHOSPHONATEDrugbanksmall molecule
DB04754 GUANOSINE-2',3'-O-ETHYLIDENEPHOSPHONATEDrugbanksmall molecule
DB04757 GUANOSINE-2',3'-O-METHYLIDENEPHOSPHONATEDrugbanksmall molecule
DB06185 ForodesineDrugbanksmall molecule

Interactions

30 interactions

InteractorPartnerSourcesPublicationsLink
PNPH_HUMANAPLP1_HUMANBioGRID, HPRD, IntAct16169070 details
PNPH_HUMANCC90B_HUMANBioGRID, HPRD, IntAct16169070 details
PNPH_HUMANP53_HUMANBioGRID, HPRD, IntAct16169070 details
PNPH_HUMANZHX1_HUMANBioGRID, HPRD, IntAct16169070 details
PNPH_HUMANRBM48_HUMANBioGRID, HPRD, IntAct16169070 details
PNPH_HUMANCAPON_HUMANBioGRID, IntAct25814554 details
PNPH_HUMANPNPH_HUMANBioGRID, DIP, IntAct20212140 25416956 25502805 31515488 32296183 details
PNPH_HUMANKCC2A_HUMANIntAct32814053 details
PNPH_HUMANDC1I1_HUMANIntAct32814053 details
PNPH_HUMANFYN_HUMANIntAct32814053 details
PNPH_HUMANGFAP_HUMANIntAct32814053 details
PNPH_HUMANKAPCA_HUMANIntAct32814053 details
PNPH_HUMANRAC1_HUMANIntAct32814053 details
PNPH_HUMANSORL_HUMANIntAct32814053 details
PNPH_HUMANTGIF1_HUMANIntAct32814053 details
PNPH_HUMANKAT5_HUMANIntAct32814053 details
PNPH_HUMANPINK1_HUMANIntAct32814053 details
PNPH_HUMANA4_HUMANIntAct32814053 details
PNPH_HUMANLRIF1_HUMANBioGRID, HPRD16169070 details
PNPH_HUMANUCHL5_HUMANBioGRID21800051 details
PNPH_HUMANRIF1_HUMANIntAct16169070 details
PNPH_HUMANCRCM_HUMANIntAct17353931 details
PNPH_HUMANHLAB_HUMANIntAct17353931 details
PNPH_HUMANEPB41_HUMANIntAct17353931 details
PNPH_HUMANIKKE_HUMANIntAct17353931 details
PNPH_HUMANABCE1_HUMANBioGRID25659154 details
PNPH_HUMANDERL1_HUMANBioGRID28137758 details
PNPH_HUMANTFAM_HUMANHPRD12068295 details
PNPH_HUMANNCALD_HUMANHPRD11964161 details
PNPH_HUMANTFB2M_HUMANHPRD12068295 details