Entity Details

Primary name UCHL1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP09936
EntryNameUCHL1_HUMAN
FullNameUbiquitin carboxyl-terminal hydrolase isozyme L1
TaxID9606
Evidenceevidence at protein level
Length223
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesUCHL1

GO terms

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GOName
GO:0004197 cysteine-type endopeptidase activity
GO:0004843 thiol-dependent deubiquitinase
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0008242 omega peptidase activity
GO:0016241 regulation of macroautophagy
GO:0016579 protein deubiquitination
GO:0016874 ligase activity
GO:0031625 ubiquitin protein ligase binding
GO:0031694 alpha-2A adrenergic receptor binding
GO:0043130 ubiquitin binding
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043407 negative regulation of MAP kinase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR001578 Peptidase C12, ubiquitin carboxyl-terminal hydrolaseDomainDomain
IPR030297 Ubiquitin carboxyl-terminal hydrolase L1FamilyFamily
IPR036959 Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamilyFamilyHomologous superfamily
IPR038765 Papain-like cysteine peptidase superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12695 Phenethyl IsothiocyanateDrugbanksmall molecule

Interactions

95 interactions

InteractorPartnerSourcesPublicationsLink
UCHL1_HUMANCBX1_HUMANBioGRID, HPRD, IntAct16169070 32814053 details
UCHL1_HUMANNEDD8_HUMANBioGRID, HPRD, IntAct16169070 32814053 details
UCHL1_HUMANA4_HUMANBioGRID, IntAct16049941 25466238 32814053 details
UCHL1_HUMANEIF1B_HUMANIntAct17353931 32814053 details
UCHL1_HUMANATG5_HUMANIntAct17353931 32814053 details
UCHL1_HUMANTRAF6_HUMANBioGRID, IntAct17353931 23717208 32814053 details
UCHL1_HUMANIKKE_HUMANIntAct17353931 32814053 details
UCHL1_HUMANCSN5_HUMANBioGRID, HPRD, IntAct12082530 details
UCHL1_HUMANUBC9_HUMANBioGRID, HPRD, IntAct12082530 details
UCHL1_HUMANRANB9_HUMANBioGRID, HPRD, IntAct12082530 details
UCHL1_HUMANCDN1B_HUMANBioGRID, HPRD, IntAct12082530 details
UCHL1_HUMANUBP21_HUMANBioGRID, IntAct19615732 22626734 32814053 details
UCHL1_HUMANEGFR_HUMANBioGRID, IntAct20029029 31980649 32042339 32494592 details
UCHL1_HUMANNCAM1_HUMANBioGRID, MINT23061666 details
UCHL1_HUMANAKT1_HUMANBioGRID, MINT16027165 25640309 details
UCHL1_HUMANTE2IP_HUMANbhf-ucl, BioGRID21044950 29126443 details
UCHL1_HUMANTINF2_HUMANbhf-ucl, BioGRID21044950 details
UCHL1_HUMANPDZ1I_HUMANIntAct32814053 details
UCHL1_HUMANCSN3_HUMANIntAct32814053 details
UCHL1_HUMANRN112_HUMANIntAct32814053 details
UCHL1_HUMANBRK1_HUMANIntAct32814053 details
UCHL1_HUMANP53_HUMANBioGRID, IntAct18666234 20395212 29126443 32814053 details
UCHL1_HUMANTERF2_HUMANBioGRID, IntAct29126443 32814053 details
UCHL1_HUMANRO52_HUMANIntAct32814053 details
UCHL1_HUMANRAN_HUMANIntAct32814053 details
UCHL1_HUMANNVL_HUMANIntAct32814053 details
UCHL1_HUMANLAMP2_HUMANBioGRID, HPRD, IntAct18550537 18635949 32814053 details
UCHL1_HUMANUBE2K_HUMANIntAct32814053 details
UCHL1_HUMANATF3_HUMANIntAct32814053 details
UCHL1_HUMANBIRC5_HUMANIntAct32814053 details
UCHL1_HUMANAP2B1_HUMANIntAct32814053 details
UCHL1_HUMANIQEC1_HUMANIntAct32814053 details
UCHL1_HUMANUBAC1_HUMANIntAct32814053 details
UCHL1_HUMANLMBL3_HUMANIntAct32814053 details
UCHL1_HUMANNIPA_HUMANIntAct32814053 details
UCHL1_HUMANLSM8_HUMANIntAct32814053 details
UCHL1_HUMANARFG1_HUMANIntAct32814053 details
UCHL1_HUMANEVL_HUMANIntAct32814053 details
UCHL1_HUMANENKUR_HUMANIntAct32814053 details
UCHL1_HUMANREBL1_HUMANIntAct32814053 details
UCHL1_HUMANHNRLL_HUMANIntAct32814053 details
UCHL1_HUMANLDH6B_HUMANIntAct32814053 details
UCHL1_HUMANUBC_HUMANBioGRID, HPRD16169070 20439756 20622874 22284438 23801757 2532544 27066941 27501351 28338014 28935764 29576527 31494268 9521656 details
UCHL1_HUMANSMN_HUMANBioGRID20713032 details
UCHL1_HUMANHSP7C_HUMANBioGRID, HPRD18550537 18635949 details
UCHL1_HUMANHS90A_HUMANBioGRID, HPRD18550537 18635949 32120844 details
UCHL1_HUMANADA2A_HUMANBioGRID19477270 details
UCHL1_HUMANADA2B_HUMANBioGRID19477270 details
UCHL1_HUMANADA2C_HUMANBioGRID19477270 details
UCHL1_HUMANADRB2_HUMANBioGRID19477270 details
UCHL1_HUMANTRI63_HUMANBioGRID22626734 details
UCHL1_HUMANTRI54_HUMANBioGRID22626734 details
UCHL1_HUMANUBP15_HUMANBioGRID22626734 details
UCHL1_HUMANUBP28_HUMANBioGRID22626734 details
UCHL1_HUMANTNR1A_HUMANBioGRID24980434 details
UCHL1_HUMANPA2GA_HUMANBioGRID22118674 details
UCHL1_HUMANPRKN_HUMANBioGRID25403879 details
UCHL1_HUMANAKT2_HUMANBioGRID28636190 details
UCHL1_HUMANUBB_HUMANIntAct16169070 details
UCHL1_HUMANVHL_HUMANIntAct17353931 details
UCHL1_HUMANIF6_HUMANIntAct17353931 details
UCHL1_HUMANCRCM_HUMANIntAct17353931 details
UCHL1_HUMANTNIK_HUMANIntAct17353931 details
UCHL1_HUMANFMR1_HUMANIntAct31413325 details
UCHL1_HUMANMYCB2_HUMANMINT21653829 details
UCHL1_HUMANSHAN3_HUMANMINT21653829 details
UCHL1_HUMANCTNB1_HUMANBioGRID19536331 details
UCHL1_HUMANMDM2_HUMANBioGRID20395212 details
UCHL1_HUMANCDN2A_HUMANBioGRID20395212 details
UCHL1_HUMANARF_HUMANBioGRID20395212 details
UCHL1_HUMANTBA1A_HUMANBioGRID18250096 details
UCHL1_HUMANDDB1_HUMANBioGRID23297343 details
UCHL1_HUMANRPTOR_HUMANBioGRID23297343 details
UCHL1_HUMANCDK1_HUMANBioGRID23543736 details
UCHL1_HUMANCDK4_HUMANBioGRID23543736 details
UCHL1_HUMANCDK5_HUMANBioGRID23543736 details
UCHL1_HUMANCDK6_HUMANBioGRID23543736 details
UCHL1_HUMANAPR_HUMANBioGRID23499448 details
UCHL1_HUMANTRAF3_HUMANBioGRID23717208 details
UCHL1_HUMANNMRL1_HUMANBioGRID24763515 details
UCHL1_HUMANDERL1_HUMANBioGRID28137758 details
UCHL1_HUMANMITF_HUMANBioGRID28392346 details
UCHL1_HUMANAIP_HUMANBioGRID31042473 details
UCHL1_HUMANBCL6_HUMANBioGRID31042473 details
UCHL1_HUMANCCNB1_HUMANBioGRID31906456 details
UCHL1_HUMANSRC8_HUMANBioGRID32120844 details
UCHL1_HUMANANXA6_HUMANBioGRID32606430 details
UCHL1_HUMANBIP_HUMANBioGRID32606430 details
UCHL1_HUMANCPT1B_HUMANBioGRID32606430 details
UCHL1_HUMANPYGB_HUMANBioGRID32606430 details
UCHL1_HUMANEFTU_HUMANBioGRID32606430 details
UCHL1_HUMANCSRP3_HUMANBioGRID32606430 details
UCHL1_HUMANSMAD2_HUMANBioGRID32371398 details
UCHL1_HUMANSMAD3_HUMANBioGRID32371398 details
UCHL1_HUMANSMAD4_HUMANBioGRID32371398 details