Entity Details

Primary name TGM1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP22735
EntryNameTGM1_HUMAN
FullNameProtein-glutamine gamma-glutamyltransferase K
TaxID9606
Evidenceevidence at protein level
Length817
SequenceStatuscomplete
DateCreated1991-08-01
DateModified2021-06-02

Ontological Relatives

GenesTGM1

GO terms

Show/Hide Table
GOName
GO:0001533 cornified envelope
GO:0003810 protein-glutamine gamma-glutamyltransferase activity
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006464 cellular protein modification process
GO:0010838 positive regulation of keratinocyte proliferation
GO:0016020 membrane
GO:0018149 peptide cross-linking
GO:0030216 keratinocyte differentiation
GO:0031224 intrinsic component of membrane
GO:0042802 identical protein binding
GO:0043163 cell envelope organization
GO:0045787 positive regulation of cell cycle
GO:0046872 metal ion binding
GO:0070062 extracellular exosome
GO:0070268 cornification

Subcellular Location

Show/Hide Table
Subcellular Location
Membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR001102 Transglutaminase, N-terminalDomainDomain
IPR002931 Transglutaminase-likeDomainDomain
IPR008958 Transglutaminase, C-terminalDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR013808 Transglutaminase, active siteSiteActive site
IPR014756 Immunoglobulin E-setFamilyHomologous superfamily
IPR023608 Protein-glutamine gamma-glutamyltransferase, animalFamilyFamily
IPR036238 Transglutaminase, C-terminal domain superfamilyFamilyHomologous superfamily
IPR036985 Transglutaminase-like superfamilyFamilyHomologous superfamily
IPR038765 Papain-like cysteine peptidase superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00130 L-GlutamineDrugbanksmall molecule

Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
TGM1_HUMANRIN3_HUMANBioGRID, IntAct25814554 details
TGM1_HUMANLCE3A_HUMANBioGRID, IntAct32296183 details
TGM1_HUMANKR412_HUMANBioGRID, IntAct32296183 details
TGM1_HUMANLCE4A_HUMANBioGRID, IntAct32296183 details
TGM1_HUMANLCE1E_HUMANBioGRID, IntAct32296183 details
TGM1_HUMANPPB1_HUMANBioGRID, IntAct32296183 details
TGM1_HUMANITB4_HUMANBioGRID, IntAct32296183 details
TGM1_HUMANKRA59_HUMANBioGRID, IntAct32296183 details
TGM1_HUMANVSTM4_HUMANBioGRID, IntAct32296183 details
TGM1_HUMANST4A1_HUMANBioGRID, IntAct32296183 details
TGM1_HUMANSREC_HUMANBioGRID, IntAct32296183 details
TGM1_HUMANNUBP2_HUMANBioGRID, IntAct32296183 details
TGM1_HUMANACADL_HUMANBioGRID, IntAct32296183 details
TGM1_HUMANTGM1_HUMANBioGRID, IntAct32296183 details
TGM1_HUMANIGSF8_HUMANBioGRID, IntAct32296183 details
TGM1_HUMANDOCK2_HUMANBioGRID, IntAct32296183 details
TGM1_HUMANCRCT1_HUMANBioGRID, IntAct32296183 details
TGM1_HUMANGILT_HUMANBioGRID, IntAct32296183 details
TGM1_HUMANNECT2_HUMANBioGRID, IntAct32296183 details
TGM1_HUMANJOS1_HUMANBioGRID, IntAct32296183 details
TGM1_HUMANC1QT1_HUMANBioGRID, IntAct32296183 details
TGM1_HUMANLCE1B_HUMANBioGRID, IntAct32296183 details
TGM1_HUMANTPC14_HUMANBioGRID, IntAct32296183 details
TGM1_HUMANCNNM3_HUMANBioGRID, IntAct32296183 details
TGM1_HUMANGSTP1_HUMANBioGRID, IntAct32296183 details
TGM1_HUMANMYPOP_HUMANBioGRID, IntAct32296183 details
TGM1_HUMANVASN_HUMANBioGRID, IntAct32296183 details
TGM1_HUMANCASP6_HUMANIntAct32814053 details
TGM1_HUMANLAMP2_HUMANIntAct32814053 details
TGM1_HUMANSHLB1_HUMANIntAct32814053 details
TGM1_HUMANPR40A_HUMANIntAct32814053 details
TGM1_HUMANSYUA_HUMANBioGRID19651786 details
TGM1_HUMANTACC2_HUMANBioGRID32296183 details
TGM1_HUMANCXL16_HUMANBioGRID32296183 details
TGM1_HUMANLOXE3_HUMANIntAct22622417 details
TGM1_HUMANLX12B_HUMANIntAct22622417 details
TGM1_HUMANSEMG1_HUMANHPRD9523691 details
TGM1_HUMANSEMG2_HUMANHPRD9523691 details
TGM1_HUMANHSPB1_HUMANHPRD12100179 details
TGM1_HUMANPLAT4_HUMANHPRD15846304 details
TGM1_HUMANMK_HUMANHPRD9384573 details