Entity Details

Primary name METK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP31153
EntryNameMETK2_HUMAN
FullNameS-adenosylmethionine synthase isoform type-2
TaxID9606
Evidenceevidence at protein level
Length395
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesMAT2A

GO terms

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GOName
GO:0004478 methionine adenosyltransferase activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0006556 S-adenosylmethionine biosynthetic process
GO:0006730 one-carbon metabolic process
GO:0032259 methylation
GO:0034214 protein hexamerization
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0048269 methionine adenosyltransferase complex
GO:0051291 protein heterooligomerization
GO:1990830 cellular response to leukemia inhibitory factor

Subcellular Location

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Domains

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DomainNameCategoryType
IPR002133 S-adenosylmethionine synthetaseFamilyFamily
IPR022628 S-adenosylmethionine synthetase, N-terminalDomainDomain
IPR022629 S-adenosylmethionine synthetase, central domainDomainDomain
IPR022630 S-adenosylmethionine synthetase, C-terminalDomainDomain
IPR022631 S-adenosylmethionine synthetase, conserved siteSiteConserved site
IPR022636 S-adenosylmethionine synthetase superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00118 AdemetionineDrugbanksmall molecule
DB00134 MethionineDrugbanksmall molecule

Interactions

36 interactions

InteractorPartnerSourcesPublicationsLink
METK2_HUMANCUL3_HUMANBioGRID, IntAct21145461 27213918 details
METK2_HUMANMAT2B_HUMANBioGRID, HPRD, IntAct12671891 21516116 22863883 25416956 26186194 26344197 27548429 28514442 details
METK2_HUMANMETK2_HUMANBioGRID, IntAct25416956 27548429 32296183 details
METK2_HUMANMETK1_HUMANBioGRID, IntAct22939629 26186194 28514442 32296183 details
METK2_HUMANPRC1_HUMANBioGRID, IntAct32296183 details
METK2_HUMANF117B_HUMANIntAct32814053 details
METK2_HUMANBOD1_HUMANIntAct32814053 details
METK2_HUMANKCC1G_HUMANIntAct32814053 details
METK2_HUMANRBM11_HUMANIntAct32814053 details
METK2_HUMANPELO_HUMANIntAct32814053 details
METK2_HUMANCRLF3_HUMANIntAct32814053 details
METK2_HUMANKLF15_HUMANIntAct32814053 details
METK2_HUMANRYBP_HUMANIntAct32814053 details
METK2_HUMANSNW1_HUMANIntAct32814053 details
METK2_HUMANZMYM6_HUMANIntAct32814053 details
METK2_HUMAN4F2_HUMANIntAct32814053 details
METK2_HUMANAAKB2_HUMANIntAct32814053 details
METK2_HUMANMT2_HUMANIntAct32814053 details
METK2_HUMANIN35_HUMANIntAct32814053 details
METK2_HUMANGATA1_HUMANIntAct32814053 details
METK2_HUMANCC141_HUMANIntAct32814053 details
METK2_HUMANBACD1_HUMANIntAct32814053 details
METK2_HUMANSPA24_HUMANIntAct32814053 details
METK2_HUMANHGS_HUMANBioGRID19019082 details
METK2_HUMANTM213_HUMANBioGRID25416956 details
METK2_HUMANUBC9_HUMANBioGRID26416353 details
METK2_HUMANOGT1_HUMANBioGRID32994395 details
METK2_HUMANARF6_HUMANIntAct17353931 details
METK2_HUMANARP6_HUMANIntAct17353931 details
METK2_HUMANAAKB1_HUMANIntAct17353931 details
METK2_HUMANIKKE_HUMANIntAct17353931 details
METK2_HUMANTRAF6_HUMANIntAct17353931 details
METK2_HUMANSAP18_HUMANIntAct17353931 details
METK2_HUMANMT21D_HUMANBioGRID23349634 details
METK2_HUMANBCL2_HUMANBioGRID26416353 details
METK2_HUMANFGF11_HUMANBioGRID28027390 details