Entity Details

Primary name BMX_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP51813
EntryNameBMX_HUMAN
FullNameCytoplasmic tyrosine-protein kinase BMX
TaxID9606
Evidenceevidence at protein level
Length675
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesBMX

GO terms

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GOName
GO:0002250 adaptive immune response
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006915 apoptotic process
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007498 mesoderm development
GO:0032587 ruffle membrane
GO:0035556 intracellular signal transduction
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0050853 B cell receptor signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001562 Zinc finger, Btk motifSiteConserved site
IPR001849 Pleckstrin homology domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR028840 Cytoplasmic tyrosine-protein kinase BMXFamilyFamily
IPR035875 BMX, SH2 domainDomainDomain
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule
DB15035 ZanubrutinibDrugbanksmall molecule

Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
BMX_HUMANERBB2_HUMANBioGRID, MINT16273093 details
BMX_HUMANEGFR_HUMANBioGRID, MINT16273093 details
BMX_HUMANCRK_HUMANIntAct17474147 details
BMX_HUMANNOPC1_HUMANBioGRID, IntAct21988832 details
BMX_HUMANSTAT3_HUMANBioGRID, HPRD, IntAct10688651 21516116 25416956 25814554 31515488 32296183 details
BMX_HUMANCLNK_HUMANBioGRID, IntAct25814554 details
BMX_HUMANPTN21_HUMANBioGRID, HPRD, IntAct11013262 32296183 details
BMX_HUMANBIRC2_HUMANBioGRID, IntAct32296183 details
BMX_HUMANPTPRD_HUMANBioGRID, MINT22305495 details
BMX_HUMANFAK1_HUMANBioGRID11331870 details
BMX_HUMANCASP3_HUMANBioGRID, HPRD11278797 details
BMX_HUMANRUFY1_HUMANBioGRID, HPRD11877430 details
BMX_HUMANRUFY2_HUMANBioGRID, HPRD11877430 details
BMX_HUMANPAK1_HUMANBioGRID, HPRD11382770 details
BMX_HUMANA4_HUMANBioGRID21832049 details
BMX_HUMANBCAR1_HUMANBioGRID22974441 details
BMX_HUMANFBX25_HUMANBioGRID23940030 details
BMX_HUMANRAP1A_HUMANBioGRID, HPRD15207703 details
BMX_HUMANPIM1_HUMANIntAct16186805 details
BMX_HUMANP53_HUMANIntAct16186805 details
BMX_HUMANHS90B_HUMANBioGRID, IntAct22939624 31980649 details
BMX_HUMANCAV1_HUMANBioGRID, HPRD11751885 details
BMX_HUMANSRC_HUMANBioGRID, HPRD10688651 details
BMX_HUMANELP1_HUMANBioGRID18303054 details
BMX_HUMANITK_HUMANHPRD12573241 details
BMX_HUMANBTK_HUMANHPRD12573241 details
BMX_HUMANSTAT1_HUMANHPRD9373245 details
BMX_HUMANTEC_HUMANHPRD12573241 details
BMX_HUMANSTA5A_HUMANHPRD9373245 details
BMX_HUMANTNR1B_HUMANHPRD12370298 details
BMX_HUMANVGFR2_HUMANHPRD14532277 details