Entity Details

Primary name AT12A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP54707
EntryNameAT12A_HUMAN
FullNamePotassium-transporting ATPase alpha chain 2
TaxID9606
Evidenceevidence at protein level
Length1039
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesATP12A

GO terms

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GOName
GO:0005391 P-type sodium:potassium-exchanging transporter activity
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0005889 potassium:proton exchanging ATPase complex
GO:0006883 cellular sodium ion homeostasis
GO:0008900 P-type potassium:proton transporter activity
GO:0016324 apical plasma membrane
GO:0030007 cellular potassium ion homeostasis
GO:0034220 ion transmembrane transport
GO:0036376 sodium ion export across plasma membrane
GO:0046872 metal ion binding
GO:1902600 proton transmembrane transport
GO:1990573 potassium ion import across plasma membrane

Subcellular Location

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Subcellular Location
Apical cell membrane

Domains

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DomainNameCategoryType
IPR001757 P-type ATPaseFamilyFamily
IPR004014 Cation-transporting P-type ATPase, N-terminalDomainDomain
IPR005775 P-type ATPase subfamily IIC, subunit alphaFamilyFamily
IPR006068 Cation-transporting P-type ATPase, C-terminalDomainDomain
IPR008250 P-type ATPase, A domain superfamilyFamilyHomologous superfamily
IPR018303 P-type ATPase, phosphorylation sitePTMPTM
IPR023214 HAD superfamilyFamilyHomologous superfamily
IPR023298 P-type ATPase, transmembrane domain superfamilyFamilyHomologous superfamily
IPR023299 P-type ATPase, cytoplasmic domain NFamilyHomologous superfamily
IPR030318 Potassium-transporting ATPase alpha chain 2FamilyFamily
IPR036412 HAD-like superfamilyFamilyHomologous superfamily
IPR044492 P-type ATPase, haloacid dehalogenase domainDomainDomain

Diseases

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Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
AT12A_HUMANGNAI3_HUMANBioGRID, IntAct21988832 details
AT12A_HUMANPPIB_HUMANBioGRID, IntAct21988832 details
AT12A_HUMANNPY_HUMANBioGRID, IntAct21988832 details