Entity Details

Primary name GBRE_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP78334
EntryNameGBRE_HUMAN
FullNameGamma-aminobutyric acid receptor subunit epsilon
TaxID9606
Evidenceevidence at transcript level
Length506
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesGABRE

GO terms

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GOName
GO:0004890 GABA-A receptor activity
GO:0005237 inhibitory extracellular ligand-gated ion channel activity
GO:0005887 integral component of plasma membrane
GO:0007165 signal transduction
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0007268 chemical synaptic transmission
GO:0022851 GABA-gated chloride ion channel activity
GO:0030594 neurotransmitter receptor activity
GO:0032590 dendrite membrane
GO:0034220 ion transmembrane transport
GO:0034707 chloride channel complex
GO:0042391 regulation of membrane potential
GO:0043005 neuron projection
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0050877 nervous system process
GO:0051932 synaptic transmission, GABAergic
GO:0060078 regulation of postsynaptic membrane potential
GO:0098794 postsynapse
GO:1902476 chloride transmembrane transport
GO:1902711 GABA-A receptor complex
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
GO:2001226 negative regulation of chloride transport

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane

Domains

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DomainNameCategoryType
IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alphaFamilyFamily
IPR006029 Neurotransmitter-gated ion-channel transmembrane domainDomainDomain
IPR006201 Neurotransmitter-gated ion-channelFamilyFamily
IPR006202 Neurotransmitter-gated ion-channel ligand-binding domainDomainDomain
IPR008099 Gamma-aminobutyric-acid A receptor epsilon subunitFamilyFamily
IPR018000 Neurotransmitter-gated ion-channel, conserved siteSiteConserved site
IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamilyFamilyHomologous superfamily
IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00186 LorazepamDrugbanksmall molecule
DB00189 EthchlorvynolDrugbanksmall molecule
DB00228 EnfluraneDrugbanksmall molecule
DB00231 TemazepamDrugbanksmall molecule
DB00237 ButabarbitalDrugbanksmall molecule
DB00241 ButalbitalDrugbanksmall molecule
DB00252 PhenytoinDrugbanksmall molecule
DB00292 EtomidateDrugbanksmall molecule
DB00306 TalbutalDrugbanksmall molecule
DB00312 PentobarbitalDrugbanksmall molecule
DB00349 ClobazamDrugbanksmall molecule
DB00371 MeprobamateDrugbanksmall molecule
DB00402 EszopicloneDrugbanksmall molecule
DB00404 AlprazolamDrugbanksmall molecule
DB00463 MetharbitalDrugbanksmall molecule
DB00475 ChlordiazepoxideDrugbanksmall molecule
DB00543 AmoxapineDrugbanksmall molecule
DB00546 AdinazolamDrugbanksmall molecule
DB00555 LamotrigineDrugbanksmall molecule
DB00603 Medroxyprogesterone acetateDrugbanksmall molecule
DB00628 Clorazepic acidDrugbanksmall molecule
DB00659 AcamprosateDrugbanksmall molecule
DB00683 MidazolamDrugbanksmall molecule
DB00690 FlurazepamDrugbanksmall molecule
DB00753 IsofluraneDrugbanksmall molecule
DB00794 PrimidoneDrugbanksmall molecule
DB00801 HalazepamDrugbanksmall molecule
DB00818 PropofolDrugbanksmall molecule
DB00829 DiazepamDrugbanksmall molecule
DB00842 OxazepamDrugbanksmall molecule
DB00897 TriazolamDrugbanksmall molecule
DB00898 EthanolDrugbanksmall molecule
DB01028 MethoxyfluraneDrugbanksmall molecule
DB01043 MemantineDrugbanksmall molecule
DB01068 ClonazepamDrugbanksmall molecule
DB01107 MethyprylonDrugbanksmall molecule
DB01159 HalothaneDrugbanksmall molecule
DB01189 DesfluraneDrugbanksmall molecule
DB01205 FlumazenilDrugbanksmall molecule
DB01215 EstazolamDrugbanksmall molecule
DB01236 SevofluraneDrugbanksmall molecule
DB01437 GlutethimideDrugbanksmall molecule
DB01489 CamazepamDrugbanksmall molecule
DB01511 DelorazepamDrugbanksmall molecule
DB01544 FlunitrazepamDrugbanksmall molecule
DB01545 Ethyl loflazepateDrugbanksmall molecule
DB01553 CloxazolamDrugbanksmall molecule
DB01558 BromazepamDrugbanksmall molecule
DB01559 ClotiazepamDrugbanksmall molecule
DB01567 FludiazepamDrugbanksmall molecule
DB01587 KetazolamDrugbanksmall molecule
DB01588 PrazepamDrugbanksmall molecule
DB01589 QuazepamDrugbanksmall molecule
DB01594 CinolazepamDrugbanksmall molecule
DB01595 NitrazepamDrugbanksmall molecule
DB01708 PrasteroneDrugbanksmall molecule
DB01956 TaurineDrugbanksmall molecule
DB09017 BrotizolamDrugbanksmall molecule
DB09118 StiripentolDrugbanksmall molecule
DB09166 EtizolamDrugbanksmall molecule
DB11582 ThiocolchicosideDrugbanksmall molecule
DB11859 BrexanoloneDrugbanksmall molecule
DB11901 ApalutamideDrugbanksmall molecule
DB12404 RemimazolamDrugbanksmall molecule
DB12537 BenzodiazepineDrugbanksmall molecule
DB13335 PinazepamDrugbanksmall molecule
DB13437 MedazepamDrugbanksmall molecule
DB13643 LoprazolamDrugbanksmall molecule
DB13837 DoxefazepamDrugbanksmall molecule
DB13872 LormetazepamDrugbanksmall molecule
DB14028 NordazepamDrugbanksmall molecule
DB14672 Oxazepam acetateDrugbanksmall molecule
DB14715 CinazepamDrugbanksmall molecule
DB14719 BentazepamDrugbanksmall molecule
DB15489 MexazolamDrugbanksmall molecule

Interactions

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