Entity Details

Primary name TLR3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15455
EntryNameTLR3_HUMAN
FullNameToll-like receptor 3
TaxID9606
Evidenceevidence at protein level
Length904
SequenceStatuscomplete
DateCreated2002-01-31
DateModified2021-06-02

Ontological Relatives

GenesTLR3

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001774 microglial cell activation
GO:0002224 toll-like receptor signaling pathway
GO:0002730 regulation of dendritic cell cytokine production
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0003725 double-stranded RNA binding
GO:0004888 transmembrane signaling receptor activity
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005769 early endosome
GO:0005789 endoplasmic reticulum membrane
GO:0005887 integral component of plasma membrane
GO:0006954 inflammatory response
GO:0006972 hyperosmotic response
GO:0007165 signal transduction
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0007252 I-kappaB phosphorylation
GO:0008584 male gonad development
GO:0009597 detection of virus
GO:0010008 endosome membrane
GO:0010628 positive regulation of gene expression
GO:0016020 membrane
GO:0031012 extracellular matrix
GO:0032722 positive regulation of chemokine production
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0032729 positive regulation of interferon-gamma production
GO:0032735 positive regulation of interleukin-12 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034123 positive regulation of toll-like receptor signaling pathway
GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034346 positive regulation of type III interferon production
GO:0035458 cellular response to interferon-beta
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0035690 cellular response to drug
GO:0036020 endolysosome membrane
GO:0038023 signaling receptor activity
GO:0042742 defense response to bacterium
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330 response to exogenous dsRNA
GO:0043331 response to dsRNA
GO:0045087 innate immune response
GO:0045671 negative regulation of osteoclast differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046330 positive regulation of JNK cascade
GO:0050729 positive regulation of inflammatory response
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051607 defense response to virus
GO:0070266 necroptotic process
GO:0071260 cellular response to mechanical stimulus
GO:0071346 cellular response to interferon-gamma
GO:0071360 cellular response to exogenous dsRNA
GO:0097190 apoptotic signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097527 necroptotic signaling pathway
GO:1901224 positive regulation of NIK/NF-kappaB signaling

Subcellular Location

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Subcellular Location
Early endosome
Endoplasmic reticulum membrane
Endosome membrane

Domains

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DomainNameCategoryType
IPR000157 Toll/interleukin-1 receptor homology (TIR) domainDomainDomain
IPR000483 Cysteine-rich flanking region, C-terminalDomainDomain
IPR001611 Leucine-rich repeatRepeatRepeat
IPR003591 Leucine-rich repeat, typical subtypeRepeatRepeat
IPR017241 Toll-like receptorFamilyFamily
IPR027173 Toll-like receptor 3FamilyFamily
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamilyFamilyHomologous superfamily
IPR041015 Toll-like receptor 3 trans-membrane domainDomainDomain

Diseases

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Disease IDSourceNameDescription
613002 OMIMEncephalopathy, acute, infection-induced, Herpes-specific, 2 (IIAE2)A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. It is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. Disease susceptibility is associated with variants affecting the gene represented in this entry. TLR3 mutations predispose otherwise healthy individuals to isolated herpes simplex encephalitis through a mechanism that involves impaired IFNs production and reduced immune defense against viral infection in the central nervous system.

Interactions

42 interactions

InteractorPartnerSourcesPublicationsLink
TLR3_HUMANCHK2_HUMANBioGRID, MINT25640309 details
TLR3_HUMANTLR3_HUMANDIP, HPRD, IntAct, MINT15107846 18172197 23155421 25217833 details
TLR3_HUMANSIGL5_HUMANIntAct25187624 details
TLR3_HUMANSIGL6_HUMANIntAct25187624 details
TLR3_HUMANSIGL7_HUMANIntAct25187624 details
TLR3_HUMANSIGL9_HUMANIntAct25187624 details
TLR3_HUMANSIG10_HUMANIntAct25187624 details
TLR3_HUMANSIG11_HUMANIntAct25187624 details
TLR3_HUMANRN216_HUMANBioGRID, HPRD15107846 details
TLR3_HUMANMYD88_HUMANBioGRID, HPRD12646618 details
TLR3_HUMANMP2K6_HUMANBioGRID12609980 details
TLR3_HUMANTCAM1_HUMANBioGRID, HPRD12539043 14982987 25736436 27810922 31511519 details
TLR3_HUMANDRA_HUMANBioGRID24600555 details
TLR3_HUMANRN170_HUMANBioGRID31076723 details
TLR3_HUMANTCAM2_HUMANHPRD14519765 details
TLR3_HUMANP85A_HUMANBioGRID, MINT15502848 16858407 details
TLR3_HUMANSRC_HUMANMINT16858407 details
TLR3_HUMANTRIL_HUMANIntAct21911501 details
TLR3_HUMANMBL2_HUMANMINT24530528 details
TLR3_HUMANUN93B_HUMANBioGRID, UniProt22164301 31604943 details
TLR3_HUMANIRAK2_HUMANBioGRID17878161 details
TLR3_HUMANTRI69_HUMANBioGRID21911421 details
TLR3_HUMANTBK1_HUMANBioGRID21911421 27810922 details
TLR3_HUMANTRAF6_HUMANBioGRID, HPRD12609980 16115877 21911421 27810922 details
TLR3_HUMANM3K7_HUMANBioGRID12609980 16115877 details
TLR3_HUMANTAB2_HUMANBioGRID12609980 details
TLR3_HUMANRIPK1_HUMANBioGRID16115877 27810922 details
TLR3_HUMANKSYK_HUMANBioGRID23962979 details
TLR3_HUMANWDFY1_HUMANBioGRID25736436 details
TLR3_HUMANIRGM_HUMANBioGRID25891078 details
TLR3_HUMANRNF31_HUMANBioGRID27810922 details
TLR3_HUMANSHRPN_HUMANBioGRID27810922 details
TLR3_HUMANCASP8_HUMANBioGRID27810922 details
TLR3_HUMANFADD_HUMANBioGRID27810922 details
TLR3_HUMANHOIL1_HUMANBioGRID27810922 details
TLR3_HUMANNEMO_HUMANBioGRID27810922 details
TLR3_HUMANBIRC2_HUMANBioGRID27810922 details
TLR3_HUMANBIRC3_HUMANBioGRID27810922 details
TLR3_HUMANKCND2_HUMANBioGRID30758987 details
TLR3_HUMANKCND3_HUMANBioGRID30758987 details
TLR3_HUMANCD14_HUMANHPRD16473828 details
TLR3_HUMANCSK_HUMANHPRD16858407 details