Entity Details

Primary name FMN2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NZ56
EntryNameFMN2_HUMAN
FullNameFormin-2
TaxID9606
Evidenceevidence at protein level
Length1722
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesFMN2

GO terms

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GOName
GO:0003779 actin binding
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0006974 cellular response to DNA damage stimulus
GO:0007275 multicellular organism development
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0030659 cytoplasmic vesicle membrane
GO:0035556 intracellular signal transduction
GO:0040038 polar body extrusion after meiotic divisions
GO:0042177 negative regulation of protein catabolic process
GO:0043066 negative regulation of apoptotic process
GO:0046907 intracellular transport
GO:0048471 perinuclear region of cytoplasm
GO:0048477 oogenesis
GO:0051295 establishment of meiotic spindle localization
GO:0051758 homologous chromosome movement towards spindle pole in meiosis I anaphase
GO:0070649 formin-nucleated actin cable assembly
GO:0071456 cellular response to hypoxia
GO:2000781 positive regulation of double-strand break repair

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Cytoplasmic vesicle membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000591 DEP domainDomainDomain
IPR015425 Formin, FH2 domainDomainDomain
IPR042201 Formin, FH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
616193 OMIMMental retardation, autosomal recessive 47 (MRT47)A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT47 patients show delayed development, with cognition and speech more affected than motor skills. The disease is caused by variants affecting the gene represented in this entry.