Entity Details

Primary name G6PI_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP06744
EntryNameG6PI_HUMAN
FullNameGlucose-6-phosphate isomerase
TaxID9606
Evidenceevidence at protein level
Length558
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesGPI

GO terms

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GOName
GO:0002639 positive regulation of immunoglobulin production
GO:0004347 glucose-6-phosphate isomerase activity
GO:0005125 cytokine activity
GO:0005576 extracellular region
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005975 carbohydrate metabolic process
GO:0006094 gluconeogenesis
GO:0006096 glycolytic process
GO:0006959 humoral immune response
GO:0007599 hemostasis
GO:0008083 growth factor activity
GO:0010595 positive regulation of endothelial cell migration
GO:0016020 membrane
GO:0031625 ubiquitin protein ligase binding
GO:0034774 secretory granule lumen
GO:0043312 neutrophil degranulation
GO:0048029 monosaccharide binding
GO:0051156 glucose 6-phosphate metabolic process
GO:0061621 canonical glycolysis
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

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Subcellular Location
Cytoplasm
Secreted

Domains

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DomainNameCategoryType
IPR001672 Phosphoglucose isomerase (PGI)FamilyFamily
IPR018189 Phosphoglucose isomerase, conserved siteSiteConserved site
IPR023096 Phosphoglucose isomerase, C-terminalFamilyHomologous superfamily
IPR035476 Phosphoglucose isomerase, SIS domain 1DomainDomain
IPR035482 Phosphoglucose isomerase, SIS domain 2DomainDomain

Diseases

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Disease IDSourceNameDescription
613470 OMIMHemolytic anemia, non-spherocytic, due to glucose phosphate isomerase deficiency (HA-GPID)A form of anemia in which there is no abnormal hemoglobin or spherocytosis. It is caused by glucose phosphate isomerase deficiency. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB02007 alpha-D-glucose 6-phosphateDrugbanksmall molecule
DB02076 6-phospho-D-gluconic acidDrugbanksmall molecule
DB02093 5-phospho-D-arabinohydroxamic acidDrugbanksmall molecule
DB02548 D-glucitol 6-phosphateDrugbanksmall molecule
DB03042 5-Phosphoarabinonic AcidDrugbanksmall molecule
DB03581 Glucose-6-PhosphateDrugbanksmall molecule
DB03937 D-erythrose 4-phosphateDrugbanksmall molecule
DB04493 Fructose-6-phosphateDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB11638 ArtenimolDrugbanksmall molecule

Interactions

26 interactions

InteractorPartnerSourcesPublicationsLink
G6PI_HUMANPCNA_HUMANBioGRID20849852 details
G6PI_HUMANAMFR_HUMANBioGRID, HPRD16563432 24810856 details
G6PI_HUMANIF2P_HUMANBioGRID, IntAct27173435 unassigned1312 details
G6PI_HUMANHPRT_HUMANBioGRID, IntAct27173435 unassigned1312 details
G6PI_HUMANPA2G4_HUMANBioGRID, IntAct27173435 unassigned1312 details
G6PI_HUMANCRNN_HUMANBioGRID, IntAct27173435 unassigned1312 details
G6PI_HUMANSIAS_HUMANBioGRID, IntAct27173435 unassigned1312 details
G6PI_HUMANSND1_HUMANBioGRID, IntAct27173435 unassigned1312 details
G6PI_HUMANIPYR_HUMANBioGRID, IntAct27173435 unassigned1312 details
G6PI_HUMANUBE2N_HUMANBioGRID, IntAct27173435 unassigned1312 details
G6PI_HUMANRM12_HUMANBioGRID, IntAct27173435 unassigned1312 details
G6PI_HUMANIDHP_HUMANBioGRID, IntAct27173435 unassigned1312 details
G6PI_HUMANANXA5_HUMANBioGRID, IntAct27173435 unassigned1312 details
G6PI_HUMANRU2B_HUMANBioGRID, IntAct27173435 unassigned1312 details
G6PI_HUMANCISY_HUMANBioGRID, IntAct27173435 unassigned1312 details
G6PI_HUMANCPNE3_HUMANBioGRID, IntAct27173435 unassigned1312 details
G6PI_HUMANZN207_HUMANBioGRID, IntAct27173435 unassigned1312 details
G6PI_HUMANPLST_HUMANBioGRID, IntAct27173435 unassigned1312 details
G6PI_HUMANPDIA3_HUMANBioGRID, IntAct27173435 unassigned1312 details
G6PI_HUMANTRAP1_HUMANBioGRID, IntAct27173435 unassigned1312 details
G6PI_HUMANPAR14_HUMANBioGRID, HPRD17875708 details
G6PI_HUMANISG15_HUMANBioGRID16009940 33024031 details
G6PI_HUMANU2AF2_HUMANBioGRID26641092 details
G6PI_HUMANCSK21_HUMANHPRD11004567 details
G6PI_HUMANIBP3_HUMANHPRD15059907 details
G6PI_HUMANG6PI_HUMANHPRD15637053 details