Entity Details

Primary name PRLR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP16471
EntryNamePRLR_HUMAN
FullNameProlactin receptor
TaxID9606
Evidenceevidence at protein level
Length622
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesPRLR

GO terms

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GOName
GO:0004896 cytokine receptor activity
GO:0004923 leukemia inhibitory factor receptor activity
GO:0004925 prolactin receptor activity
GO:0005127 ciliary neurotrophic factor receptor binding
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0006694 steroid biosynthetic process
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity
GO:0007566 embryo implantation
GO:0007595 lactation
GO:0008284 positive regulation of cell population proliferation
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0017046 peptide hormone binding
GO:0019221 cytokine-mediated signaling pathway
GO:0019955 cytokine binding
GO:0031904 endosome lumen
GO:0038165 oncostatin-M-mediated signaling pathway
GO:0042976 activation of Janus kinase activity
GO:0043066 negative regulation of apoptotic process
GO:0043235 receptor complex
GO:0046872 metal ion binding
GO:0060397 growth hormone receptor signaling pathway via JAK-STAT
GO:0120162 positive regulation of cold-induced thermogenesis

Subcellular Location

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Subcellular Location
Membrane
Secreted

Domains

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DomainNameCategoryType
IPR003528 Long hematopoietin receptor, single chain, conserved siteSiteConserved site
IPR003961 Fibronectin type IIIDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015152 Growth hormone/erythropoietin receptor, ligand bindingDomainDomain
IPR033230 Prolactin receptorFamilyFamily
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
615555 OMIMHyperprolactinemia (HPRL)A disorder characterized by increased levels of prolactin in the blood not associated with gestation or the puerperium. HPRL may result in infertility, hypogonadism, and galactorrhea. The disease is caused by variants affecting the gene represented in this entry.
615554 OMIMMultiple fibroadenomas of the breast (MFAB)A benign breast disease marked by lobuloalveolar growth with abnormally high proliferation of the epithelium, and characterized by the presence of more than 3 fibroadenomas in one breast. Fibroadenomas are adenomas containing fibrous tissue. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00052 SomatotropinDrugbankbiotech