Entity Details

Primary name TNAP3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP21580
EntryNameTNAP3_HUMAN
FullNameTumor necrosis factor alpha-induced protein 3
TaxID9606
Evidenceevidence at protein level
Length790
SequenceStatuscomplete
DateCreated1991-05-01
DateModified2021-06-02

Ontological Relatives

GenesTNFAIP3

GO terms

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GOName
GO:0001922 B-1 B cell homeostasis
GO:0002020 protease binding
GO:0002237 response to molecule of bacterial origin
GO:0002634 regulation of germinal center formation
GO:0002677 negative regulation of chronic inflammatory response
GO:0003677 DNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0004843 thiol-dependent deubiquitinase
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0007010 cytoskeleton organization
GO:0008022 protein C-terminus binding
GO:0008270 zinc ion binding
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0016477 cell migration
GO:0016579 protein deubiquitination
GO:0019900 kinase binding
GO:0030177 positive regulation of Wnt signaling pathway
GO:0031397 negative regulation of protein ubiquitination
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032480 negative regulation of type I interferon production
GO:0032495 response to muramyl dipeptide
GO:0032691 negative regulation of interleukin-1 beta production
GO:0032703 negative regulation of interleukin-2 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0034136 negative regulation of toll-like receptor 2 signaling pathway
GO:0034140 negative regulation of toll-like receptor 3 signaling pathway
GO:0034144 negative regulation of toll-like receptor 4 signaling pathway
GO:0034148 negative regulation of toll-like receptor 5 signaling pathway
GO:0035523 protein K29-linked deubiquitination
GO:0035871 protein K11-linked deubiquitination
GO:0042802 identical protein binding
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043130 ubiquitin binding
GO:0043621 protein self-association
GO:0045732 positive regulation of protein catabolic process
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045779 negative regulation of bone resorption
GO:0045824 negative regulation of innate immune response
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050691 regulation of defense response to virus by host
GO:0050728 negative regulation of inflammatory response
GO:0050869 negative regulation of B cell activation
GO:0061043 regulation of vascular wound healing
GO:0061578 Lys63-specific deubiquitinase activity
GO:0070062 extracellular exosome
GO:0070301 cellular response to hydrogen peroxide
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0070429 negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070433 negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0070530 K63-linked polyubiquitin modification-dependent protein binding
GO:0070536 protein K63-linked deubiquitination
GO:0070936 protein K48-linked ubiquitination
GO:0071108 protein K48-linked deubiquitination
GO:0071222 cellular response to lipopolysaccharide
GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0072573 tolerance induction to lipopolysaccharide
GO:0072666 establishment of protein localization to vacuole
GO:0090291 negative regulation of osteoclast proliferation
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1903364 positive regulation of cellular protein catabolic process
GO:1990168 protein K33-linked deubiquitination
GO:2000347 positive regulation of hepatocyte proliferation
GO:2000349 negative regulation of CD40 signaling pathway
GO:2000352 negative regulation of endothelial cell apoptotic process

Subcellular Location

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Subcellular Location
Cytoplasm
Lysosome
Nucleus

Domains

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DomainNameCategoryType
IPR002653 Zinc finger, A20-typeDomainDomain
IPR003323 OTU domainDomainDomain
IPR033478 A20 peptidaseFamilyFamily

Diseases

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Disease IDSourceNameDescription
616744 OMIMAutoinflammatory syndrome, familial, Behcet-like (AISBL)An autosomal dominant, autoinflammatory disorder with early onset, characterized by ulceration of mucosal surfaces, particularly in the oral and genital areas. Additional variable features include skin rash, uveitis, and polyarthritis. The disease is caused by variants affecting the gene represented in this entry.

Interactions

90 interactions

InteractorPartnerSourcesPublicationsLink
TNAP3_HUMANNEMO_HUMANBioGRID, HPRD, IntAct, MINT10755617 11389905 21988832 22099304 23032186 26802121 30561431 31585000 details
TNAP3_HUMANTNAP3_HUMANBioGRID, HPRD, IntAct, MINT11389905 15258597 24008839 25165885 25416956 25502805 28244869 30561431 31515488 32296183 8692885 8797804 details
TNAP3_HUMANTNIP1_HUMANBioGRID, HPRD, IntAct, MINT10385526 11389905 12586352 12965196 18029035 21988832 25165885 25416956 30561431 31515488 32296183 details
TNAP3_HUMANTNIP2_HUMANBioGRID, HPRD, IntAct, MINT10385526 11389905 11390377 15169888 18029035 21266526 30561431 details
TNAP3_HUMANTAXB1_HUMANBioGRID, HPRD, IntAct, MINT10435631 11389905 23018911 28514442 30561431 32296183 details
TNAP3_HUMANTRAF6_HUMANBioGRID, HPRD, IntAct11463333 15334086 18164316 20622874 21220427 23018911 23105109 23737552 28244869 29720226 31625129 32015333 9928991 details
TNAP3_HUMANRNF11_HUMANBioGRID, HPRD, MINT15231748 19131965 22507528 23018911 details
TNAP3_HUMANLAPM5_HUMANBioGRID, HPRD, MINT15231748 22733818 details
TNAP3_HUMANUBC_HUMANBioGRID, MINT14748687 15334086 18029035 19285159 19373254 20622874 21095585 22099304 23032186 23032187 23827681 27732584 details
TNAP3_HUMAN1433G_HUMANBioGRID, HPRD, IntAct20936779 8702721 details
TNAP3_HUMAN1433E_HUMANBioGRID, HPRD, IntAct21988832 8702721 details
TNAP3_HUMAN1433Z_HUMANBioGRID, HPRD, IntAct20936779 21988832 8702721 9299557 details
TNAP3_HUMANGIT2_HUMANBioGRID, IntAct21988832 details
TNAP3_HUMANTNFA_HUMANBioGRID, IntAct, MINT22099304 23032186 23032187 25911380 26670046 27307491 27545878 30561431 details
TNAP3_HUMANHOIL1_HUMANBioGRID, MINT23032186 23105109 details
TNAP3_HUMANTRI23_HUMANBioGRID, IntAct25416956 32296183 details
TNAP3_HUMANTRAF2_HUMANBioGRID, HPRD, IntAct10544141 24008839 25416956 30561431 31515488 32296183 8692885 details
TNAP3_HUMANARRD3_HUMANBioGRID, IntAct25416956 32296183 details
TNAP3_HUMANTNIP3_HUMANBioGRID, IntAct17088249 25416956 details
TNAP3_HUMANLNX1_HUMANBioGRID, IntAct32296183 details
TNAP3_HUMANDRC4_HUMANBioGRID, IntAct32296183 details
TNAP3_HUMANRD23A_HUMANBioGRID, IntAct32296183 details
TNAP3_HUMANRN216_HUMANBioGRID, IntAct32296183 details
TNAP3_HUMANRN114_HUMANBioGRID, IntAct25165885 28514442 details
TNAP3_HUMANCASP8_HUMANBioGRID, DIP19060883 26437781 28574503 details
TNAP3_HUMANIKKB_HUMANBioGRID, DIP, HPRD11594795 21220427 26649818 details
TNAP3_HUMANRIPK1_HUMANBioGRID, HPRD, IntAct15258597 18246070 19131965 22585859 29274253 30561431 32015333 details
TNAP3_HUMANTRAF1_HUMANBioGRID, HPRD25996949 8692885 9928991 details
TNAP3_HUMAN1433F_HUMANBioGRID, HPRD19615732 8702721 9299557 details
TNAP3_HUMAN1433B_HUMANBioGRID, HPRD18029035 19615732 8702721 details
TNAP3_HUMANM3K5_HUMANBioGRID20448643 29227477 details
TNAP3_HUMANCCD50_HUMANBioGRID, HPRD18029035 details
TNAP3_HUMANUBE2N_HUMANBioGRID15258597 details
TNAP3_HUMANTRIM2_HUMANBioGRID23105109 details
TNAP3_HUMANRNF5_HUMANBioGRID23105109 details
TNAP3_HUMANRNF14_HUMANBioGRID23105109 details
TNAP3_HUMANRNF12_HUMANBioGRID23105109 details
TNAP3_HUMANTRIM3_HUMANBioGRID23105109 details
TNAP3_HUMANTRIM8_HUMANBioGRID23105109 details
TNAP3_HUMANTRIM5_HUMANBioGRID23105109 details
TNAP3_HUMANOCLN_HUMANBioGRID22031828 details
TNAP3_HUMAN1433T_HUMANBioGRID25165885 details
TNAP3_HUMANUB2D1_HUMANBioGRID15258597 28892081 details
TNAP3_HUMANSNAI1_HUMANBioGRID28892081 details
TNAP3_HUMANDPTOR_HUMANBioGRID29940800 details
TNAP3_HUMANRN168_HUMANBioGRID29233925 details
TNAP3_HUMANPIBF1_HUMANBioGRID32296183 details
TNAP3_HUMANGSK3B_HUMANBioGRID31471107 details
TNAP3_HUMANCEBPB_HUMANBioGRID31471107 details
TNAP3_HUMANPFKAL_HUMANBioGRID32015333 details
TNAP3_HUMANTCAM1_HUMANBioGRID, HPRD, MINT15474016 details
TNAP3_HUMANKRR1_HUMANMINT19131965 details
TNAP3_HUMANWNK1_HUMANIntAct20936779 details
TNAP3_HUMANHS90B_HUMANIntAct22939624 details
TNAP3_HUMANRNF31_HUMANBioGRID, IntAct, MINT23032186 23032187 27545878 30561431 details
TNAP3_HUMANFADD_HUMANBioGRID, IntAct20448643 26437781 30561431 details
TNAP3_HUMANTBK1_HUMANBioGRID, IntAct15661910 19615732 21885437 30561431 details
TNAP3_HUMANBIRC2_HUMANBioGRID, IntAct24008839 30561431 32015333 details
TNAP3_HUMANTNR1A_HUMANBioGRID, IntAct20448643 24098568 26802121 30420664 30561431 31406107 details
TNAP3_HUMANIKKA_HUMANBioGRID, HPRD11594795 details
TNAP3_HUMANLAMP1_HUMANBioGRID18329387 details
TNAP3_HUMANPLAT4_HUMANBioGRID16306043 details
TNAP3_HUMANBECN1_HUMANBioGRID20501938 details
TNAP3_HUMANIRAK1_HUMANBioGRID21220427 details
TNAP3_HUMANIRAK2_HUMANBioGRID21220427 details
TNAP3_HUMANIRF7_HUMANBioGRID20392859 details
TNAP3_HUMANIKKE_HUMANBioGRID15661910 21885437 details
TNAP3_HUMANTNF10_HUMANBioGRID22585859 details
TNAP3_HUMANTR10B_HUMANBioGRID22585859 details
TNAP3_HUMANHS90A_HUMANBioGRID22939624 details
TNAP3_HUMANP53_HUMANBioGRID23471665 24099634 details
TNAP3_HUMANAXIN1_HUMANBioGRID23671587 details
TNAP3_HUMANNFKB2_HUMANBioGRID24008839 details
TNAP3_HUMANBIRC3_HUMANBioGRID24008839 details
TNAP3_HUMANMALT1_HUMANBioGRID24491438 details
TNAP3_HUMANMTOR_HUMANBioGRID26043155 29940800 details
TNAP3_HUMANNOD2_HUMANBioGRID26670046 details
TNAP3_HUMANNFKB1_HUMANBioGRID28923245 details
TNAP3_HUMANCUL3_HUMANBioGRID28574503 details
TNAP3_HUMANSQSTM_HUMANBioGRID28574503 details
TNAP3_HUMANPRGC1_HUMANBioGRID29678181 details
TNAP3_HUMANTLR9_HUMANBioGRID30277474 details
TNAP3_HUMANSMAD6_HUMANBioGRID29720226 details
TNAP3_HUMANPELI1_HUMANBioGRID29720226 details
TNAP3_HUMANTR10A_HUMANBioGRID29274253 details
TNAP3_HUMANCTNB1_HUMANBioGRID30323974 details
TNAP3_HUMANGRN_HUMANBioGRID31585000 details
TNAP3_HUMANSTAT3_HUMANBioGRID31958753 details
TNAP3_HUMANACSL4_HUMANBioGRID31160087 details
TNAP3_HUMANZFAN5_HUMANHPRD14754897 details