Entity Details

Primary name SYVC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP26640
EntryNameSYVC_HUMAN
FullNameValine--tRNA ligase
TaxID9606
Evidenceevidence at protein level
Length1264
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesVARS1

GO terms

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GOName
GO:0002161 aminoacyl-tRNA editing activity
GO:0004832 valine-tRNA ligase activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0006418 tRNA aminoacylation for protein translation
GO:0006438 valyl-tRNA aminoacylation

Subcellular Location

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Domains

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DomainNameCategoryType
IPR001412 Aminoacyl-tRNA synthetase, class I, conserved siteSiteConserved site
IPR002300 Aminoacyl-tRNA synthetase, class IaDomainDomain
IPR002303 Valine-tRNA ligaseFamilyFamily
IPR004046 Glutathione S-transferase, C-terminalDomainDomain
IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domainFamilyHomologous superfamily
IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-bindingFamilyHomologous superfamily
IPR010987 Glutathione S-transferase, C-terminal-likeDomainDomain
IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-bindingDomainDomain
IPR014729 Rossmann-like alpha/beta/alpha sandwich foldFamilyHomologous superfamily
IPR033705 Valyl tRNA synthetase, anticodon-binding domainDomainDomain
IPR036282 Glutathione S-transferase, C-terminal domain superfamilyFamilyHomologous superfamily
IPR037118 Valyl-tRNA synthetase, tRNA-binding arm superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
617802 OMIMNeurodevelopmental disorder with microcephaly, seizures, and cortical atrophy (NDMSCA)An autosomal recessive neurodevelopmental disorder characterized by severe developmental delay, intellectual disability, severe microcephaly, and cortical atrophy. The disease may be caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00161 ValineDrugbanksmall molecule