Entity Details

Primary name IL3RB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP32927
EntryNameIL3RB_HUMAN
FullNameCytokine receptor common subunit beta
TaxID9606
Evidenceevidence at protein level
Length897
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesCSF2RB

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0004896 cytokine receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007165 signal transduction
GO:0007585 respiratory gaseous exchange by respiratory system
GO:0019221 cytokine-mediated signaling pathway
GO:0030526 granulocyte macrophage colony-stimulating factor receptor complex
GO:0032496 response to lipopolysaccharide
GO:0036016 cellular response to interleukin-3
GO:0038023 signaling receptor activity
GO:0038043 interleukin-5-mediated signaling pathway
GO:0038156 interleukin-3-mediated signaling pathway
GO:0044267 cellular protein metabolic process

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR003531 Short hematopoietin receptor, family 1, conserved siteSiteConserved site
IPR003961 Fibronectin type IIIDomainDomain
IPR011365 Cytokine IL-3/IL-5/GM-CSF receptor common beta chainFamilyFamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015373 Interferon/interleukin receptor domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
614370 OMIMPulmonary surfactant metabolism dysfunction 5 (SMDP5)A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00020 SargramostimDrugbankbiotech
DB05264 NPI 32101Drugbanksmall molecule
DB05943 ResatorvidDrugbanksmall molecule

Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
IL3RB_HUMANJAK2_HUMANBioGRID, HPRD, IntAct, MINT10772872 16437163 18692472 21965659 7527392 7775438 details
IL3RB_HUMANIL3_HUMANBioGRID, HPRD, IntAct18692472 8649415 9278420 details
IL3RB_HUMAN1433Z_HUMANBioGRID, HPRD, MINT10477722 8278375 details
IL3RB_HUMANPTN6_HUMANBioGRID, HPRD, MINT7528537 8246974 9162089 9254654 details
IL3RB_HUMANPTN11_HUMANBioGRID, HPRD, MINT15194700 9162089 9254654 9973406 details
IL3RB_HUMANITB1_HUMANI2D20802515 details
IL3RB_HUMANPK3CA_HUMANDIP23526884 details
IL3RB_HUMANRACK1_HUMANBioGRID, HPRD10490850 details
IL3RB_HUMANLYN_HUMANBioGRID, HPRD7636265 9973406 details
IL3RB_HUMANMD2L1_HUMANBioGRID, HPRD11551900 details
IL3RB_HUMANIKKB_HUMANBioGRID12637324 details
IL3RB_HUMANSHC1_HUMANBioGRID, HPRD, MINT10477722 10704825 15194700 16437163 details
IL3RB_HUMANCSF2_HUMANHPRD, IntAct18692472 2645577 8278375 details
IL3RB_HUMANIL5_HUMANIntAct1495999 details
IL3RB_HUMANIL5RA_HUMANBioGRID, HPRD, IntAct1495999 9516124 details
IL3RB_HUMANJAK1_HUMANBioGRID, HPRD, IntAct11557047 15194700 21965659 9516124 details
IL3RB_HUMANIL3RB_HUMANBioGRID, HPRD10753826 11207369 8666948 details
IL3RB_HUMANKPCB_HUMANBioGRID, HPRD10490850 details
IL3RB_HUMANSOCS1_HUMANBioGRID24086733 29991678 details
IL3RB_HUMANVGFR2_HUMANBioGRID, HPRD16007196 details
IL3RB_HUMANSTAT3_HUMANBioGRID, HPRD15194700 8631962 details
IL3RB_HUMANSTAT1_HUMANHPRD8631962 details
IL3RB_HUMANFES_HUMANHPRD8631962 details
IL3RB_HUMANKIT_HUMANHPRD15308671 details
IL3RB_HUMANKSYK_HUMANHPRD8666899 details
IL3RB_HUMANFYN_HUMANHPRD9195918 details
IL3RB_HUMANHCK_HUMANHPRD9195918 details
IL3RB_HUMANLCK_HUMANHPRD1638019 7896837 details
IL3RB_HUMANIL3RA_HUMANHPRD8649415 details
IL3RB_HUMANCISH_HUMANHPRD7796808 details
IL3RB_HUMANEPOR_HUMANHPRD12488507 details
IL3RB_HUMANCSF2R_HUMANHPRD9211889 details