Entity Details

Primary name ITA8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP53708
EntryNameITA8_HUMAN
FullNameIntegrin alpha-8
TaxID9606
Evidenceevidence at protein level
Length1063
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesITGA8

GO terms

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GOName
GO:0001822 kidney development
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007420 brain development
GO:0008305 integrin complex
GO:0009986 cell surface
GO:0014069 postsynaptic density
GO:0030198 extracellular matrix organization
GO:0032591 dendritic spine membrane
GO:0034446 substrate adhesion-dependent cell spreading
GO:0034678 integrin alpha8-beta1 complex
GO:0043204 perikaryon
GO:0046872 metal ion binding
GO:0048333 mesodermal cell differentiation
GO:0098609 cell-cell adhesion

Subcellular Location

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Subcellular Location
Cell membrane
Membrane

Domains

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DomainNameCategoryType
IPR000413 Integrin alpha chainFamilyFamily
IPR013517 FG-GAP repeatRepeatRepeat
IPR013519 Integrin alpha beta-propellorRepeatRepeat
IPR013649 Integrin alpha-2DomainDomain
IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved siteSiteConserved site
IPR028994 Integrin alpha, N-terminalFamilyHomologous superfamily
IPR032695 Integrin domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
191830 OMIMRenal hypodysplasia/aplasia 1 (RHDA1)A perinatally lethal renal disease encompassing a spectrum of kidney development defects, including renal agenesis, bilateral renal aplasia, hypoplasia, (cystic) dysplasia, and severe obstructive uropathy. The disease is caused by variants affecting the gene represented in this entry.

Interactions

4 interactions