Entity Details

Primary name B2MG_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP61769
EntryNameB2MG_HUMAN
FullNameBeta-2-microglobulin
TaxID9606
Evidenceevidence at protein level
Length119
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesB2M

GO terms

Show/Hide Table
GOName
GO:0006826 iron ion transport
GO:1904437 positive regulation of transferrin receptor binding
GO:2000774 positive regulation of cellular senescence
GO:0000139 Golgi membrane
GO:0007611 learning or memory
GO:0046686 response to cadmium ion
GO:1900121 negative regulation of receptor binding
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0031901 early endosome membrane
GO:0030670 phagocytic vesicle membrane
GO:0042803 protein homodimerization activity
GO:0042824 MHC class I peptide loading complex
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0005788 endoplasmic reticulum lumen
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0019731 antibacterial humoral response
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050776 regulation of immune response
GO:1904434 positive regulation of ferrous iron binding
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0031905 early endosome lumen
GO:0032092 positive regulation of protein binding
GO:0042612 MHC class I protein complex
GO:0043312 neutrophil degranulation
GO:0002237 response to molecule of bacterial origin
GO:0005794 Golgi apparatus
GO:0050690 regulation of defense response to virus by virus
GO:0055072 iron ion homeostasis
GO:0071222 cellular response to lipopolysaccharide
GO:1990712 HFE-transferrin receptor complex
GO:0003254 regulation of membrane depolarization
GO:0071316 cellular response to nicotine
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0045646 regulation of erythrocyte differentiation
GO:0051289 protein homotetramerization
GO:0002481 antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
GO:0035580 specific granule lumen
GO:0090647 modulation of age-related behavioral decline
GO:1990000 amyloid fibril formation
GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0071283 cellular response to iron(III) ion
GO:1904724 tertiary granule lumen
GO:0042026 protein refolding
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:2000978 negative regulation of forebrain neuron differentiation
GO:0010977 negative regulation of neuron projection development
GO:0050829 defense response to Gram-negative bacterium
GO:0070062 extracellular exosome
GO:0001895 retina homeostasis
GO:0012507 ER to Golgi transport vesicle membrane
GO:0033077 T cell differentiation in thymus
GO:0050768 negative regulation of neurogenesis
GO:0005829 cytosol
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0002726 positive regulation of T cell cytokine production
GO:0005576 extracellular region
GO:0009897 external side of plasma membrane
GO:0050830 defense response to Gram-positive bacterium
GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:0045087 innate immune response
GO:0052031 modulation by symbiont of host defense response
GO:0016020 membrane
GO:0034756 regulation of iron ion transport
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0071281 cellular response to iron ion
GO:1900122 positive regulation of receptor binding
GO:0005925 focal adhesion
GO:0055038 recycling endosome membrane

Subcellular Location

Show/Hide Table
Subcellular Location
Cell surface
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR003006 Immunoglobulin/major histocompatibility complex, conserved siteSiteConserved site
IPR003597 Immunoglobulin C1-setDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015707 Beta-2-MicroglobulinFamilyFamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
105200 OMIMAmyloidosis 8 (AMYL8)A form of hereditary generalized amyloidosis. Clinical features include extensive visceral amyloid deposits, renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. There is no involvement of the nervous system. The disease is caused by variants affecting the gene represented in this entry. Apart from the presence of causative mutations, beta-2-microglobulin may adopt the fibrillar configuration of amyloid when its serum levels are persistently high. High beta(2)-microglobulin serum levels result in amyloidosis in patients on long-term hemodialysis (PubMed:7918443). In contrast to patients with dialysis-related amyloidosis, patients with hereditary amyloidosis have normal circulating concentrations of beta2-microglobulin (PubMed:22693999).
241600 OMIMImmunodeficiency 43 (IMD43)A disorder characterized by marked reduction in serum concentrations of immunoglobulins and albumin, and hypoproteinemia due to hypercatabolism. Patients may suffer from recurrent respiratory tract infections and severe skin disease. The disease is caused by variants affecting the gene represented in this entry.

Drugs

Show/Hide Table
DrugNameSourceType
DB02740 3-Indolebutyric AcidDrugbanksmall molecule
DB04464 N-FormylmethionineDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB11130 OpiumDrugbanksmall molecule

Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
B2MG_HUMANCD1B_HUMANBioGRID, HPRD, IntAct, MINT12118248 14764708 26186194 28514442 details
B2MG_HUMANHLAC_HUMANBioGRID, HPRD, IntAct, MINT10429675 2450918 26186194 27649529 28514442 28546555 details
B2MG_HUMANFCGRN_HUMANBioGRID, HPRD, IntAct, MINT10933786 12006623 28514442 31289263 details
B2MG_HUMANHLAB_HUMANBioGRID, HPRD, IntAct, MINT10975842 11738047 11823531 12244049 17057332 2450918 26186194 27649529 28514442 8624811 8624812 details
B2MG_HUMANHLAA_HUMANBioGRID, HPRD, IntAct, MINT11502003 1448153 20831383 20844028 24163410 26439010 27649529 8805302 93026 details
B2MG_HUMANBAG6_HUMANBioGRID, HPRD, IntAct16169070 details
B2MG_HUMANPRS23_HUMANBioGRID, HPRD, IntAct16169070 details
B2MG_HUMANCD1A_HUMANHPRD, IntAct12833155 15723809 details
B2MG_HUMANGRB2_HUMANBioGRID, IntAct18624398 details
B2MG_HUMANB2MG_HUMANBioGRID, DIP, HPRD, MINT12023961 17108084 18543331 18579777 19172750 19564620 20826442 21131979 21220305 21569201 22289140 22575645 23645685 details
B2MG_HUMANPCOC1_HUMANmatrixdb24117177 details
B2MG_HUMANPCNA_HUMANIntAct, UniProt23527218 26030842 details
B2MG_HUMANHSPB2_HUMANbhf-ucl, BioGRID26465331 details
B2MG_HUMANCD1D_HUMANBioGRID, DIP, HPRD10221650 11257307 17581592 details
B2MG_HUMANHMR1_HUMANDIP23051753 details
B2MG_HUMANACM4_HUMANBioGRID, MINT28298427 details
B2MG_HUMANP63_HUMANIntAct12692135 details
B2MG_HUMANPYGO1_HUMANIntAct32814053 details
B2MG_HUMANA2MG_HUMANBioGRID, HPRD10731476 details
B2MG_HUMANCRYAB_HUMANBioGRID23645685 details
B2MG_HUMANCXCR4_HUMANBioGRID18083706 details
B2MG_HUMANHFE_HUMANBioGRID, DIP, HPRD, MINT, UniProt10638746 10791995 15965644 20618438 details
B2MG_HUMANCALR_HUMANBioGRID, HPRD, IntAct25241761 8769474 details
B2MG_HUMANCD244_HUMANIntAct20164429 details
B2MG_HUMANHLAF_HUMANBioGRID, HPRD, IntAct11169396 20483783 26186194 27649529 details
B2MG_HUMANLIRB1_HUMANHPRD, IntAct12897781 27649529 details
B2MG_HUMANCD1E_HUMANBioGRID, HPRD, IntAct10948205 28514442 details
B2MG_HUMANHLAG_HUMANDIP, HPRD, IntAct17056715 18332182 9228302 details
B2MG_HUMANHLAE_HUMANBioGRID, HPRD, IntAct10064069 18332182 9605335 details
B2MG_HUMANTPSN_HUMANBioGRID17055437 details
B2MG_HUMANTAP2_HUMANBioGRID8805302 details
B2MG_HUMANCD8A_HUMANHPRD11914379 details