Entity Details

Primary name NSUN2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ08J23
EntryNameNSUN2_HUMAN
FullNameRNA cytosine C(5)-methyltransferase NSUN2
TaxID9606
Evidenceevidence at protein level
Length767
SequenceStatuscomplete
DateCreated2007-05-29
DateModified2021-06-02

Ontological Relatives

GenesNSUN2

GO terms

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GOName
GO:0000049 tRNA binding
GO:0001510 RNA methylation
GO:0001701 in utero embryonic development
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005819 spindle
GO:0006400 tRNA modification
GO:0007286 spermatid development
GO:0008168 methyltransferase activity
GO:0010793 regulation of mRNA export from nucleus
GO:0016428 tRNA (cytosine-5-)-methyltransferase activity
GO:0030488 tRNA methylation
GO:0033313 meiotic cell cycle checkpoint signaling
GO:0033391 chromatoid body
GO:0036416 tRNA stabilization
GO:0048820 hair follicle maturation
GO:0051301 cell division
GO:0062152 mRNA (cytidine-5-)-methyltransferase activity
GO:0070062 extracellular exosome
GO:0080009 mRNA methylation
GO:2000736 regulation of stem cell differentiation

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR001678 SAM-dependent methyltransferase RsmB/NOP2-typeDomainDomain
IPR023267 RNA (C5-cytosine) methyltransferaseFamilyFamily
IPR023270 tRNA (C5-cytosine) methyltransferase, NCL1FamilyFamily
IPR029063 S-adenosyl-L-methionine-dependent methyltransferaseFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
611091 OMIMMental retardation, autosomal recessive 5 (MRT5)A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. The disease is caused by variants affecting the gene represented in this entry.