Entity Details

Primary name MARK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ7KZI7
EntryNameMARK2_HUMAN
FullNameSerine/threonine-protein kinase MARK2
TaxID9606
Evidenceevidence at protein level
Length788
SequenceStatuscomplete
DateCreated2005-04-12
DateModified2021-06-02

Ontological Relatives

GenesMARK2

GO terms

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GOName
GO:0000226 microtubule cytoskeleton organization
GO:0000287 magnesium ion binding
GO:0000422 autophagy of mitochondrion
GO:0001764 neuron migration
GO:0003723 RNA binding
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0008289 lipid binding
GO:0010976 positive regulation of neuron projection development
GO:0016020 membrane
GO:0016055 Wnt signaling pathway
GO:0016328 lateral plasma membrane
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0030010 establishment of cell polarity
GO:0030295 protein kinase activator activity
GO:0030425 dendrite
GO:0032147 activation of protein kinase activity
GO:0035556 intracellular signal transduction
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
GO:0045296 cadherin binding
GO:0046777 protein autophosphorylation
GO:0048156 tau protein binding
GO:0050321 tau-protein kinase activity
GO:0050770 regulation of axonogenesis
GO:0051493 regulation of cytoskeleton organization
GO:0051646 mitochondrion localization
GO:0061564 axon development
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0071963 establishment or maintenance of cell polarity regulating cell shape
GO:0097427 microtubule bundle
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1904526 regulation of microtubule binding

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm
Lateral cell membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001772 Kinase associated domain 1 (KA1)DomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR015940 Ubiquitin-associated domainDomainDomain
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR028375 KA1 domain/Ssp2, C-terminalFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

52 interactions

InteractorPartnerSourcesPublicationsLink
MARK2_HUMAN1433Z_HUMANBioGRID, HPRD, IntAct, MINT11257119 14676191 15161933 15324659 16306228 28514442 details
MARK2_HUMANARHG2_HUMANBioGRID, IntAct19615732 21513698 22072711 29089450 details
MARK2_HUMANKI13B_HUMANBioGRID, IntAct19615732 20194617 details
MARK2_HUMANMTCL1_HUMANBioGRID, IntAct19615732 20360068 23902687 26496610 details
MARK2_HUMANUTRN_HUMANBioGRID, IntAct19615732 19945424 details
MARK2_HUMANTAU_HUMANBioGRID, IntAct, UniProt23001711 23666762 24251416 26269332 details
MARK2_HUMAN1433T_HUMANBioGRID, IntAct15161933 17353931 19011111 19553522 28514442 details
MARK2_HUMANPTPRD_HUMANBioGRID, MINT22305495 details
MARK2_HUMANKPCD1_HUMANDIP19011111 details
MARK2_HUMANTAOK1_HUMANDIP19966800 details
MARK2_HUMANHDAC7_HUMANBioGRID16980613 details
MARK2_HUMANNEDD4_HUMANBioGRID19953087 details
MARK2_HUMANNED4L_HUMANBioGRID19953087 details
MARK2_HUMANSTK11_HUMANBioGRID, HPRD14976552 16396636 details
MARK2_HUMANRFIP2_HUMANBioGRID16775013 details
MARK2_HUMANPINK1_HUMANBioGRID22238344 details
MARK2_HUMANKPCE_HUMANBioGRID19011111 details
MARK2_HUMANPKD1_HUMANBioGRID19011111 details
MARK2_HUMANGAB1_HUMANBioGRID22883624 details
MARK2_HUMANRNF41_HUMANBioGRID24259665 details
MARK2_HUMANKCC1A_HUMANBioGRID17442826 details
MARK2_HUMANBAIP2_HUMANBioGRID24165937 details
MARK2_HUMANSMUF1_HUMANBioGRID20804422 details
MARK2_HUMANFBX7_HUMANBioGRID27503909 details
MARK2_HUMANCSKP_HUMANBioGRID30217970 details
MARK2_HUMANRFA2_HUMANBioGRID30217970 details
MARK2_HUMANKIFA3_HUMANBioGRID30217970 details
MARK2_HUMANPAR3L_HUMANBioGRID30217970 details
MARK2_HUMANCD44_HUMANBioGRID31080060 details
MARK2_HUMANSTK4_HUMANBioGRID31080060 details
MARK2_HUMANSTK3_HUMANBioGRID31080060 details
MARK2_HUMAN1433F_HUMANBioGRID, IntAct, MINT14676191 16959763 17979178 19553522 19615732 28514442 details
MARK2_HUMAN1433S_HUMANBioGRID, MINT15778465 details
MARK2_HUMAN1433E_HUMANBioGRID, IntAct16306228 16968750 17979178 details
MARK2_HUMANUBP21_HUMANBioGRID, IntAct19615732 22298430 details
MARK2_HUMANKPCI_HUMANBioGRID, IntAct15324659 19615732 details
MARK2_HUMANMARK2_HUMANBioGRID, IntAct16472737 20360068 details
MARK2_HUMAN1433G_HUMANBioGRID, IntAct15324659 16959763 17353931 28514442 details
MARK2_HUMAN1433B_HUMANBioGRID, HPRD, IntAct15324659 16959763 24255178 28514442 details
MARK2_HUMANCBY1_HUMANBioGRID, IntAct27173435 unassigned1312 details
MARK2_HUMANAKT1_HUMANBioGRID18292230 details
MARK2_HUMANAAPK1_HUMANBioGRID16306228 details
MARK2_HUMANPAR6A_HUMANBioGRID, HPRD14676191 details
MARK2_HUMANPTPA_HUMANBioGRID15324659 details
MARK2_HUMANDMD_HUMANBioGRID19945424 details
MARK2_HUMANRHOA_HUMANBioGRID22072711 details
MARK2_HUMANGAB2_HUMANBioGRID22883624 details
MARK2_HUMANPARD3_HUMANBioGRID22883624 34079125 details
MARK2_HUMANRASH_HUMANBioGRID30442766 30639242 details
MARK2_HUMANGRRE1_HUMANBioGRID29395067 details
MARK2_HUMANGSK3B_HUMANHPRD16257959 details
MARK2_HUMANDVL3_HUMANHPRD11433294 details