Entity Details

Primary name STING_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ86WV6
EntryNameSTING_HUMAN
FullNameStimulator of interferon genes protein
TaxID9606
Evidenceevidence at protein level
Length379
SequenceStatuscomplete
DateCreated2007-01-09
DateModified2021-06-02

Ontological Relatives

GenesSTING1

GO terms

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GOName
GO:0000045 autophagosome assembly
GO:0000421 autophagosome membrane
GO:0002218 activation of innate immune response
GO:0002230 positive regulation of defense response to virus by host
GO:0005654 nucleoplasm
GO:0005741 mitochondrial outer membrane
GO:0005768 endosome
GO:0005776 autophagosome
GO:0005777 peroxisome
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0008134 transcription factor binding
GO:0016032 viral process
GO:0016239 positive regulation of macroautophagy
GO:0019901 protein kinase binding
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0030667 secretory granule membrane
GO:0031625 ubiquitin protein ligase binding
GO:0032092 positive regulation of protein binding
GO:0032479 regulation of type I interferon production
GO:0032481 positive regulation of type I interferon production
GO:0032728 positive regulation of interferon-beta production
GO:0035438 cyclic-di-GMP binding
GO:0035458 cellular response to interferon-beta
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043312 neutrophil degranulation
GO:0045087 innate immune response
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048471 perinuclear region of cytoplasm
GO:0050727 regulation of inflammatory response
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051259 protein complex oligomerization
GO:0051607 defense response to virus
GO:0061507 cyclic-GMP-AMP binding
GO:0061709 reticulophagy
GO:0071360 cellular response to exogenous dsRNA
GO:0071407 cellular response to organic cyclic compound
GO:1990701 integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Cytoplasmic vesicle
Endoplasmic reticulum membrane
Endoplasmic reticulum-Golgi intermediate compartment membrane
Mitochondrion outer membrane

Domains

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DomainNameCategoryType
IPR029158 Stimulator of interferon genes proteinFamilyFamily
IPR033952 Stimulator of interferon genes protein, C-terminalDomainDomain
IPR038623 Stimulator of interferon genes protein, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

61 interactions

InteractorPartnerSourcesPublicationsLink
STING_HUMANIF16_HUMANBioGRID, InnateDB20890285 26121674 27764250 30193098 31665637 details
STING_HUMANSTAT6_HUMANIntAct22000020 details
STING_HUMANIRAK1_HUMANBioGRID, IntAct21903422 details
STING_HUMANSTT3A_HUMANBioGRID, IntAct21903422 details
STING_HUMANOST48_HUMANBioGRID, IntAct21903422 details
STING_HUMANSURF4_HUMANBioGRID, IntAct21903422 29251827 details
STING_HUMANSGPL1_HUMANBioGRID, IntAct21903422 details
STING_HUMANCCD47_HUMANBioGRID, IntAct21903422 details
STING_HUMANLTN1_HUMANBioGRID, IntAct21903422 details
STING_HUMANMBOA7_HUMANBioGRID, IntAct21903422 details
STING_HUMANZNF16_HUMANUniProt21874239 details
STING_HUMANSTING_HUMANBioGRID, DIP, HPIDb, IntAct19433799 21074459 22312431 22728658 22728659 22728660 23542348 30018345 30405246 30842659 33086059 details
STING_HUMANCKLF5_HUMANBioGRID, IntAct32296183 details
STING_HUMANPLLP_HUMANBioGRID, IntAct32296183 details
STING_HUMANTECR_HUMANBioGRID, IntAct32296183 details
STING_HUMANREEP6_HUMANBioGRID, IntAct32296183 details
STING_HUMANTM100_HUMANBioGRID, IntAct32296183 details
STING_HUMANYIPF2_HUMANBioGRID, IntAct32296183 details
STING_HUMANSMIM1_HUMANBioGRID, IntAct32296183 details
STING_HUMANSTX5_HUMANBioGRID, IntAct32296183 details
STING_HUMANLERL1_HUMANBioGRID, IntAct32296183 details
STING_HUMANSSRB_HUMANDIP18724357 details
STING_HUMANTRI32_HUMANBioGRID22745133 details
STING_HUMANRNF26_HUMANBioGRID25254379 details
STING_HUMANUBP20_HUMANBioGRID27801882 30814308 details
STING_HUMANUBP49_HUMANBioGRID27801882 30943264 details
STING_HUMANMUL1_HUMANBioGRID28763789 details
STING_HUMANMYSM1_HUMANBioGRID33086059 details
STING_HUMANRN115_HUMANBioGRID33139700 details
STING_HUMANMAVS_HUMANBioGRID, DIP, HPIDb, IntAct18724357 19416887 20080758 22000020 22312431 22908223 22911572 23542348 24622840 details
STING_HUMANTBK1_HUMANBioGRID, DIP, HPIDb, IntAct18724357 19416887 19433799 21074459 21903422 22745133 23542348 24622840 28346439 28763789 29899553 30943264 31534043 32383759 33086059 33139700 details
STING_HUMANDDX58_HUMANBioGRID, DIP, IntAct18724357 22312431 details
STING_HUMANIFIT2_HUMANDIP19416887 details
STING_HUMANIFIT1_HUMANDIP19416887 details
STING_HUMANIKKE_HUMANBioGRID, DIP19433799 22312431 28346439 details
STING_HUMANIRF3_HUMANBioGRID, IntAct24622840 25636800 30018345 33086059 details
STING_HUMANUBB_HUMANIntAct24622840 details
STING_HUMANTRI56_HUMANBioGRID21074459 details
STING_HUMANRNF5_HUMANBioGRID19285439 details
STING_HUMANTSN6_HUMANBioGRID22908223 details
STING_HUMANTOM70_HUMANBioGRID20628368 details
STING_HUMANTRAF3_HUMANBioGRID24622840 27716849 details
STING_HUMANUBP18_HUMANBioGRID27801882 details
STING_HUMANUBP2_HUMANBioGRID27801882 details
STING_HUMANUBP3_HUMANBioGRID27801882 details
STING_HUMANUBP13_HUMANBioGRID27801882 details
STING_HUMANUBP22_HUMANBioGRID27801882 details
STING_HUMANUBP35_HUMANBioGRID27801882 details
STING_HUMANUBP50_HUMANBioGRID27801882 details
STING_HUMANPAN2_HUMANBioGRID27801882 details
STING_HUMANTNR5_HUMANBioGRID27716849 details
STING_HUMANTRAF2_HUMANBioGRID27716849 details
STING_HUMANFAF2_HUMANBioGRID29899553 details
STING_HUMANP53_HUMANBioGRID30193098 details
STING_HUMANTRAF6_HUMANBioGRID30193098 details
STING_HUMANM3K14_HUMANBioGRID30018345 details
STING_HUMANCYLD_HUMANBioGRID30388174 details
STING_HUMANH2B2E_HUMANBioGRID27764250 details
STING_HUMANCGAS_HUMANBioGRID27764250 details
STING_HUMANMARH1_HUMANBioGRID32606244 details
STING_HUMANOTUD5_HUMANBioGRID32879469 details