Entity Details

Primary name DI3L2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8IYB7
EntryNameDI3L2_HUMAN
FullNameDIS3-like exonuclease 2
TaxID9606
Evidenceevidence at protein level
Length885
SequenceStatuscomplete
DateCreated2008-01-15
DateModified2021-06-02

Ontological Relatives

GenesDIS3L2

GO terms

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GOName
GO:0000175 3'-5'-exoribonuclease activity
GO:0000178 exosome (RNase complex)
GO:0000278 mitotic cell cycle
GO:0000287 magnesium ion binding
GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic
GO:0000932 P-body
GO:0004540 ribonuclease activity
GO:0005737 cytoplasm
GO:0005844 polysome
GO:0006402 mRNA catabolic process
GO:0008266 poly(U) RNA binding
GO:0008285 negative regulation of cell population proliferation
GO:0010587 miRNA catabolic process
GO:0019827 stem cell population maintenance
GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
GO:0051301 cell division
GO:0051306 mitotic sister chromatid separation
GO:1990074 polyuridylation-dependent mRNA catabolic process

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001900 Ribonuclease II/RDomainDomain
IPR012340 Nucleic acid-binding, OB-foldFamilyHomologous superfamily
IPR022966 Ribonuclease II/R, conserved siteSiteConserved site
IPR028591 DIS3-like exonuclease 2FamilyFamily
IPR033771 Rrp44-like cold shock domainDomainDomain
IPR041093 DIS3-like exonuclease 2, C-terminalDomainDomain
IPR041505 Dis3-like cold-shock domain 2DomainDomain

Diseases

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Interactions

6 interactions