Entity Details

Primary name GRM8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00222
EntryNameGRM8_HUMAN
FullNameMetabotropic glutamate receptor 8
TaxID9606
Evidenceevidence at protein level
Length908
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesGRM8

GO terms

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GOName
GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity
GO:0001642 group III metabotropic glutamate receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007196 adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
GO:0007216 G protein-coupled glutamate receptor signaling pathway
GO:0007601 visual perception
GO:0008066 glutamate receptor activity
GO:0051966 regulation of synaptic transmission, glutamatergic

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000144 GPCR, family 3, metabotropic glutamate receptor 8FamilyFamily
IPR000162 GPCR, family 3, metabotropic glutamate receptorFamilyFamily
IPR000337 GPCR, family 3FamilyFamily
IPR001828 Receptor, ligand binding regionDomainDomain
IPR011500 GPCR, family 3, nine cysteines domainDomainDomain
IPR017978 GPCR family 3, C-terminalDomainDomain
IPR017979 GPCR, family 3, conserved siteSiteConserved site
IPR028082 Periplasmic binding protein-like IFamilyHomologous superfamily
IPR038550 GPCR, family 3, nine cysteines domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00142 Glutamic acidDrugbanksmall molecule