Entity Details

Primary name P85B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00459
EntryNameP85B_HUMAN
FullNamePhosphatidylinositol 3-kinase regulatory subunit beta
TaxID9606
Evidenceevidence at protein level
Length728
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesPIK3R2

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001678 cellular glucose homeostasis
GO:0001784 phosphotyrosine residue binding
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0006661 phosphatidylinositol biosynthetic process
GO:0008286 insulin receptor signaling pathway
GO:0010506 regulation of autophagy
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0015031 protein transport
GO:0019903 protein phosphatase binding
GO:0030971 receptor tyrosine kinase binding
GO:0032869 cellular response to insulin stimulus
GO:0034976 response to endoplasmic reticulum stress
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042307 positive regulation of protein import into nucleus
GO:0043409 negative regulation of MAPK cascade
GO:0043551 regulation of phosphatidylinositol 3-kinase activity
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046854 phosphatidylinositol phosphate biosynthetic process
GO:0046935 1-phosphatidylinositol-3-kinase regulator activity
GO:0046982 protein heterodimerization activity
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050852 T cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051897 positive regulation of protein kinase B signaling

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000198 Rho GTPase-activating protein domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR008936 Rho GTPase activation proteinFamilyHomologous superfamily
IPR032498 PI3K regulatory subunit p85-related , inter-SH2 domainDomainDomain
IPR035020 PI3K p85 subunit, C-terminal SH2 domainDomainDomain
IPR035022 PI3K p85 subunit, N-terminal SH2 domainDomainDomain
IPR035586 Phosphatidylinositol 3-kinase regulatory subunit beta, SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01064 IsoprenalineDrugbanksmall molecule
DB05210 SF1126Drugbanksmall molecule

Interactions

72 interactions

InteractorPartnerSourcesPublicationsLink
P85B_HUMANKSYK_HUMANBioGRID, HPRD, MINT15536084 details
P85B_HUMANERBB2_HUMANBioGRID, HPRD, MINT1334406 16273093 16729043 22973453 details
P85B_HUMANERBB3_HUMANBioGRID, HPRD, IntAct, MINT16273093 16729043 22973453 24189400 details
P85B_HUMANERBB4_HUMANBioGRID, HPRD, MINT16729043 22973453 details
P85B_HUMANEGFR_HUMANBioGRID, HPRD, IntAct, MINT11172806 1334406 16273093 19531499 22973453 23956138 24658140 25402006 31959764 31980649 details
P85B_HUMANARRB1_HUMANBioGRID, IntAct17620599 21988832 details
P85B_HUMANMED28_HUMANBioGRID, MINT16964398 details
P85B_HUMANIGF1R_HUMANHPRD, IntAct7541045 details
P85B_HUMANGRB2_HUMANBioGRID, HPRD, IntAct19380743 20936779 21706016 8662998 details
P85B_HUMANCRK_HUMANBioGRID, IntAct19380743 25814554 31980649 details
P85B_HUMANCBL_HUMANBioGRID, HPRD, IntAct11133830 15107835 19190244 19380743 25814554 7629144 details
P85B_HUMANABI1_HUMANMINT20598684 details
P85B_HUMANKIT_HUMANBioGRID, HPRD, IntAct, MINT10022833 24728074 7537096 details
P85B_HUMANMR1L1_HUMANBioGRID, IntAct, MINT21516116 25416956 details
P85B_HUMANGRN_HUMANBioGRID, IntAct21988832 details
P85B_HUMANRASK_HUMANBioGRID, IntAct21988832 34079125 details
P85B_HUMANLAMB2_HUMANBioGRID, IntAct21988832 details
P85B_HUMANLTBP3_HUMANBioGRID, IntAct21988832 details
P85B_HUMANSTAB1_HUMANBioGRID, IntAct21988832 details
P85B_HUMANHD_HUMANIntAct17500595 details
P85B_HUMANANDR_HUMANBioGRID, IntAct24728074 details
P85B_HUMANGAB1_HUMANBioGRID, IntAct24728074 details
P85B_HUMANMET_HUMANBioGRID, IntAct24728074 details
P85B_HUMANSTAT3_HUMANBioGRID, IntAct25814554 details
P85B_HUMANDP13A_HUMANBioGRID, IntAct25814554 details
P85B_HUMANKRT38_HUMANBioGRID, IntAct25416956 29892012 details
P85B_HUMANK1C15_HUMANBioGRID, IntAct19380743 25416956 details
P85B_HUMANTRI23_HUMANBioGRID, IntAct25416956 details
P85B_HUMANK1C20_HUMANBioGRID, IntAct25416956 details
P85B_HUMANGOGA2_HUMANBioGRID, IntAct25416956 details
P85B_HUMANDYDC1_HUMANBioGRID, IntAct25416956 details
P85B_HUMANRINT1_HUMANBioGRID, IntAct25416956 details
P85B_HUMANIKZF3_HUMANBioGRID, IntAct25416956 31515488 details
P85B_HUMANSPRE1_HUMANIntAct32814053 details
P85B_HUMANTEC_HUMANBioGRID9178903 details
P85B_HUMANUFO_HUMANBioGRID, HPRD9178760 details
P85B_HUMANFYN_HUMANBioGRID, HPRD1334406 details
P85B_HUMANPK3CD_HUMANBioGRID19380743 9113989 details
P85B_HUMANCRKL_HUMANBioGRID, HPRD11553620 9092574 details
P85B_HUMANA4_HUMANBioGRID21832049 details
P85B_HUMANFBXL2_HUMANBioGRID23604317 details
P85B_HUMANIRS1_HUMANBioGRID, HPRD11120660 12730242 23604317 30240640 7559478 details
P85B_HUMAN1433T_HUMANBioGRID7479742 details
P85B_HUMANGHR_HUMANBioGRID9632636 details
P85B_HUMANCSF1R_HUMANBioGRID, HPRD1334406 details
P85B_HUMANFGFR1_HUMANBioGRID, HPRD15117958 details
P85B_HUMANPTEN_HUMANBioGRID20515662 details
P85B_HUMANLMNA_HUMANBioGRID24623722 details
P85B_HUMANENKUR_HUMANBioGRID15385169 details
P85B_HUMANWASF3_HUMANHPRD15826941 details
P85B_HUMANEPHA2_HUMANHPRD7982920 details
P85B_HUMANHCK_HUMANHPRD, MINT12029088 details
P85B_HUMANPK3CB_HUMANBioGRID, IntAct19380743 22402981 26186194 28514442 details
P85B_HUMANPK3CA_HUMANBioGRID, DIP, IntAct19380743 22402981 23604317 25253337 26496610 27684187 details
P85B_HUMANSHC1_HUMANBioGRID, HPRD, IntAct19380743 8662998 details
P85B_HUMANPGFRB_HUMANHPRD, MINT11172806 1330535 details
P85B_HUMANTGFR2_HUMANBioGRID, HPRD, IntAct26186194 28514442 9435577 details
P85B_HUMANTGFR1_HUMANBioGRID, HPRD9435577 details
P85B_HUMANCCR5_HUMANBioGRID11350939 details
P85B_HUMANSOCS6_HUMANBioGRID, HPRD12052866 details
P85B_HUMANESR1_HUMANBioGRID15020686 details
P85B_HUMANCD28_HUMANBioGRID, HPRD19190244 7509360 8080844 details
P85B_HUMANCD3E_HUMANBioGRID19190244 details
P85B_HUMANCBLB_HUMANBioGRID19190244 details
P85B_HUMANABL1_HUMANBioGRID19380743 details
P85B_HUMANSQSTM_HUMANBioGRID9564850 details
P85B_HUMANSOCS1_HUMANBioGRID, HPRD10022833 29991678 details
P85B_HUMANSOS1_HUMANHPRD9651378 details
P85B_HUMANIRS2_HUMANHPRD10594015 9651378 details
P85B_HUMANSOCS7_HUMANHPRD12052866 details
P85B_HUMANSEPT2_HUMANHPRD17024187 details
P85B_HUMANEGF_HUMANHPRD1334406 details