Entity Details

Primary name GRHL3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8TE85
EntryNameGRHL3_HUMAN
FullNameGrainyhead-like protein 3 homolog
TaxID9606
Evidenceevidence at protein level
Length626
SequenceStatuscomplete
DateCreated2006-03-21
DateModified2021-06-02

Ontological Relatives

GenesGRHL3

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001736 establishment of planar polarity
GO:0001843 neural tube closure
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007389 pattern specification process
GO:0007398 ectoderm development
GO:0007417 central nervous system development
GO:0008544 epidermis development
GO:0010628 positive regulation of gene expression
GO:0031490 chromatin DNA binding
GO:0032956 regulation of actin cytoskeleton organization
GO:0042060 wound healing
GO:0043547 positive regulation of GTPase activity
GO:0043565 sequence-specific DNA binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0061029 eyelid development in camera-type eye
GO:0061436 establishment of skin barrier
GO:0090103 cochlea morphogenesis
GO:0090179 planar cell polarity pathway involved in neural tube closure

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR007604 CP2 transcription factorDomainDomain

Diseases

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Disease IDSourceNameDescription
606713 OMIMVan der Woude syndrome 2 (VWS2)An autosomal dominant developmental disorder characterized by lower lip pits, cleft lip and/or cleft palate. The disease is caused by variants affecting the gene represented in this entry.