Entity Details

Primary name WFKN2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8TEU8
EntryNameWFKN2_HUMAN
FullNameWAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2
TaxID9606
Evidenceevidence at protein level
Length576
SequenceStatuscomplete
DateCreated2007-10-23
DateModified2021-06-02

Ontological Relatives

GenesWFIKKN2

GO terms

Show/Hide Table
GOName
GO:0001501 skeletal system development
GO:0004857 enzyme inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005615 extracellular space
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008191 metalloendopeptidase inhibitor activity
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0032091 negative regulation of protein binding
GO:0043392 negative regulation of DNA binding
GO:0048019 receptor antagonist activity
GO:0050431 transforming growth factor beta binding
GO:0060021 roof of mouth development

Subcellular Location

Show/Hide Table
Subcellular Location
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR001134 Netrin domainDomainDomain
IPR002223 Pancreatic trypsin inhibitor Kunitz domainDomainDomain
IPR002350 Kazal domainDomainDomain
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008197 WAP-type 'four-disulfide core' domainDomainDomain
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-foldFamilyHomologous superfamily
IPR013098 Immunoglobulin I-setDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR018933 Netrin module, non-TIMP typeDomainDomain
IPR020901 Proteinase inhibitor I2, Kunitz, conserved siteSiteConserved site
IPR033638 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1/2FamilyFamily
IPR036058 Kazal domain superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR036645 Elafin-like superfamilyFamilyHomologous superfamily
IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table