Entity Details

Primary name ABCA5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8WWZ7
EntryNameABCA5_HUMAN
FullNameCholesterol transporter ABCA5
TaxID9606
Evidenceevidence at protein level
Length1642
SequenceStatuscomplete
DateCreated2006-10-03
DateModified2021-06-02

Ontological Relatives

GenesABCA5

GO terms

Show/Hide Table
GOName
GO:0000139 Golgi membrane
GO:0005319 lipid transporter activity
GO:0005524 ATP binding
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0006869 lipid transport
GO:0008203 cholesterol metabolic process
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010874 regulation of cholesterol efflux
GO:0016021 integral component of membrane
GO:0031902 late endosome membrane
GO:0033344 cholesterol efflux
GO:0034375 high-density lipoprotein particle remodeling
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0042632 cholesterol homeostasis
GO:0043231 intracellular membrane-bounded organelle
GO:0043691 reverse cholesterol transport
GO:1903064 positive regulation of reverse cholesterol transport

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Golgi apparatus membrane
Late endosome membrane
Lysosome membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR003439 ABC transporter-like, ATP-binding domainDomainDomain
IPR003593 AAA+ ATPase domainDomainDomain
IPR017871 ABC transporter-like, conserved siteSiteConserved site
IPR026082 ABC transporter AFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR030367 ATP-binding cassette subfamily A member 5FamilyFamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00864 TacrolimusDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
ABCA5_HUMANCP2E1_HUMANBioGRID, IntAct21988832 details
ABCA5_HUMANNR4A1_HUMANBioGRID, IntAct21988832 details