Entity Details

Primary name RFFL_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8WZ73
EntryNameRFFL_HUMAN
FullNameE3 ubiquitin-protein ligase rififylin
TaxID9606
Evidenceevidence at protein level
Length363
SequenceStatuscomplete
DateCreated2005-09-27
DateModified2021-06-02

Ontological Relatives

GenesRFFL

GO terms

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GOName
GO:0002020 protease binding
GO:0002039 p53 binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006915 apoptotic process
GO:0010008 endosome membrane
GO:0010762 regulation of fibroblast migration
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0016020 membrane
GO:0019901 protein kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0032006 regulation of TOR signaling
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0046872 metal ion binding
GO:0055038 recycling endosome membrane
GO:0061630 ubiquitin protein ligase activity
GO:0070936 protein K48-linked ubiquitination
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1901797 negative regulation of signal transduction by p53 class mediator
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Recycling endosome membrane

Domains

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DomainNameCategoryType
IPR001841 Zinc finger, RING-typeDomainDomain
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR036361 SAP domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

38 interactions

InteractorPartnerSourcesPublicationsLink
RFFL_HUMANUB2G2_HUMANBioGRID, IntAct19690564 details
RFFL_HUMANCRYA2_HUMANIntAct32814053 details
RFFL_HUMANF13A_HUMANIntAct32814053 details
RFFL_HUMANHNRH3_HUMANIntAct32814053 details
RFFL_HUMANPAK1_HUMANIntAct32814053 details
RFFL_HUMANPGH1_HUMANIntAct32814053 details
RFFL_HUMANGAB2_HUMANIntAct32814053 details
RFFL_HUMANGIPC1_HUMANIntAct32814053 details
RFFL_HUMANZDH17_HUMANIntAct32814053 details
RFFL_HUMANBACE2_HUMANIntAct32814053 details
RFFL_HUMANCSEN_HUMANIntAct32814053 details
RFFL_HUMANUBP5_HUMANBioGRID22626734 details
RFFL_HUMANATX3_HUMANBioGRID22626734 details
RFFL_HUMANUBP7_HUMANBioGRID22626734 details
RFFL_HUMANOTUB1_HUMANBioGRID22626734 details
RFFL_HUMANUCHL5_HUMANBioGRID22626734 details
RFFL_HUMANOTUB2_HUMANBioGRID22626734 details
RFFL_HUMANATX3L_HUMANBioGRID22626734 details
RFFL_HUMANUBP28_HUMANBioGRID22626734 details
RFFL_HUMANESPL1_HUMANBioGRID22626734 details
RFFL_HUMANSTAM1_HUMANBioGRID22626734 details
RFFL_HUMANUB2D3_HUMANBioGRID22626734 23695783 30659120 details
RFFL_HUMANUB2D2_HUMANBioGRID23695783 23871895 details
RFFL_HUMANRFFL_HUMANBioGRID23695783 23871895 details
RFFL_HUMANRIPK1_HUMANBioGRID18450452 details
RFFL_HUMANUB2D1_HUMANBioGRID18450452 details
RFFL_HUMANUBE2N_HUMANBioGRID23695783 details
RFFL_HUMANUB2V2_HUMANBioGRID23695783 details
RFFL_HUMANRFIP1_HUMANBioGRID30659120 details
RFFL_HUMANMILK1_HUMANBioGRID30659120 details
RFFL_HUMANEHD1_HUMANBioGRID30659120 details
RFFL_HUMANOPTN_HUMANBioGRID30659120 details
RFFL_HUMANCASP8_HUMANUniProt15069192 details
RFFL_HUMANP53_HUMANBioGRID17121812 18382127 details
RFFL_HUMANMDM2_HUMANBioGRID18382127 details
RFFL_HUMANRFIP5_HUMANBioGRID30659120 details
RFFL_HUMANKCNH2_HUMANBioGRID30401747 details
RFFL_HUMANTERA_HUMANBioGRID30401747 details