Entity Details

Primary name CTHR1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96CG8
EntryNameCTHR1_HUMAN
FullNameCollagen triple helix repeat-containing protein 1
TaxID9606
Evidenceevidence at protein level
Length243
SequenceStatuscomplete
DateCreated2005-05-10
DateModified2021-06-02

Ontological Relatives

GenesCTHRC1

GO terms

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GOName
GO:0005109 frizzled binding
GO:0005576 extracellular region
GO:0005581 collagen trimer
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0016477 cell migration
GO:0017147 Wnt-protein binding
GO:0032092 positive regulation of protein binding
GO:0033690 positive regulation of osteoblast proliferation
GO:0043932 ossification involved in bone remodeling
GO:0045669 positive regulation of osteoblast differentiation
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060122 inner ear receptor cell stereocilium organization
GO:0062023 collagen-containing extracellular matrix
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090103 cochlea morphogenesis
GO:0090177 establishment of planar polarity involved in neural tube closure

Subcellular Location

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Subcellular Location
Secreted

Domains

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Diseases

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Disease IDSourceNameDescription
614266 OMIMBarrett esophagus (BE)A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
CTHR1_HUMANZDH17_HUMANBioGRID, IntAct24705354 details
CTHR1_HUMANAP2C_HUMANIntAct24835590 details