Entity Details

Primary name AURKA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14965
EntryNameAURKA_HUMAN
FullNameAurora kinase A
TaxID9606
Evidenceevidence at protein level
Length403
SequenceStatuscomplete
DateCreated2003-01-27
DateModified2021-06-02

Ontological Relatives

GenesAURKA

GO terms

Show/Hide Table
GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005813 centrosome
GO:0005814 centriole
GO:0005819 spindle
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005929 cilium
GO:0006468 protein phosphorylation
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007051 spindle organization
GO:0007052 mitotic spindle organization
GO:0007057 spindle assembly involved in female meiosis I
GO:0007100 mitotic centrosome separation
GO:0009611 response to wounding
GO:0009948 anterior/posterior axis specification
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0010629 negative regulation of gene expression
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
GO:0015630 microtubule cytoskeleton
GO:0018105 peptidyl-serine phosphorylation
GO:0019901 protein kinase binding
GO:0030496 midbody
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0031616 spindle pole centrosome
GO:0031625 ubiquitin protein ligase binding
GO:0031647 regulation of protein stability
GO:0032091 negative regulation of protein binding
GO:0032133 chromosome passenger complex
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032465 regulation of cytokinesis
GO:0035174 histone serine kinase activity
GO:0042585 germinal vesicle
GO:0043066 negative regulation of apoptotic process
GO:0043203 axon hillock
GO:0045120 pronucleus
GO:0045840 positive regulation of mitotic nuclear division
GO:0046605 regulation of centrosome cycle
GO:0046777 protein autophosphorylation
GO:0046982 protein heterodimerization activity
GO:0048471 perinuclear region of cytoplasm
GO:0051233 spindle midzone
GO:0051301 cell division
GO:0051642 centrosome localization
GO:0071539 protein localization to centrosome
GO:0072687 meiotic spindle
GO:0097421 liver regeneration
GO:0097431 mitotic spindle pole
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900195 positive regulation of oocyte maturation
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1990138 neuron projection extension

Subcellular Location

Show/Hide Table
Subcellular Location
Cell projection
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR030611 Aurora kinase ADomainDomain
IPR030616 Aurora kinaseFamilyFamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB02482 PhosphonothreonineDrugbanksmall molecule
DB05169 AT9283Drugbanksmall molecule
DB05198 CYC116Drugbanksmall molecule
DB05220 AlisertibDrugbanksmall molecule
DB06134 SNS-314Drugbanksmall molecule
DB06347 CenisertibDrugbanksmall molecule
DB06486 EnzastaurinDrugbanksmall molecule
DB07186 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDEDrugbanksmall molecule
DB07266 AKI-001Drugbanksmall molecule
DB07360 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]ureaDrugbanksmall molecule
DB07362 1-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]ureaDrugbanksmall molecule
DB07545 N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]PHENYL}CYCLOPROPANECARBOXAMIDEDrugbanksmall molecule
DB07801 N-butyl-3-{[6-(9H-purin-6-ylamino)hexanoyl]amino}benzamideDrugbanksmall molecule
DB08065 2-(1H-pyrazol-3-yl)-1H-benzimidazoleDrugbanksmall molecule
DB08066 N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDEDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB13061 MLN8054Drugbanksmall molecule

Interactions

195 interactions

InteractorPartnerSourcesPublicationsLink
AURKA_HUMANAKIP_HUMANBioGRID, HPRD, IntAct12244051 17452972 details
AURKA_HUMANTACC1_HUMANBioGRID, HPRD, IntAct14602875 14603251 15064709 details
AURKA_HUMANCKAP5_HUMANHPRD, IntAct14603251 details
AURKA_HUMANTPX2_HUMANBioGRID, DIP, HPRD, IntAct12177045 14580337 14600264 18773538 19357306 20360068 22110403 26186194 26831064 28514442 details
AURKA_HUMANMYCN_HUMANBioGRID, IntAct19111882 19997598 23792191 25175806 27728805 27837025 details
AURKA_HUMANAURKA_HUMANBioGRID, HPRD, IntAct12490715 14602875 20360068 29515234 details
AURKA_HUMANHNRPK_HUMANBioGRID, MINT21821029 28218735 details
AURKA_HUMANP73_HUMANBioGRID, IntAct22340593 details
AURKA_HUMANSRPK2_HUMANBioGRID, IntAct23602568 details
AURKA_HUMANSRPK1_HUMANBioGRID, IntAct23602568 details
AURKA_HUMANAKT1_HUMANBioGRID, MINT24412244 28205554 details
AURKA_HUMANAN32B_HUMANBioGRID, MINT24412244 details
AURKA_HUMANBAAT_HUMANBioGRID, MINT24412244 details
AURKA_HUMANCDK8_HUMANBioGRID, MINT24412244 details
AURKA_HUMANTRMO_HUMANBioGRID, MINT24412244 details
AURKA_HUMANTSTD2_HUMANBioGRID, MINT24412244 details
AURKA_HUMANCOR2A_HUMANBioGRID, MINT24412244 details
AURKA_HUMANCYLC2_HUMANBioGRID, MINT24412244 details
AURKA_HUMANIBP3_HUMANBioGRID, MINT24412244 details
AURKA_HUMANF16P2_HUMANBioGRID, MINT24412244 details
AURKA_HUMANHEMGN_HUMANBioGRID, MINT24412244 details
AURKA_HUMANMAPK3_HUMANMINT24412244 details
AURKA_HUMANLEF1_HUMANBioGRID, MINT24412244 details
AURKA_HUMANMP2K1_HUMANBioGRID, MINT24412244 details
AURKA_HUMANSIAS_HUMANBioGRID, MINT24412244 details
AURKA_HUMANPP2AB_HUMANBioGRID, MINT24412244 details
AURKA_HUMANSC61B_HUMANBioGRID, MINT24412244 details
AURKA_HUMANCANB2_HUMANBioGRID, MINT24412244 details
AURKA_HUMANRASA1_HUMANBioGRID, MINT24412244 details
AURKA_HUMANTBD2A_HUMANBioGRID, MINT24412244 details
AURKA_HUMANSFRP4_HUMANBioGRID, MINT24412244 details
AURKA_HUMANSTX17_HUMANBioGRID, MINT24412244 details
AURKA_HUMANTGFB1_HUMANBioGRID, MINT24412244 details
AURKA_HUMANXPA_HUMANBioGRID, MINT24412244 details
AURKA_HUMANZN189_HUMANBioGRID, MINT24412244 details
AURKA_HUMANZN510_HUMANBioGRID, MINT24412244 details
AURKA_HUMANANGL4_HUMANBioGRID, MINT25640309 details
AURKA_HUMANBEX2_HUMANBioGRID, MINT25640309 details
AURKA_HUMANBLID_HUMANBioGRID, MINT25640309 details
AURKA_HUMANCAD13_HUMANBioGRID, MINT25640309 details
AURKA_HUMANESIP1_HUMANBioGRID, MINT25640309 details
AURKA_HUMANDKK3_HUMANBioGRID, MINT25640309 details
AURKA_HUMANKLK5_HUMANBioGRID, MINT25640309 details
AURKA_HUMANERRFI_HUMANBioGRID, MINT25640309 details
AURKA_HUMANLYPD3_HUMANBioGRID, MINT25640309 details
AURKA_HUMANMTA3_HUMANBioGRID, MINT25640309 details
AURKA_HUMANPDLI2_HUMANBioGRID, MINT25640309 details
AURKA_HUMANARY2_HUMANBioGRID, MINT25640309 details
AURKA_HUMANHOP2_HUMANBioGRID, MINT25640309 details
AURKA_HUMANS10AE_HUMANBioGRID, MINT25640309 details
AURKA_HUMANSG3A1_HUMANBioGRID, MINT25640309 details
AURKA_HUMANTHRSP_HUMANBioGRID, MINT25640309 details
AURKA_HUMANWIF1_HUMANBioGRID, MINT25640309 details
AURKA_HUMANNPM_HUMANBioGRID, MINT23443559 24857377 details
AURKA_HUMANEGFR_HUMANIntAct23520446 details
AURKA_HUMANTACC3_HUMANBioGRID, HPRD, IntAct14602875 26186194 28514442 details
AURKA_HUMANAUNIP_HUMANBioGRID, IntAct20596670 26186194 28514442 details
AURKA_HUMANP53_HUMANBioGRID, HPRD, IntAct12198151 14702041 21761334 23201157 26186194 28514442 30013191 details
AURKA_HUMANPTPRD_HUMANBioGRID, MINT22305495 details
AURKA_HUMANIKKB_HUMANBioGRID, DIP17939994 details
AURKA_HUMANSPAG5_HUMANDIP18361916 details
AURKA_HUMANPLK1_HUMANBioGRID, DIP18615013 18773538 22939629 details
AURKA_HUMANINCE_HUMANBioGRID, DIP11050385 18773538 19357306 details
AURKA_HUMANBIRC5_HUMANBioGRID, DIP19357306 details
AURKA_HUMANHMMR_HUMANBioGRID, DIP22110403 details
AURKA_HUMANNIN_HUMANBioGRID, HPRD12927815 20596670 details
AURKA_HUMANUBE2N_HUMANBioGRID, HPRD12881723 17060341 details
AURKA_HUMANMBD3_HUMANBioGRID12354758 details
AURKA_HUMANNDKA_HUMANBioGRID, HPRD12490715 details
AURKA_HUMANKIF2C_HUMANBioGRID18434591 details
AURKA_HUMANIKBA_HUMANBioGRID17060341 details
AURKA_HUMANTLK1_HUMANBioGRID17940067 details
AURKA_HUMANTLK2_HUMANBioGRID17940067 details
AURKA_HUMANHDAC6_HUMANBioGRID17604723 details
AURKA_HUMANHDAC2_HUMANBioGRID17604723 details
AURKA_HUMANRASF1_HUMANBioGRID21874044 28205554 details
AURKA_HUMANPUM2_HUMANBioGRID21589936 details
AURKA_HUMANH31T_HUMANBioGRID19357306 20603326 21554500 details
AURKA_HUMANLATS2_HUMANBioGRID15147269 21822051 28205554 details
AURKA_HUMANUBP2_HUMANBioGRID21890637 details
AURKA_HUMANMARE2_HUMANBioGRID19696028 details
AURKA_HUMANMARE3_HUMANBioGRID19696028 details
AURKA_HUMANPLK3_HUMANBioGRID15190214 details
AURKA_HUMANPTTG1_HUMANBioGRID19117984 details
AURKA_HUMANARC1B_HUMANBioGRID20603326 details
AURKA_HUMANARPC2_HUMANBioGRID20603326 details
AURKA_HUMANPP1A_HUMANBioGRID, HPRD11551964 details
AURKA_HUMANPP1B_HUMANBioGRID11551964 details
AURKA_HUMANPP1G_HUMANBioGRID, HPRD11551964 30344098 details
AURKA_HUMANCASB_HUMANBioGRID11551964 details
AURKA_HUMANA4_HUMANBioGRID21244100 21832049 details
AURKA_HUMANNDC80_HUMANBioGRID, HPRD14602875 details
AURKA_HUMANNUF2_HUMANBioGRID, HPRD14602875 details
AURKA_HUMANGEMI_HUMANBioGRID23695679 details
AURKA_HUMANCBX3_HUMANBioGRID23829974 details
AURKA_HUMANMDM2_HUMANBioGRID24240108 details
AURKA_HUMANVHL_HUMANBioGRID23785518 28114281 details
AURKA_HUMANTCAL2_HUMANBioGRID23443559 28218735 details
AURKA_HUMANGA45A_HUMANBioGRID16772293 20460379 details
AURKA_HUMANUBC9_HUMANBioGRID21554500 details
AURKA_HUMANCASL_HUMANBioGRID23539442 details
AURKA_HUMANUBP21_HUMANBioGRID26446837 details
AURKA_HUMANOTU7B_HUMANBioGRID26446837 29973362 details
AURKA_HUMANOTUB1_HUMANBioGRID26446837 details
AURKA_HUMANFOXP1_HUMANBioGRID28218735 details
AURKA_HUMANMYT1_HUMANBioGRID28218735 details
AURKA_HUMANSOX30_HUMANBioGRID28218735 details
AURKA_HUMANSP20H_HUMANBioGRID28218735 details
AURKA_HUMANUBF1_HUMANBioGRID28218735 details
AURKA_HUMANCTCFL_HUMANBioGRID28218735 details
AURKA_HUMANBTK_HUMANBioGRID28218735 details
AURKA_HUMANSSRP1_HUMANBioGRID28218735 details
AURKA_HUMANSTAT2_HUMANBioGRID28218735 details
AURKA_HUMANSOX18_HUMANBioGRID28218735 details
AURKA_HUMANTYY1_HUMANBioGRID28218735 details
AURKA_HUMANTBX10_HUMANBioGRID28218735 details
AURKA_HUMANAATF_HUMANBioGRID28218735 details
AURKA_HUMANSWT1_HUMANBioGRID28218735 details
AURKA_HUMANIF16_HUMANBioGRID28218735 details
AURKA_HUMANZFHX3_HUMANBioGRID28218735 details
AURKA_HUMANREST_HUMANBioGRID28218735 details
AURKA_HUMANATRX_HUMANBioGRID28218735 details
AURKA_HUMANMYT1L_HUMANBioGRID28218735 details
AURKA_HUMANTCRG1_HUMANBioGRID28218735 details
AURKA_HUMANSRBP2_HUMANBioGRID28218735 details
AURKA_HUMANPO4F3_HUMANBioGRID28218735 details
AURKA_HUMANTRRAP_HUMANBioGRID28218735 details
AURKA_HUMANMED26_HUMANBioGRID28218735 details
AURKA_HUMANSIN3B_HUMANBioGRID28218735 details
AURKA_HUMANTF3C4_HUMANBioGRID28218735 details
AURKA_HUMANNFXL1_HUMANBioGRID28218735 details
AURKA_HUMANFOXF1_HUMANBioGRID28218735 details
AURKA_HUMANAP2B_HUMANBioGRID28218735 details
AURKA_HUMANZKSC2_HUMANBioGRID28218735 details
AURKA_HUMANHNRPF_HUMANBioGRID28218735 details
AURKA_HUMANKLH18_HUMANBioGRID23213400 details
AURKA_HUMANFANCA_HUMANBioGRID27398318 details
AURKA_HUMANB2CL1_HUMANBioGRID22617334 details
AURKA_HUMANUBE2C_HUMANBioGRID29973362 details
AURKA_HUMANPAR10_HUMANBioGRID29515234 details
AURKA_HUMANNSD2_HUMANBioGRID30013191 details
AURKA_HUMANEHMT2_HUMANBioGRID30013191 details
AURKA_HUMANPSN2_HUMANBioGRID27293189 details
AURKA_HUMANFZR1_HUMANBioGRID28205554 30498084 details
AURKA_HUMANCCNE1_HUMANBioGRID28205554 details
AURKA_HUMANEPHA2_HUMANBioGRID28205554 details
AURKA_HUMANTSC1_HUMANBioGRID28205554 details
AURKA_HUMANCCND2_HUMANBioGRID28205554 details
AURKA_HUMANMP2K3_HUMANBioGRID28205554 28628118 details
AURKA_HUMANMYC_HUMANBioGRID28205554 details
AURKA_HUMANMERL_HUMANBioGRID28205554 details
AURKA_HUMANSOX4_HUMANBioGRID28205554 details
AURKA_HUMANTFE2_HUMANBioGRID28205554 details
AURKA_HUMANM3K5_HUMANBioGRID28205554 details
AURKA_HUMANSTK11_HUMANBioGRID28205554 details
AURKA_HUMANTEAD2_HUMANBioGRID28205554 details
AURKA_HUMANBRAF_HUMANBioGRID28205554 details
AURKA_HUMANDACH1_HUMANBioGRID28205554 details
AURKA_HUMANERBB2_HUMANBioGRID28205554 details
AURKA_HUMANHIF1A_HUMANBioGRID28205554 details
AURKA_HUMANPGFRA_HUMANBioGRID28205554 details
AURKA_HUMANTF65_HUMANBioGRID28205554 details
AURKA_HUMANSOX3_HUMANBioGRID28205554 details
AURKA_HUMANMBP_HUMANBioGRID20596670 details
AURKA_HUMANH31_HUMANBioGRID20596670 details
AURKA_HUMANPAX8_HUMANBioGRID31391550 details
AURKA_HUMANMK03_HUMANBioGRID24412244 details
AURKA_HUMANSPOP_HUMANBioGRID33158056 details
AURKA_HUMANFABP5_HUMANIntAct17353931 details
AURKA_HUMANJTB_HUMANUniProt21225229 details
AURKA_HUMANCDC20_HUMANBioGRID, HPRD, IntAct10377410 22340593 details
AURKA_HUMANRED_HUMANMINT24996188 details
AURKA_HUMANIKKA_HUMANBioGRID, DIP17939994 details
AURKA_HUMANFBW1A_HUMANBioGRID, DIP17939994 details
AURKA_HUMANNEMO_HUMANBioGRID, DIP17939994 details
AURKA_HUMANBORA_HUMANDIP, HPRD16890155 18615013 details
AURKA_HUMANBRCA1_HUMANBioGRID, DIP, HPRD14990569 22110403 26831064 details
AURKA_HUMANESR1_HUMANBioGRID, IntAct21761334 31527615 details
AURKA_HUMANCHFR_HUMANBioGRID, HPRD15793587 18592005 19182791 details
AURKA_HUMANFBXW7_HUMANBioGRID19111882 22513362 28209614 33086033 details
AURKA_HUMANAP2A_HUMANBioGRID21829699 details
AURKA_HUMANCP131_HUMANBioGRID17452972 details
AURKA_HUMANGSK3B_HUMANBioGRID, HPRD19060929 22513362 23204235 details
AURKA_HUMANBARD1_HUMANBioGRID22350409 details
AURKA_HUMANPML_HUMANBioGRID, HPRD15749021 details
AURKA_HUMANMARE1_HUMANBioGRID19696028 details
AURKA_HUMANTBG1_HUMANBioGRID20603326 details
AURKA_HUMANDAB2_HUMANBioGRID22323290 details
AURKA_HUMANB2L11_HUMANBioGRID23912711 details
AURKA_HUMANAURKB_HUMANBioGRID23443559 28595628 details
AURKA_HUMANPRKN_HUMANBioGRID26387737 details
AURKA_HUMANCUL3_HUMANBioGRID23213400 details
AURKA_HUMANTP4A3_HUMANBioGRID30498084 details
AURKA_HUMANKAPCA_HUMANHPRD11039908 details
AURKA_HUMANKIF11_HUMANHPRD17939994 details