Entity Details

Primary name TBX5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99593
EntryNameTBX5_HUMAN
FullNameT-box transcription factor TBX5
TaxID9606
Evidenceevidence at protein level
Length518
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesTBX5

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001708 cell fate specification
GO:0002009 morphogenesis of an epithelium
GO:0003166 bundle of His development
GO:0003167 atrioventricular bundle cell differentiation
GO:0003181 atrioventricular valve morphogenesis
GO:0003197 endocardial cushion development
GO:0003218 cardiac left ventricle formation
GO:0003281 ventricular septum development
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007267 cell-cell signaling
GO:0007389 pattern specification process
GO:0007507 heart development
GO:0008134 transcription factor binding
GO:0008285 negative regulation of cell population proliferation
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0030324 lung development
GO:0030326 embryonic limb morphogenesis
GO:0030336 negative regulation of cell migration
GO:0032991 protein-containing complex
GO:0032993 protein-DNA complex
GO:0035115 embryonic forelimb morphogenesis
GO:0035136 forelimb morphogenesis
GO:0043565 sequence-specific DNA binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051891 positive regulation of cardioblast differentiation
GO:0060039 pericardium development
GO:0060044 negative regulation of cardiac muscle cell proliferation
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization
GO:0060413 atrial septum morphogenesis
GO:0060928 atrioventricular node cell development
GO:0060929 atrioventricular node cell fate commitment
GO:0060980 cell migration involved in coronary vasculogenesis
GO:0072513 positive regulation of secondary heart field cardioblast proliferation
GO:0086019 cell-cell signaling involved in cardiac conduction
GO:0086054 bundle of His cell to Purkinje myocyte communication by electrical coupling
GO:1901846 positive regulation of cell communication by electrical coupling involved in cardiac conduction
GO:1903598 positive regulation of gap junction assembly
GO:1903781 positive regulation of cardiac conduction

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001699 Transcription factor, T-boxFamilyFamily
IPR008967 p53-like transcription factor, DNA-bindingFamilyHomologous superfamily
IPR018186 Transcription factor, T-box, conserved siteSiteConserved site
IPR036960 T-box superfamilyFamilyHomologous superfamily

Diseases

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