Entity Details

Primary name IKKA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15111
EntryNameIKKA_HUMAN
FullNameInhibitor of nuclear factor kappa-B kinase subunit alpha
TaxID9606
Evidenceevidence at protein level
Length745
SequenceStatuscomplete
DateCreated2001-06-01
DateModified2021-06-02

Ontological Relatives

GenesCHUK

GO terms

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GOName
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0003009 skeletal muscle contraction
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007252 I-kappaB phosphorylation
GO:0007266 Rho protein signal transduction
GO:0008384 IkappaB kinase activity
GO:0008385 IkappaB kinase complex
GO:0009615 response to virus
GO:0009636 response to toxic substance
GO:0009653 anatomical structure morphogenesis
GO:0009898 cytoplasmic side of plasma membrane
GO:0010034 response to acetate
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0018105 peptidyl-serine phosphorylation
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032496 response to lipopolysaccharide
GO:0032727 positive regulation of interferon-alpha production
GO:0033194 response to hydroperoxide
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034614 cellular response to reactive oxygen species
GO:0035631 CD40 receptor complex
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038061 NIK/NF-kappaB signaling
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042493 response to drug
GO:0042803 protein homodimerization activity
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043200 response to amino acid
GO:0044877 protein-containing complex binding
GO:0045087 innate immune response
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046982 protein heterodimerization activity
GO:0050852 T cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051146 striated muscle cell differentiation
GO:0051403 stress-activated MAPK cascade
GO:0061847 response to cholecystokinin
GO:0070498 interleukin-1-mediated signaling pathway
GO:0071276 cellular response to cadmium ion
GO:0071356 cellular response to tumor necrosis factor
GO:0097110 scaffold protein binding
GO:0098586 cellular response to virus
GO:1990459 transferrin receptor binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR022007 I-kappa-kinase-beta NEMO binding domainDomainDomain
IPR041185 IKBKB, scaffold dimerization domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00233 Aminosalicylic acidDrugbanksmall molecule
DB00244 MesalazineDrugbanksmall molecule
DB00795 SulfasalazineDrugbanksmall molecule
DB06151 AcetylcysteineDrugbanksmall molecule

Interactions

170 interactions

InteractorPartnerSourcesPublicationsLink
IKKA_HUMANM3K14_HUMANBioGRID, HPRD, IntAct, MINT10094049 10887201 11278268 14743216 15084608 15208311 16286467 16498412 17563756 20348096 25241761 28514442 30833792 31980649 9244310 9520446 details
IKKA_HUMANIKKB_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10733566 10968790 11057907 11080499 11585904 11864612 11971985 12210728 12244103 12486103 14743216 16129692 16286467 16319058 17693255 20434986 20932476 21575199 21784860 21903422 23016877 25241761 25748427 25852190 28514442 30500824 9346241 9346484 9346485 9721103 9751060 9914500 details
IKKA_HUMANNEMO_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt10733566 10968790 10980203 11057907 11080499 11485410 11864612 11877453 12138192 12244103 12459277 12486103 12612076 14743216 15184390 15749833 16126728 16319058 16497931 16583354 16611882 16938294 17000764 17244613 17363973 17568778 17728323 17977820 18079694 18207244 18266467 18462684 18949366 19666608 19815509 19959994 20098747 20368414 20434986 21455180 21703539 21903422 22547678 22605335 22990857 23016877 23131831 23986494 24469399 24618592 25304104 26496610 26500060 27929056 28249776 28514442 30404796 30561431 30913450 32731169 32935379 9751060 details
IKKA_HUMANIKBB_HUMANBioGRID, HPRD, IntAct11485410 14743216 9252186 9346485 9689078 details
IKKA_HUMANIKBA_HUMANBioGRID, HPRD, InnateDB, IntAct, UniProt10094049 10733566 11042193 11080499 11095741 11113112 11809792 11940602 12054687 12138192 12190313 12411322 12486103 12624112 12730857 14743216 15310755 15389589 15590691 15670770 16219905 16286467 16319058 16354686 17053167 17363905 17379600 17384642 18003900 18074035 18501560 18519641 18922877 18949366 19959994 20133937 20434986 20449947 20932476 21765415 23602409 24270572 24618592 26186194 28514442 29958295 9244310 9252186 9346485 9520446 9689078 9721103 9751059 9914500 details
IKKA_HUMANCDC37_HUMANBioGRID, HPRD, IntAct11864612 14743216 21903422 24189400 25036637 details
IKKA_HUMANTRAF2_HUMANBioGRID, HPRD, IntAct11359906 19150425 20449947 23007157 25241761 9244310 details
IKKA_HUMANAKT1_HUMANBioGRID, HPRD, IntAct10485710 10485711 11278366 15710601 15800029 25241761 details
IKKA_HUMANM3K1_HUMANBioGRID16286467 9689078 9819420 details
IKKA_HUMANTNR1A_HUMANBioGRID, HPRD10755617 18949366 21724995 30420664 details
IKKA_HUMANIKKA_HUMANBioGRID, HPRD, IntAct10755617 11585904 14743216 9346485 9520446 9721103 details
IKKA_HUMANNFKB2_HUMANBioGRID, HPRD, IntAct14743216 15140882 16303288 16651533 17563756 18617892 details
IKKA_HUMANNFKB1_HUMANBioGRID, HPRD, IntAct, MINT10469655 11297557 11976329 12482991 25609649 details
IKKA_HUMANUB2E3_HUMANHPRD9409737 details
IKKA_HUMANNCOA3_HUMANBioGRID, HPRD, UniProt11971985 15383283 15808510 16051665 details
IKKA_HUMANSRPK1_HUMANBioGRID, IntAct23602568 details
IKKA_HUMANIRF7_HUMANUniProt18922877 details
IKKA_HUMANCDN1B_HUMANIntAct23602409 details
IKKA_HUMANBCL10_HUMANBioGRID, HPRD11113112 14695475 22547678 details
IKKA_HUMANTF65_HUMANBioGRID, HPRD, IntAct12842894 14743216 15489227 16046471 16382138 17434128 18519641 21903422 22689577 8246997 details
IKKA_HUMANBCL3_HUMANBioGRID28689659 details
IKKA_HUMANTNIP2_HUMANBioGRID, IntAct21784860 30561431 details
IKKA_HUMANM3K11_HUMANBioGRID, HPRD10713178 details
IKKA_HUMANCSN5_HUMANBioGRID19656241 23636414 31950832 details
IKKA_HUMANTRAF4_HUMANBioGRID22547678 details
IKKA_HUMANROA1_HUMANBioGRID24720748 details
IKKA_HUMANATR_HUMANBioGRID21466675 details
IKKA_HUMANIKKE_HUMANBioGRID9914500 details
IKKA_HUMANNCOR1_HUMANBioGRID17630505 details
IKKA_HUMANRL27_HUMANBioGRID, IntAct21988832 details
IKKA_HUMANKPCA_HUMANBioGRID10022904 details
IKKA_HUMANKPCD_HUMANBioGRID10022904 details
IKKA_HUMANFOXO3_HUMANBioGRID, HPRD15084260 details
IKKA_HUMANRICTR_HUMANBioGRID23872070 details
IKKA_HUMANNCOR2_HUMANBioGRID, HPRD15494311 16382138 details
IKKA_HUMANCUED2_HUMANBioGRID18362886 details
IKKA_HUMANCBP_HUMANBioGRID, HPRD, UniProt11971985 12789342 14597638 17434128 details
IKKA_HUMANCTNB1_HUMANBioGRID, HPRD11527961 12589056 details
IKKA_HUMANUBC9_HUMANBioGRID11853669 details
IKKA_HUMANCSK21_HUMANBioGRID9914500 details
IKKA_HUMANM3K8_HUMANBioGRID, HPRD10072079 details
IKKA_HUMANTRI27_HUMANBioGRID16393995 details
IKKA_HUMANP73_HUMANBioGRID17452332 21482671 details
IKKA_HUMANDCNL5_HUMANBioGRID29958295 details
IKKA_HUMANSRPK2_HUMANBioGRID, IntAct23602568 details
IKKA_HUMANPRKDC_HUMANBioGRID, HPRD9632806 details
IKKA_HUMANKPCI_HUMANBioGRID, HPRD10022904 10848576 details
IKKA_HUMANHD_HUMANBioGRID20026656 details
IKKA_HUMANBBC3B_HUMANBioGRID21997190 details
IKKA_HUMANE2F4_HUMANBioGRID18542057 details
IKKA_HUMANTAXB1_HUMANInnateDB21765415 details
IKKA_HUMANH32_HUMANBioGRID17643371 details
IKKA_HUMANBBC3_HUMANBioGRID21997190 details
IKKA_HUMANFANCA_HUMANBioGRID12210728 14499622 details
IKKA_HUMANRIPK2_HUMANBioGRID22547678 details
IKKA_HUMANERBIN_HUMANBioGRID22547678 details
IKKA_HUMANUBC_HUMANBioGRID28190767 details
IKKA_HUMANM3K21_HUMANIntAct26859459 details
IKKA_HUMANUBE2N_HUMANBioGRID11057907 details
IKKA_HUMANFBW1A_HUMANBioGRID12504025 details
IKKA_HUMANPAX8_HUMANBioGRID, IntAct21988832 details
IKKA_HUMANIFIT5_HUMANBioGRID26334375 details
IKKA_HUMANAMRA1_HUMANBioGRID30217973 details
IKKA_HUMANM3K4_HUMANBioGRID22547678 details
IKKA_HUMANGRP75_HUMANIntAct14743216 details
IKKA_HUMANSRC_HUMANBioGRID, HPRD, IntAct12707358 15749833 details
IKKA_HUMANIRAK1_HUMANBioGRID11096118 18180283 details
IKKA_HUMANLRC14_HUMANBioGRID27426725 details
IKKA_HUMANKDF1_HUMANBioGRID32239614 details
IKKA_HUMANMYH14_HUMANBioGRID, IntAct14743216 22863883 details
IKKA_HUMANASC_HUMANBioGRID, UniProt12486103 details
IKKA_HUMANSMAD2_HUMANBioGRID, DIP18268325 details
IKKA_HUMANTP4AP_HUMANBioGRID, HPRD14585990 details
IKKA_HUMANPIAS1_HUMANBioGRID, HPRD17540171 23032264 30982983 details
IKKA_HUMANEGLN3_HUMANBioGRID23732909 details
IKKA_HUMANCOMD7_HUMANBioGRID26060140 details
IKKA_HUMANCAZA1_HUMANIntAct14743216 details
IKKA_HUMANHS90A_HUMANBioGRID, HPRD, IntAct11864612 14743216 19875381 22384180 details
IKKA_HUMANTRAF6_HUMANBioGRID15836773 details
IKKA_HUMANRIPK1_HUMANBioGRID10980203 29955050 details
IKKA_HUMANSASH1_HUMANBioGRID23776175 details
IKKA_HUMANPP4C_HUMANBioGRID27391343 details
IKKA_HUMANPP2AA_HUMANBioGRID, MINT16126728 details
IKKA_HUMANTANK_HUMANBioGRID, HPRD, IntAct12133833 30561431 details
IKKA_HUMANPEBP1_HUMANHPRD11585904 details
IKKA_HUMANFKBP5_HUMANBioGRID, HPRD, IntAct14743216 25036637 details
IKKA_HUMANSMAD3_HUMANBioGRID, DIP18268325 details
IKKA_HUMANELP1_HUMANBioGRID, HPRD10094049 9751059 details
IKKA_HUMANELAV1_HUMANBioGRID23115237 details
IKKA_HUMANMYH9_HUMANIntAct14743216 details
IKKA_HUMANTNFA_HUMANBioGRID20005846 27307491 27545878 details
IKKA_HUMANTRAF1_HUMANBioGRID12709429 19287455 details
IKKA_HUMANESR1_HUMANBioGRID, HPRD15808510 details
IKKA_HUMANA16L2_HUMANBioGRID23563314 details
IKKA_HUMANPTEN_HUMANBioGRID26787927 details
IKKA_HUMANTFR1_HUMANBioGRID23016877 details
IKKA_HUMANEF1A2_HUMANIntAct14743216 details
IKKA_HUMANTNAP3_HUMANBioGRID, HPRD11594795 details
IKKA_HUMANCIKS_HUMANBioGRID, HPRD10962033 12943667 details
IKKA_HUMANRPTOR_HUMANBioGRID18519641 details
IKKA_HUMANP53_HUMANBioGRID, HPRD11805286 17434128 details
IKKA_HUMANMAVS_HUMANUniProt16177806 details
IKKA_HUMANRB6I2_HUMANBioGRID15218148 details
IKKA_HUMANRNF8_HUMANBioGRID28499869 details
IKKA_HUMANNOTC3_HUMANHPRD17289033 details
IKKA_HUMANM3K7_HUMANBioGRID, HPRD, IntAct, MINT10094049 10187861 16893890 20200282 25241761 9742107 details
IKKA_HUMANTBA3D_HUMANIntAct14743216 details
IKKA_HUMANRELB_HUMANIntAct14743216 details
IKKA_HUMANMTOR_HUMANBioGRID18490760 18519641 details
IKKA_HUMANMYC_HUMANBioGRID, Molecular Connections21575199 details
IKKA_HUMANPPM1B_HUMANBioGRID, IntAct14585847 25241761 details
IKKA_HUMANAURKA_HUMANBioGRID, DIP17939994 details
IKKA_HUMANE2AK2_HUMANBioGRID, HPRD10648614 10723127 10848580 details
IKKA_HUMANKPCT_HUMANBioGRID, HPRD15802604 17363905 20164171 details
IKKA_HUMANCSN3_HUMANBioGRID23636414 details
IKKA_HUMANCLH1_HUMANIntAct14743216 details
IKKA_HUMANML12A_HUMANBioGRID, IntAct14743216 22863883 details
IKKA_HUMANMYO1D_HUMANIntAct14743216 details
IKKA_HUMANCUL1_HUMANBioGRID, HPRD17914462 details
IKKA_HUMANIRF5_HUMANBioGRID19786094 details
IKKA_HUMANPSMD9_HUMANBioGRID24720748 details
IKKA_HUMANUBP18_HUMANBioGRID26240016 details
IKKA_HUMANSKP2_HUMANBioGRID29474632 details
IKKA_HUMANTPM3_HUMANIntAct14743216 details
IKKA_HUMANHS90B_HUMANHPRD, IntAct14743216 details
IKKA_HUMANTBA3C_HUMANIntAct14743216 details
IKKA_HUMANP63_HUMANBioGRID20145131 details
IKKA_HUMANTRI22_HUMANBioGRID25510414 details
IKKA_HUMANMYH10_HUMANIntAct14743216 details
IKKA_HUMANTNR1B_HUMANBioGRID19287455 details
IKKA_HUMANCHIP_HUMANBioGRID23322406 details
IKKA_HUMANDUS1_HUMANBioGRID10022904 details
IKKA_HUMANMAGD1_HUMANBioGRID20100315 details
IKKA_HUMANKPCB_HUMANBioGRID, HPRD, IntAct12070292 25241761 details
IKKA_HUMANTPX2_HUMANBioGRID, DIP17939994 details
IKKA_HUMANCASP8_HUMANBioGRID, HPRD11002417 details
IKKA_HUMANCAR11_HUMANBioGRID16356855 18625728 details
IKKA_HUMANM3K3_HUMANBioGRID, IntAct14743216 25241761 details
IKKA_HUMANNALP4_HUMANBioGRID, HPRD12093792 details
IKKA_HUMANCLUS_HUMANBioGRID20028970 details
IKKA_HUMANHSPB1_HUMANBioGRID16840786 details
IKKA_HUMANTBB5_HUMANIntAct14743216 details
IKKA_HUMANNALP2_HUMANBioGRID15456791 details
IKKA_HUMANPP4R1_HUMANBioGRID27391343 details
IKKA_HUMANTBB4A_HUMANIntAct14743216 details
IKKA_HUMANBCL2_HUMANBioGRID22262057 details
IKKA_HUMANCHK1_HUMANHPRD17962807 details
IKKA_HUMANACTG_HUMANIntAct14743216 details
IKKA_HUMANTRADD_HUMANBioGRID10980203 details
IKKA_HUMANSMN_HUMANBioGRID28214532 details
IKKA_HUMANATM_HUMANBioGRID32731169 details
IKKA_HUMANTGFR1_HUMANHPRD15761153 details
IKKA_HUMANCSF2R_HUMANHPRD12637324 details
IKKA_HUMANPTN11_HUMANHPRD11136824 details
IKKA_HUMANMYL6_HUMANIntAct14743216 details
IKKA_HUMANKEAP1_HUMANBioGRID, IntAct20600852 30500824 details
IKKA_HUMANTRI40_HUMANBioGRID21474709 details
IKKA_HUMANPP1A_HUMANBioGRID18949366 details
IKKA_HUMANGLI1_HUMANBioGRID26603838 details
IKKA_HUMANH31T_HUMANHPRD12789342 details
IKKA_HUMANAKT2_HUMANHPRD12048203 details
IKKA_HUMANEP300_HUMANBioGRID19838210 details
IKKA_HUMANPP4R2_HUMANBioGRID27391343 details
IKKA_HUMANNR2C2_HUMANHPRD12547194 details
IKKA_HUMANIKBE_HUMANIntAct14743216 details
IKKA_HUMANTAB2_HUMANBioGRID15836773 details
IKKA_HUMANCALM2_HUMANIntAct14743216 details
IKKA_HUMANIRS1_HUMANBioGRID, HPRD12351658 details
IKKA_HUMANTNR5_HUMANBioGRID20614026 details
IKKA_HUMANKLH21_HUMANBioGRID27387502 details