Entity Details

Primary name S22A1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15245
EntryNameS22A1_HUMAN
FullNameSolute carrier family 22 member 1
TaxID9606
Evidenceevidence at protein level
Length554
SequenceStatuscomplete
DateCreated2008-05-20
DateModified2021-06-02

Ontological Relatives

GenesSLC22A1

GO terms

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GOName
GO:0005277 acetylcholine transmembrane transporter activity
GO:0005326 neurotransmitter transmembrane transporter activity
GO:0005330 dopamine:sodium symporter activity
GO:0005334 norepinephrine:sodium symporter activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006836 neurotransmitter transport
GO:0008504 monoamine transmembrane transporter activity
GO:0008513 secondary active organic cation transmembrane transporter activity
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
GO:0015101 organic cation transmembrane transporter activity
GO:0015214 pyrimidine nucleoside transmembrane transporter activity
GO:0015651 quaternary ammonium group transmembrane transporter activity
GO:0015695 organic cation transport
GO:0015697 quaternary ammonium group transport
GO:0015874 norepinephrine transport
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0019534 toxin transmembrane transporter activity
GO:0042802 identical protein binding
GO:0042908 xenobiotic transport
GO:0042910 xenobiotic transmembrane transporter activity
GO:0048241 epinephrine transport
GO:0051610 serotonin uptake
GO:0072530 purine-containing compound transmembrane transport
GO:0090494 dopamine uptake
GO:0098793 presynapse
GO:0150104 transport across blood-brain barrier
GO:1901998 toxin transport
GO:1990962 xenobiotic transport across blood-brain barrier

Subcellular Location

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Subcellular Location
Basolateral cell membrane

Domains

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DomainNameCategoryType
IPR004749 Organic cation transport protein/SVOPFamilyFamily
IPR005828 Major facilitator, sugar transporter-likeFamilyFamily
IPR005829 Sugar transporter, conserved siteSiteConserved site
IPR020846 Major facilitator superfamily domainDomainDomain
IPR036259 MFS transporter superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00122 CholineDrugbanksmall molecule
DB00127 SpermineDrugbanksmall molecule
DB00152 ThiamineDrugbanksmall molecule
DB00184 NicotineDrugbanksmall molecule
DB00206 ReserpineDrugbanksmall molecule
DB00220 NelfinavirDrugbanksmall molecule
DB00224 IndinavirDrugbanksmall molecule
DB00238 NevirapineDrugbanksmall molecule
DB00280 DisopyramideDrugbanksmall molecule
DB00318 CodeineDrugbanksmall molecule
DB00331 MetforminDrugbanksmall molecule
DB00368 NorepinephrineDrugbanksmall molecule
DB00396 ProgesteroneDrugbanksmall molecule
DB00406 Gentian violet cationSwissprotsmall molecule
DB00413 PramipexoleDrugbanksmall molecule
DB00448 LansoprazoleDrugbanksmall molecule
DB00457 PrazosinDrugbanksmall molecule
DB00468 QuinineDrugbanksmall molecule
DB00501 CimetidineDrugbanksmall molecule
DB00520 CaspofunginDrugbanksmall molecule
DB00536 GuanidineDrugbanksmall molecule
DB00555 LamotrigineDrugbanksmall molecule
DB00590 DoxazosinDrugbanksmall molecule
DB00619 ImatinibDrugbanksmall molecule
DB00625 EfavirenzDrugbanksmall molecule
DB00661 VerapamilDrugbanksmall molecule
DB00668 EpinephrineDrugbanksmall molecule
DB00709 LamivudineDrugbanksmall molecule
DB00728 RocuroniumDrugbanksmall molecule
DB00758 ClopidogrelDrugbanksmall molecule
DB00787 AcyclovirDrugbanksmall molecule
DB00863 RanitidineDrugbanksmall molecule
DB00908 QuinidineDrugbanksmall molecule
DB00914 PhenforminDrugbanksmall molecule
DB00915 AmantadineDrugbanksmall molecule
DB00925 PhenoxybenzamineDrugbanksmall molecule
DB00938 SalmeterolDrugbanksmall molecule
DB00983 FormoterolDrugbanksmall molecule
DB00988 DopamineDrugbanksmall molecule
DB01004 GanciclovirDrugbanksmall molecule
DB01018 GuanfacineDrugbanksmall molecule
DB01032 ProbenecidDrugbanksmall molecule
DB01035 ProcainamideDrugbanksmall molecule
DB01114 ChlorpheniramineDrugbanksmall molecule
DB01137 LevofloxacinDrugbanksmall molecule
DB01151 DesipramineDrugbanksmall molecule
DB01199 TubocurarineDrugbanksmall molecule
DB01232 SaquinavirDrugbanksmall molecule
DB01337 PancuroniumDrugbanksmall molecule
DB01621 PipotiazineDrugbanksmall molecule
DB01623 ThiothixeneDrugbanksmall molecule
DB03128 AcetylcholineDrugbanksmall molecule
DB03566 SpermidineDrugbanksmall molecule
DB04830 BuforminSwissprotsmall molecule
DB04855 DronedaroneDrugbanksmall molecule
DB05381 HistamineDrugbanksmall molecule
DB06137 TirbanibulinDrugbanksmall molecule
DB08837 TetraethylammoniumDrugbanksmall molecule
DB08838 AgmatineDrugbanksmall molecule
DB08882 LinagliptinDrugbanksmall molecule
DB09073 PalbociclibDrugbanksmall molecule
DB09079 NintedanibDrugbanksmall molecule
DB09555 Dexchlorpheniramine maleateDrugbanksmall molecule
DB11642 PitolisantDrugbanksmall molecule
DB11732 LasmiditanDrugbanksmall molecule
DB11837 OsilodrostatDrugbanksmall molecule
DB11963 DacomitinibDrugbanksmall molecule
DB12141 GilteritinibDrugbanksmall molecule
DB12267 BrigatinibDrugbanksmall molecule
DB12332 RucaparibDrugbanksmall molecule
DB12598 NafamostatDrugbanksmall molecule
DB12674 LurbinectedinSwissprotsmall molecule
DB13952 Estradiol acetateDrugbanksmall molecule
DB13953 Estradiol benzoateDrugbanksmall molecule
DB13954 Estradiol cypionateDrugbanksmall molecule
DB13955 Estradiol dienanthateDrugbanksmall molecule
DB13956 Estradiol valerateDrugbanksmall molecule
DB14006 Choline salicylateDrugbanksmall molecule