Entity Details

Primary name CLIC2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15247
EntryNameCLIC2_HUMAN
FullNameChloride intracellular channel protein 2
TaxID9606
Evidenceevidence at protein level
Length247
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesCLIC2

GO terms

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GOName
GO:0004602 glutathione peroxidase activity
GO:0005244 voltage-gated ion channel activity
GO:0005254 chloride channel activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006749 glutathione metabolic process
GO:0007165 signal transduction
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0034707 chloride channel complex
GO:0051099 positive regulation of binding
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity
GO:1902476 chloride transmembrane transport

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane

Domains

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DomainNameCategoryType
IPR002946 Intracellular chloride channelFamilyFamily
IPR004045 Glutathione S-transferase, N-terminalDomainDomain
IPR010987 Glutathione S-transferase, C-terminal-likeDomainDomain
IPR030253 Chloride intracellular channel protein 2FamilyFamily
IPR036249 Thioredoxin-like superfamilyFamilyHomologous superfamily
IPR036282 Glutathione S-transferase, C-terminal domain superfamilyFamilyHomologous superfamily
IPR040079 Glutathione Transferase familyFamilyFamily

Diseases

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Interactions

5 interactions