Entity Details

Primary name FTO_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9C0B1
EntryNameFTO_HUMAN
FullNameAlpha-ketoglutarate-dependent dioxygenase FTO
TaxID9606
Evidenceevidence at protein level
Length505
SequenceStatuscomplete
DateCreated2007-05-01
DateModified2021-06-02

Ontological Relatives

GenesFTO

GO terms

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GOName
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006307 DNA dealkylation involved in DNA repair
GO:0008198 ferrous iron binding
GO:0010883 regulation of lipid storage
GO:0016607 nuclear speck
GO:0016740 transferase activity
GO:0035515 oxidative RNA demethylase activity
GO:0035516 oxidative DNA demethylase activity
GO:0035552 oxidative single-stranded DNA demethylation
GO:0035553 oxidative single-stranded RNA demethylation
GO:0040014 regulation of multicellular organism growth
GO:0042245 RNA repair
GO:0043231 intracellular membrane-bounded organelle
GO:0043734 DNA-N1-methyladenine dioxygenase activity
GO:0061157 mRNA destabilization
GO:0070989 oxidative demethylation
GO:0080111 DNA demethylation
GO:0090335 regulation of brown fat cell differentiation
GO:1990931 RNA N6-methyladenosine dioxygenase activity
GO:1990984 tRNA demethylase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus
Nucleus speckle

Domains

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DomainNameCategoryType
IPR024366 Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminalDomainDomain
IPR024367 Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domainDomainDomain
IPR032868 Alpha-ketoglutarate-dependent dioxygenase FTOFamilyFamily
IPR037151 Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamilyFamilyHomologous superfamily
IPR038413 FTO, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB11638 ArtenimolDrugbanksmall molecule