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Entity Details
Primary name
ISCU_HUMAN
Entity type
UniProt
Source
Source Link
Details
Accession
Q9H1K1
EntryName
ISCU_HUMAN
FullName
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
TaxID
9606
Evidence
evidence at protein level
Length
167
SequenceStatus
complete
DateCreated
2005-04-26
DateModified
2021-06-02
Ontological Relatives
Genes
ISCU
GO terms
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GO
Name
GO:0005506
iron ion binding
GO:0005634
nucleus
GO:0005737
cytoplasm
GO:0005739
mitochondrion
GO:0005759
mitochondrial matrix
GO:0005829
cytosol
GO:0006879
cellular iron ion homeostasis
GO:0008198
ferrous iron binding
GO:0016226
iron-sulfur cluster assembly
GO:0051537
2 iron, 2 sulfur cluster binding
GO:0051539
4 iron, 4 sulfur cluster binding
GO:0060090
molecular adaptor activity
GO:1902958
positive regulation of mitochondrial electron transport, NADH to ubiquinone
GO:1904234
positive regulation of aconitate hydratase activity
GO:1904439
negative regulation of iron ion import across plasma membrane
Subcellular Location
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Subcellular Location
Cytoplasm
Mitochondrion
Nucleus
Domains
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Domain
Name
Category
Type
IPR002871
NIF system FeS cluster assembly, NifU, N-terminal
Domain
Domain
IPR011339
ISC system FeS cluster assembly, IscU scaffold
Family
Family
Diseases
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Drugs
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Interactions
22 interactions
Interactor
Partner
Sources
Publications
Link
ISCU_HUMAN
NECA2_HUMAN
BioGRID, IntAct, MINT
21516116
25416956
details
ISCU_HUMAN
GOGA2_HUMAN
BioGRID, IntAct
25416956
details
ISCU_HUMAN
NUP62_HUMAN
BioGRID, IntAct
25416956
32296183
details
ISCU_HUMAN
CC172_HUMAN
BioGRID, IntAct
25416956
details
ISCU_HUMAN
HPRT_HUMAN
BioGRID, IntAct
25416956
31515488
details
ISCU_HUMAN
IKZF1_HUMAN
BioGRID, IntAct
25416956
details
ISCU_HUMAN
ATRAP_HUMAN
BioGRID, IntAct
25416956
details
ISCU_HUMAN
FAM9B_HUMAN
BioGRID, IntAct
25416956
details
ISCU_HUMAN
BANP_HUMAN
BioGRID, IntAct
25416956
details
ISCU_HUMAN
LNX1_HUMAN
BioGRID, IntAct
25416956
details
ISCU_HUMAN
K1C40_HUMAN
BioGRID, IntAct
25416956
details
ISCU_HUMAN
TRIM1_HUMAN
BioGRID, IntAct
25416956
details
ISCU_HUMAN
PICK1_HUMAN
BioGRID, IntAct
32296183
details
ISCU_HUMAN
KRT34_HUMAN
BioGRID, IntAct
32296183
details
ISCU_HUMAN
CBY2_HUMAN
BioGRID, IntAct
32296183
details
ISCU_HUMAN
GG6L9_HUMAN
BioGRID, IntAct
32296183
details
ISCU_HUMAN
HSC20_HUMAN
BioGRID, DIP, IntAct
24573684
24606901
28380382
details
ISCU_HUMAN
NFS1_HUMAN
BioGRID, IntAct
24573684
31101807
details
ISCU_HUMAN
CC136_HUMAN
BioGRID
32296183
details
ISCU_HUMAN
1433B_HUMAN
IntAct
17353931
details
ISCU_HUMAN
1433S_HUMAN
BioGRID, MINT
15778465
details
ISCU_HUMAN
SDHB_HUMAN
DIP, IntAct
24606901
26749241
details
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