Entity Details

Primary name SOCS1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15524
EntryNameSOCS1_HUMAN
FullNameSuppressor of cytokine signaling 1
TaxID9606
Evidenceevidence at protein level
Length211
SequenceStatuscomplete
DateCreated2002-04-16
DateModified2021-06-02

Ontological Relatives

GenesSOCS1

GO terms

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GOName
GO:0001817 regulation of cytokine production
GO:0001932 regulation of protein phosphorylation
GO:0004860 protein kinase inhibitor activity
GO:0005159 insulin-like growth factor receptor binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0010533 regulation of activation of Janus kinase activity
GO:0016567 protein ubiquitination
GO:0019210 kinase inhibitor activity
GO:0019221 cytokine-mediated signaling pathway
GO:0019901 protein kinase binding
GO:0031410 cytoplasmic vesicle
GO:0035556 intracellular signal transduction
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0038111 interleukin-7-mediated signaling pathway
GO:0040008 regulation of growth
GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein
GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation
GO:0043377 negative regulation of CD8-positive, alpha-beta T cell differentiation
GO:0045444 fat cell differentiation
GO:0045591 positive regulation of regulatory T cell differentiation
GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046854 phosphatidylinositol phosphate biosynthetic process
GO:0046935 1-phosphatidylinositol-3-kinase regulator activity
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0071230 cellular response to amino acid stimulus

Subcellular Location

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Subcellular Location
Cytoplasmic vesicle
Nucleus

Domains

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DomainNameCategoryType
IPR000980 SH2 domainDomainDomain
IPR001496 SOCS box domainDomainDomain
IPR028411 Suppressor of cytokine signalling 1FamilyFamily
IPR035861 SOCS1, SH2 domainDomainDomain
IPR036036 SOCS box-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

82 interactions

InteractorPartnerSourcesPublicationsLink
SOCS1_HUMANERBB2_HUMANBioGRID, MINT16273093 22973453 details
SOCS1_HUMANELOC_HUMANBioGRID, HPRD, IntAct, MINT10051596 16643902 17183367 21119685 22787435 29991678 31980649 details
SOCS1_HUMANCOMD1_HUMANBioGRID, HPRD, MINT17183367 29991678 details
SOCS1_HUMANTF65_HUMANBioGRID, HPRD, MINT14690596 17183367 21084693 29991678 details
SOCS1_HUMANJAK2_HUMANBioGRID, HPRD, MINT10064597 10421843 10455112 11314018 11713228 11971965 14517242 14522994 18508766 19287004 28258213 29674694 29991678 9202126 9344848 details
SOCS1_HUMANM3K5_HUMANBioGRID, MINT16407264 18776134 29991678 details
SOCS1_HUMANMET_HUMANBioGRID, IntAct24728074 25728680 details
SOCS1_HUMANP85A_HUMANBioGRID, HPRD, IntAct10022833 25814554 29991678 details
SOCS1_HUMANCRKL_HUMANBioGRID, IntAct25814554 29991678 details
SOCS1_HUMANCRK_HUMANBioGRID, IntAct10022833 25814554 details
SOCS1_HUMANSH3G1_HUMANBioGRID, IntAct32296183 details
SOCS1_HUMANIGF1R_HUMANBioGRID, HPRD29991678 9727029 details
SOCS1_HUMANCSF1R_HUMANBioGRID, HPRD10022833 11297560 29991678 details
SOCS1_HUMANKIT_HUMANBioGRID, HPRD10022833 29991678 details
SOCS1_HUMANVAV_HUMANBioGRID, HPRD10022833 10747851 29991678 details
SOCS1_HUMANGRB2_HUMANBioGRID, HPRD10022833 29991678 details
SOCS1_HUMANNCK1_HUMANBioGRID, HPRD10022833 29991678 details
SOCS1_HUMANFYN_HUMANBioGRID, HPRD10022833 29991678 details
SOCS1_HUMANITK_HUMANBioGRID, HPRD10022833 29991678 details
SOCS1_HUMANGHR_HUMANBioGRID, HPRD10585430 details
SOCS1_HUMANTEC_HUMANBioGRID, HPRD29991678 9341160 details
SOCS1_HUMANIL2RB_HUMANBioGRID, HPRD11133764 29674694 29991678 details
SOCS1_HUMANEGFR_HUMANBioGRID, HPRD12070153 22973453 29991678 details
SOCS1_HUMANINAR1_HUMANBioGRID21757742 29674694 details
SOCS1_HUMANTYK2_HUMANBioGRID21757742 29674694 29991678 details
SOCS1_HUMANJAK1_HUMANBioGRID, HPRD10707961 11133764 29674694 29991678 details
SOCS1_HUMANLCK_HUMANBioGRID21234523 31101761 details
SOCS1_HUMANINSR_HUMANBioGRID, HPRD11342531 15169905 29991678 details
SOCS1_HUMANP53_HUMANBioGRID20005840 27236107 29991678 31101761 details
SOCS1_HUMANATM_HUMANBioGRID20005840 29991678 details
SOCS1_HUMANCYTIP_HUMANBioGRID23469018 29991678 details
SOCS1_HUMANFAK1_HUMANBioGRID14517242 details
SOCS1_HUMANIRF7_HUMANBioGRID29712772 details
SOCS1_HUMANCUED2_HUMANBioGRID29991678 details
SOCS1_HUMANUFO_HUMANBioGRID, HPRD12470648 29991678 details
SOCS1_HUMANCSF1_HUMANBioGRID, HPRD11297560 29991678 details
SOCS1_HUMANJAK3_HUMANBioGRID, HPRD11133764 27144517 29674694 29991678 details
SOCS1_HUMANTIE2_HUMANBioGRID, HPRD10022833 29991678 details
SOCS1_HUMANERBB4_HUMANBioGRID22973453 details
SOCS1_HUMANYES_HUMANBioGRID31101761 details
SOCS1_HUMANSRC_HUMANBioGRID31101761 details
SOCS1_HUMANLYN_HUMANBioGRID31101761 details
SOCS1_HUMANBLK_HUMANBioGRID31101761 details
SOCS1_HUMANPGFRB_HUMANHPRD10022833 details
SOCS1_HUMANTBA3C_HUMANMINT19327355 details
SOCS1_HUMANTBA3D_HUMANMINT19327355 details
SOCS1_HUMANELOB_HUMANBioGRID, HPRD, IntAct10051596 21119685 29991678 31980649 details
SOCS1_HUMANIRS2_HUMANBioGRID, HPRD12228220 27507812 29991678 details
SOCS1_HUMANIRS1_HUMANBioGRID, HPRD11208867 12228220 17276034 29991678 details
SOCS1_HUMANFLT3_HUMANBioGRID, HPRD10022833 29991678 details
SOCS1_HUMANVAV2_HUMANBioGRID, HPRD10022833 29991678 details
SOCS1_HUMANTPOR_HUMANBioGRID, HPRD10517496 29991678 details
SOCS1_HUMANELOA1_HUMANBioGRID10051596 29991678 details
SOCS1_HUMANSOCS2_HUMANBioGRID17898043 29991678 details
SOCS1_HUMANALK_HUMANBioGRID14968112 details
SOCS1_HUMANIRF3_HUMANBioGRID21079688 29991678 details
SOCS1_HUMANPTN11_HUMANBioGRID14522994 29991678 details
SOCS1_HUMANCLC7A_HUMANBioGRID21899704 29991678 details
SOCS1_HUMANTBG1_HUMANBioGRID15456882 29991678 details
SOCS1_HUMANVHL_HUMANBioGRID21685897 29991678 details
SOCS1_HUMANTIRAP_HUMANBioGRID, HPRD16415872 29991678 details
SOCS1_HUMANDAB1_HUMANBioGRID17974915 29991678 details
SOCS1_HUMANETV6_HUMANBioGRID11314018 29991678 details
SOCS1_HUMANRASA1_HUMANBioGRID18556463 29991678 details
SOCS1_HUMANPDCD1_HUMANBioGRID21263070 29991678 details
SOCS1_HUMANFGFR3_HUMANBioGRID16410555 29991678 details
SOCS1_HUMANATR_HUMANBioGRID20005840 29991678 details
SOCS1_HUMANABL1_HUMANBioGRID22787435 29991678 details
SOCS1_HUMANIL3RB_HUMANBioGRID24086733 29991678 details
SOCS1_HUMANTRAF6_HUMANBioGRID26633718 29991678 details
SOCS1_HUMANNECT1_HUMANBioGRID28258213 details
SOCS1_HUMANJOS1_HUMANBioGRID28355105 details
SOCS1_HUMANIL7RA_HUMANBioGRID27423467 details
SOCS1_HUMANCXCR4_HUMANBioGRID, HPRD12163560 29991678 details
SOCS1_HUMANINGR1_HUMANBioGRID, HPRD15522878 29991678 details
SOCS1_HUMANP85B_HUMANBioGRID, HPRD10022833 29991678 details
SOCS1_HUMANPIM2_HUMANBioGRID, HPRD11854514 29991678 details
SOCS1_HUMANTRIM8_HUMANBioGRID, HPRD12163497 29991678 details
SOCS1_HUMANTRI14_HUMANBioGRID31668806 details
SOCS1_HUMANSOCS1_HUMANBioGRID31101761 31980649 details
SOCS1_HUMANUBP7_HUMANBioGRID31691271 details
SOCS1_HUMANP73_HUMANBioGRID31101761 details