Entity Details

Primary name CHD8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9HCK8
EntryNameCHD8_HUMAN
FullNameChromodomain-helicase-DNA-binding protein 8
TaxID9606
Evidenceevidence at protein level
Length2581
SequenceStatuscomplete
DateCreated2002-09-19
DateModified2021-06-02

Ontological Relatives

GenesCHD8

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001701 in utero embryonic development
GO:0002039 p53 binding
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003682 chromatin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0007420 brain development
GO:0008013 beta-catenin binding
GO:0008094 ATPase, acting on DNA
GO:0016055 Wnt signaling pathway
GO:0032991 protein-containing complex
GO:0035064 methylated histone binding
GO:0035176 social behavior
GO:0042393 histone binding
GO:0043044 ATP-dependent chromatin remodeling
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045945 positive regulation of transcription by RNA polymerase III
GO:0048565 digestive tract development
GO:0060134 prepulse inhibition
GO:0070016 armadillo repeat domain binding
GO:0070615 nucleosome-dependent ATPase activity
GO:0071339 MLL1 complex
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:2000270 negative regulation of fibroblast apoptotic process

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000330 SNF2, N-terminalDomainDomain
IPR000953 Chromo/chromo shadow domainDomainDomain
IPR001650 Helicase, C-terminalDomainDomain
IPR006576 BRK domainDomainDomain
IPR014001 Helicase superfamily 1/2, ATP-binding domainDomainDomain
IPR016197 Chromo-like domain superfamilyFamilyHomologous superfamily
IPR023780 Chromo domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR034724 Chromodomain-helicase-DNA-binding protein 8FamilyFamily
IPR037259 BRK domain superfamilyFamilyHomologous superfamily
IPR038718 SNF2-like, N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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