Entity Details

Primary name TOPRS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NS56
EntryNameTOPRS_HUMAN
FullNameE3 ubiquitin-protein ligase Topors
TaxID9606
Evidenceevidence at protein level
Length1045
SequenceStatuscomplete
DateCreated2006-04-18
DateModified2021-06-02

Ontological Relatives

GenesTOPORS

GO terms

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GOName
GO:0000151 ubiquitin ligase complex
GO:0000209 protein polyubiquitination
GO:0000922 spindle pole
GO:0000930 gamma-tubulin complex
GO:0003677 DNA binding
GO:0003823 antigen binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005814 centriole
GO:0006351 transcription, DNA-templated
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006513 protein monoubiquitination
GO:0006974 cellular response to DNA damage stimulus
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010842 retina layer formation
GO:0016605 PML body
GO:0016607 nuclear speck
GO:0016925 protein sumoylation
GO:0019789 SUMO transferase activity
GO:0030496 midbody
GO:0032391 photoreceptor connecting cilium
GO:0034504 protein localization to nucleus
GO:0035845 photoreceptor cell outer segment organization
GO:0036064 ciliary basal body
GO:0042127 regulation of cell population proliferation
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043066 negative regulation of apoptotic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044547 DNA topoisomerase binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046548 retinal rod cell development
GO:0046549 retinal cone cell development
GO:0046872 metal ion binding
GO:0051443 positive regulation of ubiquitin-protein transferase activity
GO:0051457 maintenance of protein location in nucleus
GO:0061630 ubiquitin protein ligase activity
GO:0070936 protein K48-linked ubiquitination

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001841 Zinc finger, RING-typeDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site

Diseases

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Interactions

54 interactions

InteractorPartnerSourcesPublicationsLink
TOPRS_HUMANSNIP1_HUMANHPRD, MINT15231748 details
TOPRS_HUMANP53_HUMANBioGRID, HPRD, MINT10415337 11842245 15247280 16122737 17290218 17803295 details
TOPRS_HUMANCASP8_HUMANBioGRID, HPRD, MINT17290218 details
TOPRS_HUMANUB2D1_HUMANBioGRID, IntAct15247280 18077445 19053840 19690564 details
TOPRS_HUMANUB2D2_HUMANBioGRID, IntAct19690564 details
TOPRS_HUMANUB2D3_HUMANBioGRID, IntAct15247280 19690564 details
TOPRS_HUMANUB2D4_HUMANBioGRID, IntAct19690564 details
TOPRS_HUMANUB2J1_HUMANBioGRID, IntAct19690564 details
TOPRS_HUMANUB2L6_HUMANBioGRID, IntAct19690564 details
TOPRS_HUMANUBE2N_HUMANBioGRID, IntAct19690564 details
TOPRS_HUMANUBE2W_HUMANBioGRID, IntAct19690564 details
TOPRS_HUMANSATB1_HUMANBioGRID, IntAct18408014 20351170 details
TOPRS_HUMANSETX_HUMANUniProt24244371 details
TOPRS_HUMANUBC9_HUMANBioGRID, HPRD14516784 16122737 details
TOPRS_HUMANSUMO1_HUMANBioGRID, HPRD11842245 14516784 16524884 details
TOPRS_HUMANTOP1_HUMANBioGRID, HPRD10352183 17976381 20805487 details
TOPRS_HUMANHABP4_HUMANBioGRID, HPRD16455055 details
TOPRS_HUMANSIN3A_HUMANBioGRID17803295 details
TOPRS_HUMANPLK1_HUMANBioGRID19473992 19821153 22972498 details
TOPRS_HUMANNKX31_HUMANBioGRID18077445 details
TOPRS_HUMANPAIRB_HUMANBioGRID, HPRD16679534 details
TOPRS_HUMANH2AX_HUMANBioGRID22972498 details
TOPRS_HUMANUB2E1_HUMANBioGRID15247280 details
TOPRS_HUMANSUMO2_HUMANBioGRID16524884 details
TOPRS_HUMANLYRIC_HUMANBioGRID24529480 details
TOPRS_HUMANUBC_HUMANBioGRID15247280 details
TOPRS_HUMANEPM2A_HUMANBioGRID26493215 details
TOPRS_HUMANPRS4_HUMANBioGRID26872363 details
TOPRS_HUMANSPOP_HUMANBioGRID29996942 details
TOPRS_HUMANXRCC1_HUMANBioGRID29668892 details
TOPRS_HUMANCBP_HUMANBioGRID28680062 details
TOPRS_HUMANTOPRS_HUMANHPRD11842245 details
TOPRS_HUMANAPOE_HUMANIntAct31413325 details
TOPRS_HUMANGTF2I_HUMANBioGRID17803295 details
TOPRS_HUMANNONO_HUMANBioGRID17803295 details
TOPRS_HUMANSFPQ_HUMANBioGRID17803295 details
TOPRS_HUMANPARP1_HUMANBioGRID17803295 details
TOPRS_HUMANSAFB2_HUMANBioGRID17803295 details
TOPRS_HUMANDDB2_HUMANBioGRID17803295 details
TOPRS_HUMANRBBP7_HUMANBioGRID17803295 details
TOPRS_HUMANTIF1B_HUMANBioGRID17803295 details
TOPRS_HUMANRBBP4_HUMANBioGRID17803295 details
TOPRS_HUMANSMRC2_HUMANBioGRID17803295 details
TOPRS_HUMANDHX15_HUMANBioGRID17803295 details
TOPRS_HUMANHNRPL_HUMANBioGRID17803295 details
TOPRS_HUMANRAGP1_HUMANBioGRID17803295 details
TOPRS_HUMANREN3A_HUMANBioGRID17803295 details
TOPRS_HUMANHNRPM_HUMANBioGRID17803295 details
TOPRS_HUMANROA1_HUMANBioGRID17803295 details
TOPRS_HUMANSF3B1_HUMANBioGRID17803295 details
TOPRS_HUMANEF1A1_HUMANBioGRID17803295 details
TOPRS_HUMANS10A9_HUMANBioGRID17803295 details
TOPRS_HUMANIKKE_HUMANBioGRID20188669 details
TOPRS_HUMANPML_HUMANBioGRID20188669 details