Entity Details

Primary name IRAK4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NWZ3
EntryNameIRAK4_HUMAN
FullNameInterleukin-1 receptor-associated kinase 4
TaxID9606
Evidenceevidence at protein level
Length460
SequenceStatuscomplete
DateCreated2004-07-19
DateModified2021-06-02

Ontological Relatives

GenesIRAK4

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0002224 toll-like receptor signaling pathway
GO:0002446 neutrophil mediated immunity
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0004674 protein serine/threonine kinase activity
GO:0005149 interleukin-1 receptor binding
GO:0005524 ATP binding
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007254 JNK cascade
GO:0010008 endosome membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0035556 intracellular signal transduction
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0070498 interleukin-1-mediated signaling pathway
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1990266 neutrophil migration

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR017428 Interleukin-1 receptor-associated kinase 4FamilyFamily
IPR037970 IRAK4, Death domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB08590 1-(3-HYDROXYPROPYL)-2-[(3-NITROBENZOYL)AMINO]-1H-BENZIMIDAZOL-5-YL PIVALATEDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

30 interactions

InteractorPartnerSourcesPublicationsLink
IRAK4_HUMANPELI1_HUMANBioGRID, DIP, HPRD, IntAct12496252 16951688 17675297 17997719 19264966 21204785 32296183 details
IRAK4_HUMANMYD88_HUMANBioGRID, DIP, HPRD, IntAct11960013 12538665 12860405 17548806 18221795 20485341 22011580 24316379 24735611 25416956 25502805 25910212 26871637 31515488 32296183 details
IRAK4_HUMANPELI2_HUMANBioGRID, HPRD, IntAct12860405 17675297 details
IRAK4_HUMANIRAK1_HUMANBioGRID, HPRD, IntAct11960013 12538665 12860405 16024789 16951688 17276401 17785851 18221795 19166926 21903422 24735611 details
IRAK4_HUMANTBPL1_HUMANHPRD, IntAct16169070 details
IRAK4_HUMANARNT_HUMANBioGRID, IntAct21988832 details
IRAK4_HUMANTIRAP_HUMANBioGRID, IntAct18221795 21903422 details
IRAK4_HUMANTRIM7_HUMANBioGRID, IntAct32296183 details
IRAK4_HUMANI36RA_HUMANBioGRID, IntAct32296183 details
IRAK4_HUMANZN597_HUMANBioGRID, IntAct32296183 details
IRAK4_HUMANIRAK4_HUMANDIP24316379 details
IRAK4_HUMANH11_HUMANBioGRID15927069 details
IRAK4_HUMANH15_HUMANBioGRID15927069 details
IRAK4_HUMANH12_HUMANBioGRID15927069 details
IRAK4_HUMANH13_HUMANBioGRID15927069 details
IRAK4_HUMANH14_HUMANBioGRID15927069 details
IRAK4_HUMANH1T_HUMANBioGRID15927069 details
IRAK4_HUMAN4EBP1_HUMANBioGRID15927069 details
IRAK4_HUMANMBP_HUMANBioGRID15927069 details
IRAK4_HUMANNEMO_HUMANBioGRID23986494 details
IRAK4_HUMANILRL1_HUMANBioGRID, UniProt16286016 details
IRAK4_HUMANTR13B_HUMANBioGRID, InnateDB20676093 details
IRAK4_HUMANIRAK2_HUMANBioGRID, DIP, IntAct20485341 21903422 details
IRAK4_HUMANTLR4_HUMANBioGRID, IntAct21220427 21829704 details
IRAK4_HUMANTRAF6_HUMANBioGRID, HPRD11960013 23381138 details
IRAK4_HUMANPELI3_HUMANBioGRID, HPRD17675297 details
IRAK4_HUMANIL1R1_HUMANBioGRID12609980 details
IRAK4_HUMANSASH1_HUMANBioGRID23776175 details
IRAK4_HUMANRN152_HUMANBioGRID31930677 details
IRAK4_HUMANTCAM2_HUMANHPRD12721283 details