Entity Details

Primary name PD1L1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NZQ7
EntryNamePD1L1_HUMAN
FullNameProgrammed cell death 1 ligand 1
TaxID9606
Evidenceevidence at protein level
Length290
SequenceStatuscomplete
DateCreated2005-05-10
DateModified2021-06-02

Ontological Relatives

GenesCD274

GO terms

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GOName
GO:0002250 adaptive immune response
GO:0002845 positive regulation of tolerance induction to tumor cell
GO:0005654 nucleoplasm
GO:0005886 plasma membrane
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0009897 external side of plasma membrane
GO:0015629 actin cytoskeleton
GO:0016021 integral component of membrane
GO:0030335 positive regulation of cell migration
GO:0031295 T cell costimulation
GO:0031901 early endosome membrane
GO:0032689 negative regulation of interferon-gamma production
GO:0032693 negative regulation of interleukin-10 production
GO:0032733 positive regulation of interleukin-10 production
GO:0034097 response to cytokine
GO:0042102 positive regulation of T cell proliferation
GO:0042130 negative regulation of T cell proliferation
GO:0046007 negative regulation of activated T cell proliferation
GO:0055038 recycling endosome membrane
GO:0070062 extracellular exosome
GO:0071222 cellular response to lipopolysaccharide
GO:1901998 toxin transport
GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production
GO:1905404 positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process
GO:2000562 negative regulation of CD4-positive, alpha-beta T cell proliferation
GO:2001186 negative regulation of CD8-positive, alpha-beta T cell activation

Subcellular Location

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Subcellular Location
Cell membrane
Early endosome membrane
Endomembrane system
Recycling endosome membrane

Domains

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DomainNameCategoryType
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013106 Immunoglobulin V-set domainDomainDomain
IPR013162 CD80-like, immunoglobulin C2-setDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB11595 AtezolizumabDrugbankbiotech
DB11714 DurvalumabDrugbankbiotech
DB11945 AvelumabDrugbankbiotech
DB15769 EnvafolimabDrugbankbiotech
DB15770 CosibelimabDrugbankbiotech
DB15771 AUNP-12Drugbankbiotech
DB15772 CA-170Drugbanksmall molecule
DB15773 anti-OX40 antibody BMS 986178Drugbankbiotech